graduate at Ciências Biológicas from Universidade de São Paulo (1995), master's at Immunology from Universidade de São Paulo (2000) and ph.d. at Immunology from Universidade de São Paulo (2005). Has experience in Immunology, focusing on Immunology, acting on the following subjects: asthma, immune tolerance, nkt, eosinophils, neutrophils, kidney and lung inflammatory diseases. (Source: Lattes Curriculum)
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The liver is responsible for several vital functions, and due to its physiological and anatomical characteristics, it is a constant target of different injuries. In this context, the magnitude and duration of the inflammatory process associated with tissue damage directly impact liver physiology. Given the direct relationship between inflammation and the activation of the immune system, i…
The gut lumen contains several microbial agents that are essential for digestion and so for nutrient supply. The local immune compartment is critical for shaping the gut microbiota and maintaining the intestinal barrier. The iNKTs influence both the microbiota profile and intestinal inflammation, whereas the IL-22-producing ILC3 cells are essential to control bacterial translocation from …
Although a growing body of evidence supports the notion that the sympathetic nervous system (SNS) influences the immune system (IS), the relationship between the SNS and the invariant Natural Killer T lymphocytes remains underestimated. These cells are part of a lymphocyte population with selectivity for lipid antigens that are recognized by their potent immunoregulatory properties. Upon …
Although immunotherapy is an alternative to a large number of diseases mediated by the immune system, the use of specific agonists to the invariant Natural Killer T (iNKT) lymphocytes remains neglected.One of these antagonists, the alfa-Galactosylceramide (a-GalCer), has been used in clinical trials, however, despite positive results, its efficiency is underwhelming. This contradiction ma…
(Only some records are available in English at this moment)
Liver homeostasis, due to its anatomical structure, depends on the tolerance to microbiota derivatives and immunity to pathogens. In this sense, several studies highlighted the role of invariant T Natural Killer (iNKT) cells in the physiopathology of immune-mediated hepatic diseases. These cells constitute a group of non-conventional T lymphocytes with selectivity for glycolipids expresse…
Invariant Natura Killer T lymphocytes (iNKT) are immune cells that recognize lipid antigens compexed into CD1D molecules. Alpha-GalactosylCeramide (a-GalCer) is the most studied agonist, with main feature being the capacity to rapidly induce secretion of several cytokines. This ability to potentiate immune responses has been demonstrated in different clinical and experimental studies. Alt…
Despite the efforts of many research groups, one issue that still intrigues the scientific community are the mechanisms that control the evolution of neoplastic cells. This is drawing attention to the role of immune cells in the tumor microenvironment, especially innate immunity cells. Among them, macrophages play a controversial role. Some studies show that infiltrating macrophages can c…
Paracocciodioidomicosis (PCM), caused by the fungus Paracoccidioides brasiliensis (Pb), it is one of the most prevalent systemic human mycosis in Latin America. Both human and murine models, the resistance to PCM is been associated with a Type I immunological response with high levels o IFN-³ and TNF-±, which would be associated with organized granuloma formation and fungal contention.Onc…
(Only some records are available in English at this moment)
The focal and segmental glomerulosclerosis (FSGS) is a leading cause of chronic kidney disease and is associated with an increasing number of dialysis and transplantation. The allergic asthma is a chronic disease that is increasing worldwide in the last decades. Because of the high levels of mortality and morbidity both diseases are considered as a socioeconomic problem. This situation is…
| 1 / 1 | Ongoing research grants |
| 5 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 10 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 19 / 15 | All research grants and scholarships |
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CV Lattes
ORCID