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Carlos Renato Tirapelli

CV Lattes ORCID


Universidade de São Paulo (USP). Escola de Enfermagem de Ribeirão Preto (EERP)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

bachelor's at from Faculdade de Ciências Farmacêuticas de Ribeirão Preto- USP (1998), master's at Farmacologia from Faculdade de Medicina de Ribeirão Preto (2001) and doctorate at Farmacologia from Faculdade de Medicina de Ribeirão Preto (2005). Has experience in Pharmacology, focusing on Cardiorenal Pharmacology, acting on the following subjects: mechanisms, carotid, aorta, ethanol and inhibitory action. (Source: Lattes Curriculum)

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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (43)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TIRAPELLI, LUIS F.; BATALHAO, MARCELO E.; JACOB-FERREIRA, ANA L.; TIRAPELLI, DANIELA P.; CARNIO, EVELIN C.; TANUS-SANTOS, JOSE E.; QUEIROZ, REGINA H.; UYEMURA, SERGIO A.; PADOVAN, CLAUDIA M.; TIRAPELLI, CARLOS R.. Chronic ethanol consumption induces histopathological changes and increases nitric oxide generation in the rat liver. TISSUE & CELL, v. 43, n. 6, p. 384-391, .

HIPOLITO, ULISSES V.; RODRIGUES, GERSON J.; LUNARDI, CLAURE N.; BONAVENTURA, DANIELLA; AMBROSIO, SERGIO R.; DE OLIVEIRA, ANA M.; BENDHACK, LUSIANE M.; DA COSTA, FERNANDO B.; TIRAPELLI, CARLOS R.. Mechanisms underlying the vasorelaxant action of the pimarane ent-8(14),15-pimaradien-3 beta-ol in the isolated rat aorta. European Journal of Pharmacology, v. 616, n. 1-3, p. 183-191, .

SIMPLICIO, JANAINA A.; RESSTEL, LEONARDO B.; TIRAPELLI, DANIELA P. C.; D'ORLEANS-JUSTE, PEDRO; TIRAPELLI, CARLOS R.. Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment. VASCULAR PHARMACOLOGY, v. 73, p. 124-137, . (10/05815-4, 13/00808-8)

AP SIMPLICIO, JANAINA; PERNOMIAN, LARISSA; SIMAO, MARILIA R.; CARNIO, EVELIN C.; BATALHAO, MARCELO E.; AMBROSIO, SERGIO R.; TIRAPELLI, CARLOS R.. Mechanisms underlying the vascular and hypotensive actions of the labdane ent-3-acetoxy-labda-8(17),13-dien-15-oic acid. European Journal of Pharmacology, v. 726, p. 66-76, . (10/01009-3, 11/13630-7)

GONZAGA, NATALIA ALMEIDA; BATISTELA, MELISSA RESENDE; PADOVAN, DIEGO; DE MARTINIS, BRUNO SPINOSA; TIRAPELLI, CARLOS RENATO; PADOVAN, CLAUDIA MARIA. Ethanol withdrawal induces anxiety-like effects: Role of nitric oxide synthase in the dorsal raphe nucleus of rats. ALCOHOL, v. 52, p. 1-8, . (13/00808-8)

GONZAGA, NATALIA A.; DO VALE, GABRIEL T.; PARENTE, JULIANA M.; YOKOTA, RODRIGO; DE MARTINIS, BRUNO S.; CASARINI, DULCE E.; CASTRO, MICHELE M.; TIRAPELLI, CARLOS R.. Ethanol withdrawal increases blood pressure and vascular oxidative stress: a role for angiotensin type 1 receptors. JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION, v. 12, n. 7, p. 561-573, . (15/22046-8)

LEITE, LETICIA N.; DO VALE, GABRIEL T.; SIMPLICIO, JANAINA A.; DE MARTINIS, BRUNO S.; CARNEIRO, FERNANDO S.; TIRAPELLI, CARLOS R.. Ethanol-induced erectile dysfunction and increased expression of pro-inflammatory proteins in the rat cavernosal smooth muscle are mediated by NADPH oxidase-derived reactive oxygen species. European Journal of Pharmacology, v. 804, p. 82-93, . (13/15824-9)

MARCHI, KATIA COLOMBO; CERON, CARLA SPERONI; MUNIZ, JAQUELINE J.; DE MARTINIS, BRUNO S.; TANUS-SANTOS, JOSE E.; TIRAPELLI, CARLOS RENATO. NADPH Oxidase Plays a Role on Ethanol-Induced Hypertension and Reactive Oxygen Species Generation in the Vasculature. ALCOHOL AND ALCOHOLISM, v. 51, n. 5, p. 522-534, . (12/01147-2, 13/15824-9)

MUNIZ, JAQUELINE J.; LEITE, LETICIA N.; DE MARTINIS, BRUNO S.; CARNEIRO, FERNANDO S.; TIRAPELLI, CARLOS R.. Chronic ethanol consumption induces erectile dysfunction: Role of oxidative stress. Life Sciences, v. 141, p. 44-53, . (11/12911-2, 12/04144-4)

HIPOLITO, ULISSES V.; CALLERA, GLAUCIA E.; SIMPLICIO, JANAINA A.; DE MARTINIS, BRUNO S.; TOUYZ, RHIAN M.; TIRAPELLI, CARLOS R.. Vitamin C prevents the endothelial dysfunction induced by acute ethanol intake. Life Sciences, v. 141, p. 99-107, . (10/05815-4, 10/01383-2)

MUNIZ, JAQUELINE J.; LEITE, LETICIA N.; LACCHINI, RICCARDO; TANUS-SANTOS, JOSE E.; TIRAPELLI, CARLOS R.. Dysregulated mitogen-activated protein kinase and matrix metalloproteinase in ethanol-induced cavernosal dysfunction. Canadian Journal of Physiology and Pharmacology, v. 96, n. 3, . (11/12911-2, 12/04144-4)

CARDA, ANA P. P.; MARCHI, KATIA C.; RIZZI, ELEN; MECAWI, ANDRE S.; ANTUNES-RODRIGUES, JOSE; PADOVAN, CLAUDIA M.; TIRAPELLI, CARLOS R.. Acute restraint stress induces endothelial dysfunction: role of vasoconstrictor prostanoids and oxidative stress. STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, v. 18, n. 2, p. 233-243, . (13/00808-8, 13/04470-1)

CERON, CARLA S.; DO VALE, GABRIEL T.; SIMPLICIO, JANAINA A.; RICCI, STHEFANY T.; DE MARTINIS, BRUNO S.; DE FREITAS, ANDRESSA; TIRAPELLI, CARLOS R.. Chronic ethanol consumption increases vascular oxidative stress and the mortality induced by sub-lethal sepsis: Potential role of iNOS. European Journal of Pharmacology, v. 825, p. 39-47, . (15/22046-8)

SILVA, CARLA B. P.; GOMEZ, JULIETH P. S.; DO VALE, GABRIEL T.; SIMPLICIO, JANAINA A.; GONZAGA, NATALIA A.; TIRAPELLI, CARLOS R.. Interleukin-10 limits the initial steps of the cardiorenal damage induced by ethanol consumption. Life Sciences, v. 242, . (15/22046-8)

SOUSA, ARTHUR H.; DO VALE, GABRIEL T.; NASCIMENTO, JOSE A.; AWATA, WANESSA M. C.; SILVA, CARLA B. P.; ASSIS, VICTOR O.; ALVES, V, JULIANO; TOSTES, RITA C.; TIRAPELLI, CARLOS R.. Inhibition of inducible nitric oxide synthase protects against the deleterious effects of sub-lethal sepsis and ethanol in the cardiorenal system. Canadian Journal of Physiology and Pharmacology, v. 99, n. 12, p. 1324-1332, . (17/24123-5, 18/06583-1, 18/23985-6)

NAKASHIMA, MARCELO A.; SILVA, CARLA B. P.; GONZAGA, NATALIA A.; SIMPLICIO, JANAINA A.; OMOTO, ANA C. M.; TIRAPELLI, LUIS F.; TANUS-SANTOS, JOSE E.; TIRAPELLI, CARLOS R.. Chronic ethanol consumption increases reactive oxygen species generation and the synthesis of pro-inflammatory proteins in the heart through TNFR1-dependent mechanisms. CYTOKINE, v. 121, . (16/11883-9, 14/09595-0)

DO VALE, GABRIEL T.; SOUSA, ARTHUR H.; GONZAGA, NATALIA A.; DE OLIVEIRA, MARIANA G.; JUSTO, ALBERTO F. O.; ALEXANDRE, EDUARDO C.; TANUS-SANTOS, JOSE E.; ANTUNES, EDSON; TIRAPELLI, CARLOS R.. Chronic ethanol consumption induces micturition dysfunction and alters the oxidative state of the urinary bladder. Canadian Journal of Physiology and Pharmacology, v. 97, n. 12, p. 1103-1114, . (17/24123-5)

PEREIRA, BRUNA PINHEIRO; DO VALLE, GABRIEL TAVARES; CORREA SALLES, BRUNO CESAR; MANCINI COSTA, KARLA CRISTINNE; ANGELO, MARILENE LOPES; LOBO TORRES, LARISSA HELENA; NOVAES, ROMULO DIAS; RUGINSK, SILVIA GRACIELA; TIRAPELLI, CARLOS RENATO; DE ARAUJO PAULA, FERNANDA BORGES; et al. Pyrrolidine dithiocarbamate reduces alloxan-induced kidney damage by decreasing nox4, inducible nitric oxide synthase, and metalloproteinase-2. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v. 393, n. 10, . (15/22046-8)

SOUSA, ARTHUR H.; DO VALE, GABRIEL T.; DA SILVA, CARLA B. P.; AWATA, WANESSA M. C.; PINHEIRO, LUCAS C.; TIRAPELLI, CARLOS R.. Ethanol and cyclophosphamide induce similar nephrotoxic effects: possible role for Nox4 and superoxide. Canadian Journal of Physiology and Pharmacology, v. 99, n. 7, p. 744-751, . (17/24123-5)

DO VALE, GABRIEL T.; DA SILVA, CARLA B. P.; SOUSA, ARTHUR H.; GONZAGA, NATALIA A.; PARENTE, JULIANA M.; ARAUJO, KATIUSCIA M.; CASTRO, MICHELE M.; TIRAPELLI, CARLOS R.. Nebivolol Prevents Up-Regulation of Nox2/NADPH Oxidase and Lipoperoxidation in the Early Stages of Ethanol-Induced Cardiac Toxicity. Cardiovascular Toxicology, v. 21, n. 3, p. 224-235, . (13/15824-9)

ASSIS, VICTOR O.; GONZAGA, NATALIA A.; SILVA, CARLA B. P.; PEREIRA, LUCAS C.; PADOVAN, CLAUDIA M.; TIRAPELLI, CARLOS R.. Ethanol Withdrawal Alters the Oxidative State of the Heart Through AT(1)-Dependent Mechanisms. ALCOHOL AND ALCOHOLISM, v. 55, n. 1, p. 3-10, . (15/22046-8, 13/00808-8)

YOGI, ALVARO; CALLERA, GLAUCIA E.; MECAWI, ANDRE S.; BATALHAO, MARCELO E.; CARNIO, EVELIN C.; ANTUNES-RODRIGUES, JOSE; QUEIROZ, REGINA H.; TOUYZ, RHIAN M.; TIRAPELLI, CARLOS R.. Acute ethanol intake induces superoxide anion generation and mitogen-activated protein kinase phosphorylation in rat aorta: A role for angiotensin type 1 receptor. Toxicology and Applied Pharmacology, v. 264, n. 3, p. 470-478, . (10/05815-4)

ROCHA, JULIANA T.; HIPOLITO, ULISSES V.; MARTINS-OLIVEIRA, ALISSON; TIRAPELLI, DANIELA P. C.; BATALHAO, MARCELO E.; CARNIO, EVELIN C.; QUEIROZ, REGINA H.; COELHO, EDUARDO B.; CUNHA, THIAGO M.; TANUS-SANTOS, JOSE E.; et al. Ethanol Consumption Alters the Expression and Reactivity of Adrenomedullin in the Rat Mesenteric Arterial Bed. ALCOHOL AND ALCOHOLISM, v. 47, n. 1, p. 9-17, .

PASSAGLIA, PATRICIA; CERON, CARLA S.; MECAWI, ANDRE S.; ANTUNES-RODRIGUES, JOSE; COELHO, EDUARDO B.; TIRAPELLI, CARLOS R.. Angiotensin type 1 receptor mediates chronic ethanol consumption-induced hypertension and vascular oxidative stress. VASCULAR PHARMACOLOGY, v. 74, p. 49-59, . (10/05815-4, 12/10096-2)

PASSAGLIA, PATRICIA; GONZAGA, NATALIA A.; TIRAPELLI, DANIELA P. C.; TIRAPELLI, LUIS F.; TIRAPELLI, CARLOS R.. Pharmacological characterisation of the mechanisms underlying the relaxant effect of adrenomedullin in the rat carotid artery. Journal of Pharmacy and Pharmacology, v. 66, n. 12, p. 1734-1746, . (11/12911-2)

TIRAPELLI, LUIS F.; MARTINS-OLIVEIRA, ALISSON; BATALHAO, MARCELO E.; TIRAPELLI, DANIELA P.; CARNIO, EVELIN C.; TANUS-SANTOS, JOSE E.; QUEIROZ, REGINA H.; PADOVAN, CLAUDIA M.; TIRAPELLI, CARLOS R.. Ethanol consumption increases the expression of endothelial nitric oxide synthase, inducible nitric oxide synthase and metalloproteinases in the rat kidney. Journal of Pharmacy and Pharmacology, v. 64, n. 1, p. 68-76, .

HIPOLITO, ULISSES V.; ROCHA, JULIANA T.; MARTINS-OLIVEIRA, ALISSON; TIRAPELLI, DANIELA P. C.; JACOB-FERREIRA, ANA; BATALHAO, MARCELO E.; TANUS-SANTOS, JOSE E.; CARNIO, EVELIN C.; CUNHA, THIAGO M.; QUEIROZ, REGINA H.; et al. Chronic ethanol consumption reduces adrenomedullin-induced relaxation in the isolated rat aorta. ALCOHOL, v. 45, n. 8, p. 805-814, .

GONZAGA, NATALIA A.; MECAWI, ANDRE S.; ANTUNES-RODRIGUES, JOSE; DE MARTINIS, BRUNO S.; PADOVAN, CLAUDIA M.; TIRAPELLI, CARLOS R.. Ethanol withdrawal increases oxidative stress and reduces nitric oxide bioavailability in the vasculature of rats. ALCOHOL, v. 49, n. 1, p. 47-56, . (13/00808-8, 13/15824-9)

LEITE, LETICIA N.; LACCHINI, RICCARDO; CARNIO, EVELIN C.; QUEIROZ, REGINA H.; TANUS-SANTOS, JOSE EDUARDO; DE OLIVEIRA, ANA M.; TIRAPELLI, CARLOS R.. Ethanol Consumption Increases Endothelin-1 Expression and Reactivity in the Rat Cavernosal Smooth Muscle. ALCOHOL AND ALCOHOLISM, v. 48, n. 6, p. 657-666, . (11/12911-2)

HIPOLITO, ULISSES V.; ROCHA, JULIANA T.; PALAZZIN, NATHALIA B.; RODRIGUES, GERSON J.; CRESTANI, CARLOS C.; CORREA, FERNANDO M.; BONAVENTURA, DANIELLA; AMBROSIO, SERGIO R.; BENDHACK, LUSIANE M.; RESSTEL, LEONARDO B.; et al. The semi-synthetic kaurane ent-16 alpha-methoxykauran-19-oic acid induces vascular relaxation and hypotension in rats. European Journal of Pharmacology, v. 660, n. 2-3, p. 402-410, .

ROCHA, JULIANA T.; HIPOLITO, ULISSES V.; CALLERA, GLAUCIA E.; YOGI, ALVARO; DOS ANJOS NETO FILHO, MARIO; BENDHACK, LUSIANE M.; TOUYZ, RHIAN M.; TIRAPELLI, CARLOS R.. Ethanol induces vascular relaxation via redox-sensitive and nitric oxide-dependent pathways. VASCULAR PHARMACOLOGY, v. 56, n. 1-2, p. 74-83, .

DO VALE, GABRIEL T.; GONZAGA, NATALIA A.; SIMPLICIO, JANAINA A.; TIRAPELLI, CARLOS R.. Nebivolol prevents ethanol-induced reactive oxygen species generation and lipoperoxidation in the rat kidney by regulating NADPH oxidase activation and expression. European Journal of Pharmacology, v. 799, p. 33-40, . (15/22046-8)

SIMPLICIO, JANAINA A.; DO VALE, GABRIEL T.; GONZAGA, NATALIA A.; LEITE, LETICIA N.; HIPOLITO, ULISSES V.; PEREIRA, CAMILA A.; TOSTES, RITA C.; TIRAPELLI, CARLOS R.. Reactive oxygen species derived from NAD(P) H oxidase play a role on ethanol-induced hypertension and endothelial dysfunction in rat resistance arteries. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, v. 73, n. 1, p. 5-16, . (13/03965-7, 13/15824-9)

SIMPLICIO, JANAINA A.; GONZAGA, NATALIA A.; NAKASHIMA, MARCELO A.; DE MARTINIS, BRUNO S.; CUNHA, THIAGO M.; TIRAPELLI, LUIS F.; TIRAPELLI, CARLOS R.. Tumor necrosis factor-alpha receptor 1 contributes to ethanol-induced vascular reactive oxygen species generation and hypertension. JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION, v. 11, n. 10, p. 684-696, . (14/09595-0)

GONZAGA, NATALIA A.; AWATA, WANESSA M. C.; DO VALE, GABRIEL T.; MARCHI, KATIA C.; MUNIZ, JAQUELINE J.; TANUS-SANTOS, JOSE E.; TIRAPELLI, CARLOS R.. Perivascular adipose tissue protects against the vascular dysfunction induced by acute ethanol intake: Role of hydrogen peroxide. VASCULAR PHARMACOLOGY, v. 111, p. 44-53, . (10/05815-4)

DO VALE, GABRIEL T.; SIMPLICIO, JANAINA A.; GONZAGA, NATALIA A.; YOKOTA, RODRIGO; RIBEIRO, AMANDA A.; CASARINI, DULCE E.; DE MARTINIS, BRUNO S.; TIRAPELLI, CARLOS R.. Nebivolol prevents vascular oxidative stress and hypertension in rats chronically treated with ethanol. ATHEROSCLEROSIS, v. 274, p. 67-76, . (15/22046-8)

CERON, CARLA S.; DO VALE, GABRIEL T.; SIMPLICIO, JANAINA A.; PASSAGLIA, PATRICIA; RICCI, STHEFANY T.; TIRAPELLI, CARLOS R.. Data on the effects of losartan on protein expression, vascular reactivity and antioxidant capacity in the aorta of ethanol-treated rats. DATA IN BRIEF, v. 11, p. 111-116, . (10/05815-4)

AWATA, WANESSA M. C.; GONZAGA, NATALIA A.; BORGES, VANESSA F.; SILVA, CARLA B. P.; TANUS-SANTOS, JOSE E.; CUNHA, FERNANDO Q.; TIRAPELLI, CARLOS R.. Perivascular adipose tissue contributes to lethal sepsis-induced vasoplegia in rats. European Journal of Pharmacology, v. 863, . (17/24123-5)

DO VALE, GABRIEL T.; LEONI, DRIELI; SOUSA, ARTHUR H.; GONZAGA, NATALIA A.; ULIANA, DANIELA L.; LA GATA, DAVI C.; RESSTEL, LEONARDO B.; PADOVAN, CLAUDIA M.; TIRAPELLI, CARLOS R.. Acute restraint stress increases blood pressure and oxidative stress in the cardiorenal system of rats: a role for AT(1) receptors. STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, . (15/22046-8)

RESSTEL‚ L.; TIRAPELLI‚ C.R.; LANCHOTE‚ V.L.; UYEMURA‚ S.A.; DE OLIVEIRA‚ A.M.; CORR{\K{E}}A‚ F.. Chronic ethanol consumption alters cardiovascular functions in conscious rats. Life Sciences, v. 78, n. 19, p. 2179-2187, .

ROCHA, JULIANA T.; HIPOLITO, ULISSES V.; CALLERA, GLAUCIA E.; YOGI, ALVARO; DOS ANJOS NETO FILHO, MARIO; BENDHACK, LUSIANE M.; TOUYZ, RHIAN M.; TIRAPELLI, CARLOS R.. Ethanol induces vascular relaxation via redox-sensitive and nitric oxide-dependent pathways. VASCULAR PHARMACOLOGY, v. 56, n. 1-2, p. 74-83, . Web of Science Citations: 9.

COCO, HARIANE; PERNOMIAN, LARISSA; MARCHI, KATIA C.; GOMES, MAYARA S.; DE ANDRADE, CLAUDIA R.; RAMALHO, LEANDRA N. Z.; TIRAPELLI, CARLOS R.; DE OLIVEIRA, ANA M.. Consequence of hyperhomocysteinaemia on (1)-adrenoceptor-mediated contraction in the rat corpus cavernosum: the role of reactive oxygen species. Journal of Pharmacy and Pharmacology, v. 68, n. 1, p. 63-75, . Web of Science Citations: 4. (10/03614-1)

DE ANDRADE, CLAUDIA ROBERTA; TIRAPELLI, CARLOS RENATO; HADDAD, RENATO; EBERLIN, MARCOS N.; RAMALHO, LEANDRA N. Z.; IYOMASA, MAMIE M.; UYEMURA, SERGIO A.; DE OLIVEIRA, ANA MARIA. Hyperhomocysteinemia induced by feeding rats diets rich in DL-homocysteine thiolactone promotes alterations on carotid reactivity independent of arterial structure. VASCULAR PHARMACOLOGY, v. 51, n. 4, p. 291-298, . Web of Science Citations: 8.

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