bachelor's at Farmácia Bioquímica from Universidade de São Paulo (1991), master's at Applied Imunology from Universidade de São Paulo (1997) and doctorate at Applied Imunology from Universidade de São Paulo (2002). Has experience in Biochemistry, acting on the following subjects: apoptosis, apoptose, bcr-abl, chronic myelogenous leukemia and leucemia mieloide crônica. (Source: Lattes Curriculum)
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Myeloproliferative neoplasms (MPN) are hematological disorders characterized by increased cell proliferation and accumulation of mature and precursor myeloid cells in bone marrow and peripheral blood independently of cytokine stimuli and growth factors. The discovery of genetic mutations linked to this disorders development, since 2005, has been contributed to the understanding of the pat…
Animal venoms constitute a rich source of pharmacologically active substances. Such molecules, named toxins, act either isolated or in synergy through the binding to cell receptors and/or interfering metabolic pathways fundamental to cell viability, inducing local, systemic and even lethal damage to the victim or pray. Exploring the mechanisms of action of toxins has been relevant for pro…
Polycythemia Vera (PV), Essential Thrombocytosis (ET), and Primary Myelofibrosis (PMF) are Ph-negative chronic myeloproliferative neoplasms characterized by the either the presence of progenitors independence or by hypersensitive to numerous cytokines associated with cell differentiation and intense proliferation. The cellular and molecular mechanisms involved in the pathogenesis and prog…
Myeloproliferative Neoplasms (MPNs) are clonal hematological disorders resulting from genetic mutations in the hematopoietic stem cell that promotes cellular hyperproliferation and accumulation of precursor and mature myeloid cells in the bone marrow and peripheral blood. The classic negative BCR-ABL1 MPNs, in this work, are represented by the neoplasms Polycythemia Vera (PV), Essential T…
Myeloproliferative neoplasms (MPN) are hematological disorders characterized by increased cell proliferation and accumulation of mature and precursor myeloid cells in peripheral blood independently of cytokine stimuli and growth factors.The discovery of genetic mutations since 2005 has contributed to the elucidation of the physiopathology of MPN. However, despite the knowledge accumulated…
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Circular RNAs (circRNAs) are a large class of particularly stable RNAs which are conserved in animals and have complex stage and tissue-specific expression patterns. CircRNAs are generated by a back-splicing reaction, in which a 5' splice site covalently ligates to an upstream 3' splice site. Recent studies have demonstrated novel capabilities of circRNAs as gene regulators in mammals mai…
Myeloproliferative neoplasms (MPN) are haematological disorders characterized by increased proliferation and accumulation of mature myeloid cells of one or more of the myeloid series (granulocytic, erythroid or megakaryocytic). Among the MPN are polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). Patients with these disorders may present the JAK2V617F m…
ThiThe acute myeloid leukemias (AML) are clonal hematopoietic disorders characterized by myeloaccumulation of immature myeloid cells. The AML categorization define AML with Favorable, Intermediate I, Intermediate II and Adverse risk according the karyotype anomaly, genetic alterations, overall patient survival, post- treatment relapse risk and patients' response to treatment. Although all…
| 5 / 3 | Completed research grants |
| 15 / 10 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 23 / 16 | All research grants and scholarships |
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CV Lattes
ORCID