graduation at Curso de Ciências Moleculares from Universidade de São Paulo (1994), master's at Physic from Universidade de São Paulo (1997) and doctorate at Physic from Universidade de São Paulo (2001). Has experience in Byophysics, focusing on Molecular Biophysics (Source: Lattes Curriculum)
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Differential scanning calorimetry is a technique that allows the measurement of the specific heat of a sample subjected to a temperature scan. This technique has been widely used to relate thermal properties of materials with their physical properties. In special, the DSC technique is traditionally used in the topics proposed in the Thematic Project to which this proposal is linked, such …
Fluorescence is one of the most versatile techniques applied in biophysical studies. The fluorescence lifetime is on the order of nanoseconds, coinciding with the timescale of several relevant processes at the molecular level, such as conformational changes of biomolecules. The fluorescence can be directly measured in biomolecules such as proteins and peptides that have fluorescent aminoa…
Lipid and polymeric nanostructured systems are self-assembled systems with characteristic sizes in the nanometric scale. Among them, liposomes, nanoparticles, emulsions and continuous phases can be highlighted. Liposomes have been widely employed as mimetic models of biological membranes, due to their easy manipulation and for allowing precise control of the system components. Therefore, …
Lipid bilayers have been extensively used as model systems of cellular membranes, with the purpose of studying in a controlled and independent way fundamental aspects of biological process involving membranes. The focus of this project is to study properties of negatively charged lipid bilayers when exposed to different perturbations: electric pulses, cationic vesicles and antimicrobial p…
Detergents are routinely used to solubilize the components of cell membranes, whose structural motif is given by the lipid phase. Therefore, the study of the physicochemical aspects of the detergent/lipid interaction is important both for a better understanding of the solubilization process and for the proposition of more efficient solubilization protocols. Most of these studies, however,…
The selection of microorganisms resistant to conventional drugs, caused mainly by the indiscriminate use of antibiotics, is a problem in the world health scenario, which has led the scientific community to seek new therapeutic strategies. Antimicrobial Peptides (AMPs) are naturally modulators of the innate immune system of several organisms and have been shown to be a promising alternativ…
Unconventional food plants (UFPs) were described by the biologist Valderly Kinupp as native or exotic edible plants that can be found in backyards, flowerbeds and vacant lots. In Brazil, it is estimated that at least 10% of the native flora is food, totaling an average of 5,000 species. In addition, they are classified as functional foods, as they are rich sources of essential vitamins, a…
Liposomes have been used as a drug delivery system in biological media. However, conventional liposomes typically enter the cell via endocytic routes, making it difficult to deliver the encapsulated material to the intracellular medium. To optimize direct intracellular delivery, a fusogenic liposomal system was recently developed. This system has presented high fusion efficiency with both…
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Liposomes are reliable biomimetic models of the complex biological membrane and have a great potential as drug delivery systems. Fusogenic liposomes, based on cationic (e.g. DOTAP) and fusion promoter (e.g. DOPE) lipids, are interesting delivery systems because of their effective intracellular delivery of encapsulated materials, in comparison with conventional liposomes that usually under…
The possibility to study functioning mechanisms and the complexity of a biological system using self-organized systems is of great interest in the scientific community. A major part of the biological processes take place at the biological membrane interface and its modeling with Langmuir monolayers and lipid bilayers are valuable because of their easy preparation and molecular control. Th…
Giant unilamellar vesicles (GUVs) are a good model of biological membranes for the investigation of biological processes. Their use allows observation of the studied events by optical microscopy. In this project, we propose to study various biophysical aspects of GUVs composed of negatively charged lipids in the presence of an electric field - electrical pulse, and during fusion with memb…
| 2 / 2 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 11 / 8 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 22 / 17 | All research grants and scholarships |
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CV Lattes
ORCID