CV Lattes
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Universidade Estadual Paulista (UNESP). Campus Experimental do Litoral Paulista. Instituto de Biociências (IB-CLP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade Federal de São Carlos (1994), master's at Genetics from Universidade Federal de São Carlos (1997) and ph.d. at Genetics from Universidade Estadual de Campinas (2003). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: cristalização de proteínas, metabolismo e bioenergética, estrutura de proteínas, biotecnologia and radicais livres. (Source: Lattes Curriculum)
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Typical 2-Cys peroxiredoxins (2-Cys Prx) represent a group of antioxidant proteins able to decompose several types of hydroperoxides at rates of 105-8M-1s-1. These enzymes utilize a cysteine residue (peroxidatic cysteine - CP) which, after the peroxide decomposition, oxidizes (CP-SOH) forming a disulfide bond with a second cysteine which is reduced by the enzymes thioredoxin (Trx) and thi…
The Plan of Use of Institutional Technical Reserve (RTI) of the Institute of Biosciences of Campus do Litoral Paulista (IB-CLP), consists of a reformulated proposal for the use of resources that contemplates all the observations and considerations raised by the assessor. After extensive discussion, the Congregation decided that RTI, with a value of R $ 40,237.62, will be used to attend t…
There is a strong global tendency to find alternative ways to produce pharmaceutical active principles from biotechnology process. In this scenario, Brazil shows a small expression in both research and production. Worsening the situation, international suppliers of biopharmaceuticals to Brazil are losing interest in the market and discontinuing production, especially those related to onco…
Recent studies indicate that the resistance of bacteria to antibacterials may be directly related to oxidative stress, since antibacterials of different classes have the common ability to generate reactive oxygen species (ROSs), which cause damage to macromolecules, especially DNA, accentuating the mutation rates which can contribute to the appearance of super-resistant strains. ROSs are …
Reactive oxygen (ROS) and nitrogen species (RNS) are produced by the defense repertoire of the hosts' immune system to combat microbial pathogens and by the antibiotics administration. Among ROS, organic hydroperoxides (OHPs), including lipid hydroperoxides, are potent microbicidal agents. 2-Cys peroxiredoxins (2-Cys Prx) represent an important line of defense capable to decompose a high …
The massive production of reactive oxygen and nitrogen species (ROS and RNS) represents one of the main lines of defense of hosts against the attack of pathogenic microorganisms. However, in the course of evolution, microorganisms have developed highly efficient enzymes capable of decomposing ROS and RNS and neutralizing host defenses, such as peroxiredoxins (Prx), which are distinguished…
The increasing incidence of infections resistant to the action of different classes of antibiotics together with the decline of the discovery of new efficient classes in the fight against pathogens poses a threat to global public health. In this context, there is a need to expand the understanding of microbial defense mechanisms in order to potentiate the inactivation and death of pathoge…
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Bacterial asparaginases (ASNase) are high molecular weight tetrameric enzymes (~140kDa) used as therapeutic proteins for treatment of acute lymphoblastic leukemia (ALL), since some tumor cell types are dependent on the availability of extracellular L-asparagine. Bacterial ASNase efficiently hydrolyzes aparagine (L-Asn) into aspartic acid (L-Asp) and ammonia, decreasing the source of L-Asn…
| 5 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 28 / 23 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 35 / 28 | All research grants and scholarships |
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