graduate at Farmácia e Bioquímica from Universidade de São Paulo (1989) and ph.d. at Biochemistry from Universidade de São Paulo (1995). Has experience in Biochemistry, focusing on Biochemistry, acting on the following subjects: trypanosoma, phage display, doença de chagas, tc-85 and adesão. (Source: Lattes Curriculum)
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Blood vessels play a central role in the most diverse physiological and pathological processes. Over the past few years, our group has been studying two important aspects of vascular biology: the process of formation of new blood vessels by angiogenesis and the molecular heterogeneity of vascular networks in different organs and tissues of the body. Understanding the molecular mechanisms …
The concept of vascular heterogeneity is well accepted by the scientific community, playing an essential role in physiological and pathological processes. Since blood vessels are important in organogenesis, differentiation, and morphogenesis of tissues and organs, it becomes interesting to unveil the cerebral vascular diversity, identifying new molecular markers for such important organ. …
Angiogenesis, the formation of new blood vessels from pre-existing ones, is an important process in vertebrate organisms, in physiological and pathological conditions. Retinopathy, a primary reason for legal blindness in adults, is an example in which angiogenesis has a key role in disease formation and progression. Macular degeneration and diabetic and retinopathy of prematurity are dis…
Angiogenesis is the formation of new blood vessels from pre-existing ones and it is an important process in health and disease. Examples in which angiogenesis participate in disease are cancer and retinopathy, a important cause for blindness in adults. Retinopathy of prematurity or in diabetes, as well as macula degeneration have an important angiogenic component. These diseases afflict p…
(Only some records are available in English at this moment)
Validate miRNA with altered expression in retinopathy. The candidate will initially work on the experimental validation of the built model. For example, confirm the differential expression of regulatory RNA (miRNA, circRNA), proteins, and signaling pathways used preferentially in pathological processes. It will also validate the expression of new miRNA in the retina. The identification of…
The vascular endothelial growth factor (VEGF) and its receptors are the major modulators to form a new vascular network from pre-existing blood vessels, a process known as angiogenesis. Anti-VEGF therapies are a reality and an option for the treatment of angiogenesis-dependent diseases, such as cancer and some retinopathies. These therapies have as target the inhibition of VEGF or of the …
Angiogenesis is the process by which new blood vessels are formed from pre-existing blood vessels. In adults, angiogenesis is restricted to specific circumstances, such as wound healing and female cycle. However, this process plays a key role in pathological conditions such as Cancer and Retinopathy. Using an animal model of oxygen induced retinopathy and RNAseq, we identified several gen…
(Only some records are available in English at this moment)
Chagas' disease, caused by the parasite Trypanosoma cruzi, affects 7 to 8 million people worldwide. The condition can be debilitating, and even life-threatening, to those that develop cardiomyopathy or one of the digestive forms of the disease, making it a significant burden to health care and society at large. Treatment options for patients are still limited to two drugs, both of them wi…
Angiogenesis is the process of blood vessels formation from preexisting vessels. Angiogenesis is important for physiological and pathological processes, such as cancer and retinopathy. Current anti-angiogenic therapies affect the homeostasis of normal blood vessels. Therefore, it is important to better understand the molecular mechanisms of angiogenesis as such knowledge might help the d…
| 1 / 1 | Ongoing research grants |
| 5 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 17 / 15 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 28 / 24 | All research grants and scholarships |
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CV Lattes
ORCID