Graduated in Biological Sciences, medical modality, from Escola Paulista de Medicina (1990) and Master's Degree in Microbiology and Immunology from Escola Paulista de Medicina (1993). Sha developed her PhD at the Instituto Ludwig de Pesquisas sobre o Cancer through the Graduate Program in Microbiology and Immunology at Escola Paulista de Medicina (1997). She held a Post-Doctorate in Cell Biology (1998 to 2000) and Immunology (2002 to 2007) at Escola Paulista de Medicina. She served as Secretary of International Relations at Unifesp from 2014 to 2019. She is currently an associate professor and head of the Department of Pharmacology at Escola Paulista de Medicina, Unifesp. Has experience in the area of Cellular and Molecular Biology of Cancer, with emphasis on the relationship between oxidative stress, epigenetic alterations (DNA methylation, modifications in histones and miRNAs) and melanocyte malignant transformation and melanoma progression. (Source: Lattes Curriculum)
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Tumor cell plasticity contributes to metastatic competence and is related to tumor heterogeneity, reccurence and treatment failure. Melanomas have high propensity to metastasis and frequently become drug resistant. Although patient survival has significantly increased with the more recent therapeutic modalities, as molecular targeted therapies and immunotherapies, majority patients presen…
This proposal aims to strength our hypothesis that epi-drugs, such as demethylating agents, can be an effective treatment for eliminating residual tumor cells by treating both resistant and/or dormant tumor cells (seed) and the microenvironment (soil). The proposal is based on two immunocompetent models: the cellular model of murine melanoma and the model of microenvironment-dependent tum…
Melanomas are tumors that may frequently progress to their most aggressive form, the metastatic one, been responsible for more than 80% of deaths caused by all types of skin cancers. Considering that, if not early diagnosed and treated, it can rapidly progress and become fatal, the search for tumor markers in tumor samples and biological fluids has received increased attention. It is esti…
(Only some records are available in English at this moment)
Melanoma is the most aggressive type of skin cancer due to its ability to generate metastases. It arises from the malignant transformation of melanocytes, the cells responsible for producing melanin, the pigment that gives the skin, eyes, and hair their color. Prolonged exposure to UV light is one of the main factors contributing to the development of melanoma. This aggressiveness and inv…
Cancer is currently considered a highly prevalent malignant disease for being the second leading cause of death in the world, presenting a difficult early diagnosis and because its treatment, when available, is in many cases expensive and inaccessible. Among the cancers that stand out, we can mention prostate cancer, which is one of the most frequent in the male population. Oncogenesis, t…
Cutaneous melanoma is characterized by the malignant transformation of melanocytes, cells responsible for the production of melanin pigment, which is located close to the basal layer, between the dermis and epidermis. Despite having a low incidence, it is considered the most aggressive skin cancer due to its high metastatic capacity and resistance to therapies. The change in phenotypes (p…
Long non-coding RNAs (lncRNAs) are non-protein-coding RNAs (ncRNAs) and represent the majority of transcripts. It is estimated that 70 to 90% of the human genome is transcribed in ncRNA. Studies have already demonstrated the importance of ncRNAs in modulating gene expression, which is considered an important piece of the epigenetic machinery. LncRNAs participate in the regulation of cell …
Cutaneous melanoma emerges from the malignant transformation of the epidermis melanocytes and is considered the most severe amongst skin tumors due to its high risk of metastasis and therapeutic resistance. Since primary and metastatic melanomas carry, at least in part, the same set of driver mutations, epigenetic reprogramming appears to play an important role in tumor progression and he…
(Only some records are available in English at this moment)
Our in vitro melanoma progression model employs substrate adhesion blockade as a malignant transforming factor. The cell lines corresponding to steps of melanoma progression are: melan-a (non-tumorigenic melanocytes), 4C (pre-malignant melanocytes), 4C11- (non-metastatic melanoma cells) and 4C11+ (metastatic melanoma cells). The gene and protein levels of TET2 and 5hmC levels are found to…
MicroRNAs (miRNAs) are one of the most abundant classes of gene regulatory molecules. They are small non-coding RNAs of approximately 22 nucleotides that have important regulatory function in animals and plants by regulating gene expression negatively and post-transcriptionally. In animals, miRNAs binds to mRNAs leading to its destabilization or its translation repression. It is estimated…
Melanoma is an aggressive form of skin cancer that is responsible for the vast majority of skin cancer deaths and its incidence continues to increase worldwide. It is known the existence of many factors that contribute to melanoma development and to increase its incidence, however, there are many questions to be elucidated about the genetics, epigenetics and metabolomics changes that occu…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 23 / 13 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 35 / 28 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 65 / 48 | All research grants and scholarships |
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CV Lattes
ORCID