CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Assis. Faculdade de Ciências e Letras (FCL-ASSIS) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Medicina Veterinária from Universidade Estadual Paulista Júlio de Mesquita Filho (1988), master's at Veterinary Medicine from Universidade Estadual Paulista Júlio de Mesquita Filho (2001) and ph.d. at Veterinary Medicine from Universidade Estadual Paulista Júlio de Mesquita Filho (2005). Has experience in Veterinary Medicine, acting on the following subjects: superovulação, transferência de embrião, bos indicus, lh and taxa de gestação. (Source: Lattes Curriculum)
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In vitro maturation (IVM) restricts the use of hormones in vivo preventing excessive spending and handling of the animal, and the harmful iatrogenic effects of ovarian overstimulation. However, the IVM systems are not comparably efficient to physiological events that occur in vivo, mainly concerning the synchronization between the nuclear and cytoplasmic maturation of the oocyte. Removed …
Reproductive technologies are important tools in cattle breeding with Artificial Insemination (AI) used for more than 50 years and Embryo Transfer (ET) used since the mid-1980s. More recently, ET of in vitro produced (IVP) embryos derived from ultrasound-guided collection of oocytes (Ovum Pick-Up, OPU) from superior donor cows has been introduced. This technique is used increasingly world…
(Only some records are available in English at this moment)
Colorectal cancer is currently the third with the highest incidence and the second in the ranking of deaths in the world. Traditional treatments such as chemotherapy and radiotherapy cause severe side effects, demanding new therapeutic strategies. In this context, photodynamic therapy (PDT) stands out owing to its effectiveness in reducing tumor cell viability. Herein, we shall evaluate t…
In the last decade, there were several technical advances on the in vitro production of bovine embryos. However, the cryopreservation of those embryos is not consistent with the general improvements of the technique. One of the main factors related to the low post-cryopreservation survival rate is their distinct lipid profile and content. The lipids are present as droplets in the cytoplas…
The bovine embryonic development, both in vivo derived and in vitro produced, involves basic aspects of cell differentiation. Throughout embryonic development, the cells that compose the inner cell mass (ICM) differentiate into two new cell lineages: epiblast (origin of germ-layers) and hypoblast (origin of extraembryonic tissues). The fibroblast growth factor (FGF) acts in differentiatio…
Assisted reproduction technologies are increasingly being used, however, although continuously improved, pregnancy is not guaranteed. The embryonic culture and in an uninterrupted way until the blastocyst stage, through the use of the time-lapse system, allowed improvements in the embryonic selection. Thus, from the video originating from monitoring via time-lapse, it is possible to obtai…
In bovine herds the early embryonic mortality, caused by failures in maternal fetal recognition between days 15 and 19 after fertilization, is one of the major causes of reproductive failures. Strategies that may favor maternal fetal recognition during such a critical period become of fundamental economic interest. Such strategies aim to reduce the ability of PGF2 alpha synthesis by the m…
(Only some records are available in English at this moment)
Cancer is currently one of the top diseases in the ranking of deaths in the world. Traditional treatments such as chemotherapy and radiotherapy cause severe side effects, demanding new therapeutic strategies. In this context, photodynamic therapy (PDT) is a non-invasive technique that stands out owing to its effectiveness in reducing tumor cell viability. Herein, we shall evaluate the pho…
Early embryonic mortality, caused by failures in maternal-fetal recognition in the first three weeks after fertilization represents a major cause of reproductive inefficiency in the cattle industry. During this pre-implantation period, the conceptus (embryo and its associated extra-embryonic membranes) present in the uterine lumen must secrete molecules, such as interferon-tau (IFNT), tha…
After the emergence of induced cell reprogramming, performed through the addition of "Yamanaka" transcription factors (Oct4, Sox2, Klf4 and cMyc) to somatic cells, the amount of researches regarding the generation and maintenance of pluripotency has increased greatly. Still, further investigations on the pluripotent state of these cells are still demanding, since different protocols, char…
In vitro maturation (IVM) does not use superstimulatory hormones in vivo, thereby preventing, overspending and animal handling, in addition to the harmful iatrogenic effects of ovarian overstimulation. However, the efficiency of IVM systems do not meet full expectations due to the inability to simulate the physiological events that occur in vivo (i.e. synchronization between nuclear and c…
The SPOM system (simulated physiological oocyte maturation) consists of a prolonged period of maturation while the delayed nuclear maturation by addition of agents which maintains cAMP at high concentrations in the oocyte. The success of SPOM in mouse embryos and cattle in vitro production led to more detailed research on the cellular and molecular mechanisms of this system which constitu…
| 1 / 1 | Ongoing research grants |
| 7 / 5 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 30 / 19 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 45 / 32 | All research grants and scholarships |
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