graduate at Engenharia Química from Universidade Estadual de Campinas (1994), master's at Chemical Engineering from Universidade Estadual de Campinas (1998) and ph.d. at Chemical Engineering from Universidade Estadual de Campinas (2002). Has experience in Chemical Engineering, acting on the following subjects: aprotinina, cristalização de proteínas, agentes tuberculostáticos, lipossomas and encapsulação de fármacos. (Source: Lattes Curriculum)
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A major limitation on the development of gene therapy and DNA vaccination protocols is the lack of efficient and safe gene delivery vectors. Although safer, non-viral gene delivery vectors must overcome a series of physical, enzymatic and diffusional barriers in order to reach the target cells nuclei. Following the strategy studied by our group, the objective of this project is the delop…
The low efficiency during the delivery of nucleic acids to tumor cells is a recurring problem in gene therapy studies for the treatment of cancer. This problem is mainly caused by the difficulty in directing and transporting the therapeutic molecules to the target cells due to the presence of numerous physical, enzymatic and diffusional barriers. Over the past few years, our research grou…
The use of non-viral vectors like plasmid DNA (pDNA) in gene therapy and DNA vaccination studies has been limited by their low efficiency compared to viral vectors. This is mainly due to the limited capacity to overcome physical, enzymatic and diffusional barriers in the transport to the nuclei of target cells. Besides that limitation, the lack of systematic studies of the influence of no…
Conversion of lignocellulosic biomass into fermentable sugars by enzymatic hydrolysis still represents a high cost step for production of second generation ethanol. To overcome this drawback, it is important to increase the enzyme efficiency and decrease production costs by using genetic engineering tools and process optimization. Hence, the development of more efficient heterologous expr…
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The definition of an ideal gene delivery vector has recently been modified to include cell targeting as a major issue. Our group has developed a recombinant dynein-based vector, T-Rp3, which proved to be very efficient for cell uptake and intracellular trafficking, but its in vivo application may be severely limited by its lack of cell specificity. In this context, our recent collaboratio…
This research project is part of a doctorship project that aims the model development to calculating the potential of mean force among protein molecules into solution with dissolved salts in order to achieve a better understanding of the protein-protein interactions and to describe its phase diagram with high accuracy. Specifically in the abroad internship, the efforts will be concentrate…
| 2 / 1 | Completed research grants |
| 14 / 7 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 19 / 10 | All research grants and scholarships |
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