graduation at Fisioterapia from Pontifícia Universidade Católica de Campinas (1988), master's at Biochemistry from Universidade Estadual de Campinas (2002) and doctorate at Clinical Medicine from Universidade Estadual de Campinas (2006). Has experience in Genetics, focusing on Human and Medical Genetics, acting on the following subjects: zebrafish, fluoro-jade, expressão gênica, epilepsia and candidate locus. (Source: Lattes Curriculum)
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This project will consolidate a new field of study in our Institution: the zebrafish model for functional investigations of genes related to human neurological disorders by genetic reverse techniques and phenotypic assessment. We hope contribute to a better understanding of the molecular mechanisms underlying the seizures by applying high throughput techniques to investigate microRNAs pro…
(Only some records are available in English at this moment)
Epilepsy is a neurological disease characterized by the presence of spontaneous and recurrent seizures that affect around 70 million people worldwide. Although the vast majority of patients respond well to drug therapy, approximately 30% are pharmacoresistant. Pharmacoresistance in epilepsy is associated with reduced quality of life and an increased risk of sudden death. Therefore there i…
Animal models have been contributing to a better understanding of the mechanisms underlying epilepsies. Recently, zebrafish larvae were described as a model of hyperthermia-induced seizures presenting abnormal electrographic activities. Despite its significance, this study was conducted using agar-immobilized larvae, and to better characterize the model per se, it is important to describe…
The main aim of this study is to investigate whether there is a direct relationship between age, in which the seizure is induced, and the transcript levels of il1b gene. To achieve this objective, seizures will be evoked by Pentylenetetrazole in zebrafish at 15 and 30 days post-fertilization, and the brain transcript levels quantified by Real-Time PCR. This study is part of a larger proje…
(Only some records are available in English at this moment)
Lafora Disease (LD) is a severe form of myoclonic epilepsy, characterized by early-adolescence onset and significant neurodegeneration that progress to dementia and ataxia, leading to death within 10 years. Mutations in two genes, EPM2A and the NHLRC1 have been identified to be responsible for this disease. Recently, it has been shown an increase of inflammatory mediators along with the L…
| 4 / 4 | Completed research grants |
| 7 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 12 / 9 | All research grants and scholarships |
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CV Lattes
ORCID