CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Undergraduate degree in Biological Sciences at Escola Paulista de Medicina (1990), MSc (1993) and PhD (1997) in Microbiology and Immunology at Escola Paulista de Medicina. At the present time, is Associate professor at Pharmacology Department, Universidade Federal de São Paulo. Has experience in Cellular and Molecular Biology of Cancer, and a special interest in the relation among oxidative stress, epigenetic alterations and malignant transformation and melanoma progression. (Source: Lattes Curriculum)
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This proposal aims to strength our hypothesis that epi-drugs, such as demethylating agents, can be an effective treatment for eliminating residual tumor cells by treating both resistant and/or dormant tumor cells (seed) and the microenvironment (soil). The proposal is based on two immunocompetent models: the cellular model of murine melanoma and the model of microenvironment-dependent tum…
Melanomas are tumors that may frequently progress to their most aggressive form, the metastatic one, been responsible for more than 80% of deaths caused by all types of skin cancers. Considering that, if not early diagnosed and treated, it can rapidly progress and become fatal, the search for tumor markers in tumor samples and biological fluids has received increased attention. It is esti…
Malignant melanoma is the most aggressive and treatment resistant human skin cancer, and it is one of the tumor entities with the highest increase in incidence worldwide. The aim of our project is to establish a cooperation between the German (Friedrich-Alexander-Universitat Erlangen-Nurnberg) and the Brazilian (Universidad Federal de São Paulo) research groups, as both have their researc…
(Only some records are available in English at this moment)
Cutaneous melanoma is characterized by the malignant transformation of melanocytes, cells responsible for the production of melanin pigment, which is located close to the basal layer, between the dermis and epidermis. Despite having a low incidence, it is considered the most aggressive skin cancer due to its high metastatic capacity and resistance to therapies. The change in phenotypes (p…
Long non-coding RNAs (lncRNAs) are non-protein-coding RNAs (ncRNAs) and represent the majority of transcripts. It is estimated that 70 to 90% of the human genome is transcribed in ncRNA. Studies have already demonstrated the importance of ncRNAs in modulating gene expression, which is considered an important piece of the epigenetic machinery. LncRNAs participate in the regulation of cell …
Cutaneous melanoma emerges from the malignant transformation of the epidermis melanocytes and is considered the most severe amongst skin tumors due to its high risk of metastasis and therapeutic resistance. Since primary and metastatic melanomas carry, at least in part, the same set of driver mutations, epigenetic reprogramming appears to play an important role in tumor progression and he…
(Only some records are available in English at this moment)
Cutaneous melanoma is a type of skin cancer that has its origin in the malignant transformation of melanocytes and although it has reduced prevalence compared to other types of neoplasms is the most aggressive type among skin tumors. Its aggressiveness is attributed mainly to its resistance to conventional therapies and its high metastatic capacity. One characteristic of this metastatic s…
Cutaneous Melanoma is the most lethal skin cancer among several types of skin cancers. It represents nearly 80 percent of cancer deaths and increasing constantly. Over the last decades, the number of registered cases has doubled (50.000 yearly deaths all over the world). The aggressiveness of the melanoma is due to its metastatic propensity grounded in parts on the aggressive melanoma cel…
Cutaneous melanoma resulting from the malignant transformation of melanocytes is the most aggressive type of skin tumors, the incidence of which is progressively increasing in the world. Recent studies demonstrate changes in epigenetic marks that are involved in the development and progression of this tumor, among these epigenetic modifications are posttranslational modifications (PTMs) i…
(Only some records are available in English at this moment)
Our in vitro melanoma progression model employs substrate adhesion blockade as a malignant transforming factor. The cell lines corresponding to steps of melanoma progression are: melan-a (non-tumorigenic melanocytes), 4C (pre-malignant melanocytes), 4C11- (non-metastatic melanoma cells) and 4C11+ (metastatic melanoma cells). The gene and protein levels of TET2 and 5hmC levels are found to…
MicroRNAs (miRNAs) are one of the most abundant classes of gene regulatory molecules. They are small non-coding RNAs of approximately 22 nucleotides that have important regulatory function in animals and plants by regulating gene expression negatively and post-transcriptionally. In animals, miRNAs binds to mRNAs leading to its destabilization or its translation repression. It is estimated…
Melanoma is an aggressive form of skin cancer that is responsible for the vast majority of skin cancer deaths and its incidence continues to increase worldwide. It is known the existence of many factors that contribute to melanoma development and to increase its incidence, however, there are many questions to be elucidated about the genetics, epigenetics and metabolomics changes that occu…
(Only some records are available in English at this moment)
| 2 / 1 | Ongoing research grants |
| 21 / 12 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 29 / 22 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 62 / 45 | All research grants and scholarships |
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