Graduate at Química from Universidade Estadual Paulista Júlio de Mesquita Filho (1996), master's at Chemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (1999) and Ph.D. at Chemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (2003). Has experience in Chemistry, focusing on Fields of Coordination, acting on the following subjects: amino acids, metals in medicine and bioinorganic chemistry . (Source: Lattes Curriculum)
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Ovarian cancer is one of the most common in women. Depending on the patient's conditions, the treatment may include surgery, radiotherapy, immunotherapy and chemotherapy, the last one including platinum(II) complexes such as cisplatin. However, platinum drugs present limitations during treatment, such as development of resistance and adverse effects. For this reason, the search for new an…
Several diseases caused by bacteria of different species, as well as those caused by some types of viruses, such as influenza and dengue, are a case of concern. Epidemiological data estimate 3 to 5 million cases of influenza per year and approximately 290 to 650 thousand deaths. The symptoms caused by severe cases of influenza are similar to the symptoms caused by dengue fever, which is a…
The discovery and the rational use of antimicrobial agents in the treatment of several infections brought a significant improvement in the life quality of patients. However, the indiscriminate use antimicrobial agents, including sulfonamides, has led to the appearance of multi-resistant bacterial strains, leading to the search for new drugs. One of the strategies to develop new antibacter…
(Only some records are available in English at this moment)
The growing demand for new alternatives in the treatment of infectious diseases makes the search for new drugs with antibacterial, antifungal, and antiviral action extremely important. The modification of existing drugs or their combination with other species active on microorganisms is an interesting strategy to obtain new molecules with the potential for clinical use. Amantadine and mem…
Metal complexes are currently used in medicine for both diagnosis and treatment of diseases. There are known, for example, the applications of technetium complexes as diagnostic agents for tumors, gold complexes in the treatment of rheumatoid arthritis, platinum(II) complexes as antitumoral agents, silver complexes as antimicrobial agents, lithium complexes in the treatment of disorders p…
Studies focused on the development of new metallodrugs have increased considerably in recent years due to the potential of application of such compounds in the medical field. These applications come from their structural characteristics and forms of interaction with biomolecules. Among some of the metals used in medicine are palladium and platinum, which in recent studies have shown to be…
The use of metals in medicine has been known since antiquity. However, until the end of the XIX century, this application was made empirically, without scientific evidence. Currently, metal complexes are employed clinically, and rationally, both in diagnosis and in the treatment of diseases. Some metal ions of recognized biological action, such as Ag(I), Cu(II), Pd(II) and Pt(II), also ca…
(Only some records are available in English at this moment)
Polynuclear platinum(II) complexes are promising chemotypes for the development of new anticancer agents with distinct mechanisms of action when compared to cisplatin-derived mononuclear complexes. Triplatin BBR3464 is a successful polynuclear Pt(II) complex, the only non-cisplatin analog to reach Phase II human clinical trials. However, pharmacokinetic issues derived from thiol nucleophi…
| 1 / 1 | Ongoing research grants |
| 6 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 22 / 16 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 31 / 24 | All research grants and scholarships |
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