Graduated from Universidade Estadual de Londrina (1986) with a degree in Pharmacy. Completed a master's degree and a PhD degree in Biochemistry from Universidade de São Paulo (1993). Postdoctoral training at the Harvard Medical School and Washington University at Saint Louis (1998). Is the Principal Investigator of the Laboratory of Molecular Biology of Leishmanias at the Department of Cell Biology of the Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo. Coordinates projects that are focused on the study of the DNA damage response and its role in genome plasticity in the protozoan parasite Leishmania. (Source: Lattes Curriculum)
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Leishmaniasis is a devastating parasitic disease that targets the poorest of society and is the 9th largest global infectious disease burden (WHO). It is truly a Neglected Infectious Disease as the combined financial support of basic and clinical research equates to <2% of infectious disease R&D resources available. Consequently, there are no vaccines available currently and the limited a…
Pathogenic trypanosomatids such as Leishmania spp. and Trypanosoma cruzi are the causative agents of leishmaniosis and Chagas disease, a group of neglected diseases endemic in the tropical and subtropical belt of the planet and the Americas, respectively. The therapeutic approaches against these diseases are largely unsatisfactory due to toxicity and emergence of resistance. Thus, new dru…
Our laboratory has contributed to the understanding of DNA damage signaling pathways in the protozoan parasite Leishmania. The study of the detection and signaling of DNA damage in an early-diverging eukaryote can further our understanding of how DNA Damage Response (DDR) has been established in the eukaryotic line. Based on the identification and characterization of checkpoint proteins R…
Recent work in Leishmania examined a key player in the damage sensing, cell cycle progression and DNA repair processes in these organisms. This factor, termed the Rad9-Rad1-Hus1 (9-1-1) complex is a ring-shaped heterotrimeric complex, structurally related to the PCNA clamp and is conserved amongst eukaryotes. Accumulating evidence indicates Leishmania 9-1-1 is central to genome maintenanc…
(Only some records are available in English at this moment)
The genome of Leishmania is characterized by a remarkable plasticity that has been associated with the acquisition of drug resistance and with host adaptation. Here, we will explore if the parasite's signaling of replication 'stress' may underlie genome plasticity and diversity. The analysis of the ATR pathway, which is central to the detection and signaling DNA replication stress and dam…
Considering that DNA damage is an important modulator of chromatin states, our aim is not only to evaluate the existence of genomic sites of recurrent replication stress or DNA damage, but also characterize the chromatin environment associated to these sites in Trypanosoma cruzi and Leishmania major. (AU)
Little is known about the kinase ATR role in the homeostasis of the genome of primitive eukaryotes, such as trypanosomatids. In other eukaryotes, ATR participates in the signaling of DNA damaged structures, mainly through the phosphorylation of Chk1 and subsequent cell cycle arrest. The main objective of this project is to investigate the conservation of ATR kinase in Leishmania and explo…
In this project we propose to characterize the Leishmania ATR kinase, a central factor in response to replicative stress in other eukaryotes. For this, we will generate an ATR-deficient cell line and carry out the functional characterization of the protein. We will also use high-throughput approaches to study the effect of ATR deficiency in the overall response to replicative stress. For …
(Only some records are available in English at this moment)
The eukaryotic cell has developed mechanisms to maintain genome integrity, which are constantly challenged by DNA damage and replication impediments. The protein kinase Ataxia-Telangiectasia and Rad3-related (ATR), a member of the phosphatidylinositol 3-kinase-like family, is a master regulator of the eukaryotic response to DNA injuries to ensure genome maintenance and stability. In this …
Eukaryote cells have developed mechanisms to coordinate DNA damage sensing, cell cycle arrest and DNA damage repair in order to grant genome stability. In higher eukaryotes, the 9-1-1 checkpoint complex, composed by the proteins Rad9, Rad1 and Hus1, participates in the early steps of the DNA damage response. We have identified possible homologues of each one of the three subunits of the 9…
| 1 / 1 | Ongoing research grants |
| 11 / 8 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 20 / 7 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 36 / 19 | All research grants and scholarships |
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CV Lattes
ORCID