CV Lattes
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ORCID
Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation for the last research proposal) Birthplace: Alemanha
Is currently a Full professor at UNICAMP, School of Pharmaceutical Sciences, Graduated in Biologia from Universitat Kiel (Christian-Albrechts) (1992), master's in Biology from Universitat Kiel (Christian-Albrechts) (1992) and Ph.D. in Biology from Universitat Kiel (Christian-Albrechts) (1995), Was a researcher and group leader between 1998-2014 at the CNPEM/LNBio - Campinas (former Brazilian Synchrotron laboratory), Habilitated (Privatdozent, livre docente) in 2013 at Universidade São Paulo. Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: cancer, onco-proteins, signaling, protein-protein interactions and cancer signaling. Published 96 papers. Tutored 24 PhD and 6 master students. Co-supervised 4 PhD and supervised 13 post-docs and 23 undergraduate students in the past. In the moment tutors 5 PhD students, 1 undergraduate student and supervises 3 post-docs. (Source: Lattes Curriculum)
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Members of the family of NEK kinases (NIMA related kinases) were identified as important regulators of cell cycle checkpoints, especially at the G2 to M phase transition. Although they are among all kinases one of the least studied families, recent studies showed they can have crucial roles in mitosis, centrosome disjunction, and in the signaling of the DNA damage response. These characte…
Ki-1/57 was discovered through the cross-reactivity of the monoclonal antibody Ki-1, the first antibody which specifically detects the cells of the Hodgkin lymphome. Preliminary studies on this protein revealed several characteristics that are common to onco-proteins. Yeast-two hybrid experiments identified interacting proteins involved in the control of transcription and RNA metabolism.…
The proteín UNC-76 was identified as an essential component for axon fasciculation and elongation in the worm Caenorhabditis elegans. In the same way, the orthologue from mammalians FEZ1 presents expression in neuronal tissues and knockout mice for the FEZ1 gene present comportamental disorders which reflect light neurological defects. In previous work our group has shown that FEZq is a m…
Normal cells generate high amounts of ATP by metabolizing glucose completely to carbon dioxide. In contrast, rapidly growing cancer cells restrict this metabolic pathway and profit from intermediate products for the biosynthesis of cell components and to influence the microenvironment. The lower molar ATP yield is compensated by increased glucose consumption. This metabolic switch is crit…
(Only some records are available in English at this moment)
Centrioles assemble the centrosome, the microtubule organizing centre essential for cell division in proliferating cells. Centrioles also template cilia, cell organelles that act as antenna in quiescent cells and can also generate fluid flow. Because of their essential functions in human life, centrioles are highly regulated throughout the cell cycle. Among the least studied centriole cyc…
The members of the Nek kinases (NIMA related kinases) family, were identified as important regulators of cell cycle checkpoints, especially in the G2 transition to M. Although it is one of the families of less studied kinases, recent studies have shown that they may have critical roles in mitosis, separation of centrioles and signaling pathways for DNA damage. These characteristics couple…
(Only some records are available in English at this moment)
1983 Oakley and Morris identified, in a genetic cell division screen, in the filamentous fungus Aspergillus nidulans, a protein kinase named NIMA (Never In Mitosis gene A), founding member of the NEK family kinases (NIMA related kinases). The NEKs were identified in a vast spectrum of organisms, from protozoans to multicellular eukaryonts, including Drosophila, Xenopus, mice and humans. H…
Neks (Nima-Related Kinases) are a family of kinase proteins with important functions in cell cycle regulation, DNA damage response, and primary ciliary function. Nek4 has already been related to these three functions, but its role in these biological processes is not yet elucidated. Previous data demonstrated that Nek4 interacts with non-homologous end joining (NHEJ) proteins and that cel…
Neks are serine-threonine kinases that are similar to NIMA, a protein found in Aspergillus nidulans which is essential for cell division. Eleven human Neks have been identified (1-11) and there is growing evidence pointing Neks role in diverse cellular process, such as cell cycle control, including cell division, mitotic spindle assembly, furrow ingression, primary cilium formation and ma…
(Only some records are available in English at this moment)
The eleven members of the human NEK family of serine/threonine kinases have been associated with diverse cellular processes. The function of NEK10 is poorly understood, but we have recently found that NEK10 has a role in mitochondrial morphology and function. NEK10 has several isoforms and we were able to identify at least one which is enriched in mitochondria. Immunoprecipitation followe…
Nek4 is a serine/threonine kinase that has already been implicated in primary cilia stabilization, DNA damage response, autophagy, and epithelia-mesenchymal transition. The role of Nek4 in cancer cell survival and chemotherapy resistance has also been shown. However, the precise mechanisms by which Nek4 operates remain to be elucidated. Our previous results have shown that Nek4 interacts …
NEKs (Nima Related Kinases) family is one of poorest characterized mitotic kinases family and plays important roles not only in the cell cycle but also in DNA Damage Response and other functions apart from the cell cycle such as regulation of cytosolic and mitochondrial proteins, regulation of apoptosis and autophagy. Therefore, these kinases have the potential to become important therape…
Nek1 protein belongs to the NIMA-related kinases or "Neks" family, which consists of eleven proteins named Nek1 to Nek 11. These paralogs have been functionally associated with mitosis, cilium regulation and the DNA damage response (DDR). Defects in DNA repair is suggested in Nek1-deficient cells by the persistence of DNA double-strand breaks (DSBs) following exposure to ionizing radiatio…
Human Nek10 is a not completely characterized Nek family member that is implicated as a player in different types of cancer. We previously showed that Nek10 is localized to centrosome and provided the first evidences of its roles in regulating mitotic centrosome and spindle function and its potential connection with genomic instability. However, exact Nek10 roles in regulating mitotic-cen…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 9 / 9 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 58 / 35 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 10 / 10 | Completed scholarships abroad |
| 85 / 62 | All research grants and scholarships |
| Associated processes | |
RUI‚ E.; DE MOURA‚ P.R.; KOBARG‚ J.. Expression of deletion mutants of the hepatitis B virus protein HBx in< i> E. coli and characterization of their RNA binding activities. VIRUS RESEARCH, v. 74, n. 1, p. 59-73, 2001. (98/05891-9)
BRESSAN, GUSTAVO COSTA; KOBARG, JOERG. From protein interaction profile to functional assignment The human protein Ki-1/57 is associated with pre-mRNA splicing events. RNA BIOLOGY, v. 7, n. 3, p. 268-271, MAY-JUN 2010. (08/04849-2)
ASSMANN, ELIANA M.; ALBORGHETTI, MARCOS R.; CAMARGO, MARIA E. R.; KOBARG, JORG. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. Journal of Biological Chemistry, v. 281, n. 15, p. 9869-9881, Apr. 2006. (05/00235-1)
DE MOURA‚ P.R.; RUI‚ E.; DE ALMEIDA GONÇALVES‚ K.; KOBARG‚ J.. The cysteine residues of the hepatitis B virus onco-protein HBx are not required for its interaction with RNA or with human p53. VIRUS RESEARCH, v. 108, n. 1, p. 121-131, 2005. (98/05891-9)
MORAIS, MARIANA A. B.; GIUSEPPE, PRISCILA O.; SOUZA, TATIANA A. C. B.; ALEGRIA, THIAGO G. P.; OLIVEIRA, MARCOS A.; NETTO, LUIS E. S.; MURAKAMI, MARIO T.. How pH Modulates the Dimer-Decamer Interconversion of 2-Cys Peroxiredoxins from the Prx1 Subfamily. Journal of Biological Chemistry, v. 290, n. 13, p. 8582-8590, MAR 27 2015. (12/24134-3, 10/51730-0, 11/10248-4)
VIEIRA, PLINIO SALMAZO; DE GIUSEPPE, PRISCILA OLIVEIRA; CAVALCANTE DE OLIVEIRA, ARTHUR HENRIQUE; MURAKAMI, MARIO TYAGO. The role of the C-terminus and Kpn loop in the quaternary structure stability of nucleoside diphosphate kinase from Leishmania parasites. Journal of Structural Biology, v. 192, n. 3, p. 336-341, DEC 2015. (11/20569-2, 11/24178-8, 07/06755-2, 10/03761-4, 10/51730-0)
VIEIRA, PLINIO SALMAZO; CAMPOS BRASIL SOUZA, TATIANA DE ARRUDA; HONORATO, RODRIGO VARGAS; ZANPHORLIN, LETICIA MARIA; SEVERIANO, KELVEN ULISSES; ROCCO, SILVANA APARECIDA; CAVALCANTE DE OLIVEIRA, ARTHUR HENRIQUE; CORDEIRO, ARTUR TORRES; LOPES OLIVEIRA, PAULO SERGIO; DE GIUSEPPE, PRISCILA OLIVEIRA; et al. Pyrrole-indolinone SU11652 targets the nucleoside diphosphate kinase from Leishmania parasites. Biochemical and Biophysical Research Communications, v. 488, n. 3, p. 461-465, JUL 1 2017. (11/20569-2, 11/24178-8, 07/06755-2, 10/03761-4, 10/51730-0)
SIMABUCO, FERNANDO MOREIRA; TAMURA, RODRIGO ESAKI; BETIM PAVAN, ISADORA CAROLINA; MORALE, MIRIAN GALLIOTE; VENTURA, ARMANDO MORAIS. Molecular mechanisms and pharmacological interventions in the replication cycle of human coronaviruses. GENETICS AND MOLECULAR BIOLOGY, v. 44, n. 1, 1, 2021. (19/15619-2, 16/25139-0, 18/08391-2, 18/14818-9, 20/05346-6)
PERES DE OLIVEIRA, ANDRESSA; BASEI, FERNANDA LUISA; SLEPICKA, PRISCILA FERREIRA; DE CASTRO FEREZIN, CAMILA; MELO-HANCHUK, TALITA D.; DE SOUZA, EDMARCIA ELISA; LIMA, TANES I.; DOS SANTOS, VALQUIRIA TIAGO; MENDES, DAVI; SILVEIRA, LEONARDO REIS; et al. NEK10 interactome and depletion reveal new roles in mitochondria. PROTEOME SCIENCE, v. 18, n. 1, APR 28 2020. (14/15982-6, 18/05350-3, 17/03489-1)
DE OLIVEIRA, ANDRESSA PERES; ISSAYAMA, LUIDY KAZUO; BETIM PAVAN, ISADORA CAROLINA; SILVA, FERNANDO RIBACK; MELO-HANCHUK, TALITA DINIZ; SIMABUCO, FERNANDO MOREIRA; KOBARG, JORG. Checking NEKs: Overcoming a Bottleneck in Human Diseases. Molecules, v. 25, n. 8, APR 2 2020. (17/03489-1, 14/15982-6, 18/14818-9)
MELO-HANCHUK, TALITA DINIZ; SLEPICKA, PRISCILA FERREIRA; PELEGRINI, ALESSANDRA LUIZA; MARTINS MENCK, CARLOS FREDERICO; KOBARG, JORG. NEK5 interacts with topoisomerase II beta and is involved in the DNA damage response induced by etoposide. Journal of Cellular Biochemistry, v. 120, n. 10, p. 16853-16866, OCT 2019. Web of Science Citations: 0. (14/15982-6, 17/03489-1, 10/51730-0, 15/06458-4, 10/16831-0, 10/15262-2)
MELO-HANCHUK, TALITA D.; SLEPICKA, PRISCILA FERREIRA; MEIRELLES, GABRIELA VAZ; BASEI, FERNANDA LUISA; LOVATO, DIOGO VENTURA; GRANATO, DANIELA CAMPOS; PAULETTI, BIANCA ALVES; DOMINGUES, ROMENIA RAMOS; PAES LEME, ADRIANA FRANCO; PELEGRINI, ALESSANDRA LUIZA; et al. NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin. SCIENTIFIC REPORTS, v. 7, JUL 14 2017. Web of Science Citations: 4. (10/51730-0)
ASSMANN, ELIANA M.; ALBORGHETTI, MARCOS R.; CAMARGO, MARIA E. R.; KOBARG, JORG. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. Journal of Biological Chemistry, v. 281, n. 15, p. 9869-9881, Apr. 2006. (05/00235-1)
QUARESMA, ALEXANDRE J. C.; BRESSAN, G. C.; GAVA, L. M.; LANZA, D. C. F.; RAMOS, C. H. I.; KOBARG, JOERG. Human hnRNP Q re-localizes to cytoplasmic granules upon PMA, thapsigargin, arsenite and heat-shock treatments. Experimental Cell Research, v. 315, n. 6, p. 968-980, APR 1 2009. Web of Science Citations: 23. (05/00235-1)
BRESSAN, GUSTAVO C.; SILVA, JULIO C.; BORGES, JULIO C.; DOS PASSOS, DARIO O.; RAMOS, CARLOS H. I.; TORRIANI, IRIS L.; KOBARG, JOERG. Human regulatory protein Ki-1/57 has characteristics of an intrinsically unstructured protein. JOURNAL OF PROTEOME RESEARCH, v. 7, n. 10, p. 4465-4474, OCT 2008. Web of Science Citations: 14. (05/00235-1)
RUI‚ E.; DE MOURA‚ P.R.; KOBARG‚ J.. Expression of deletion mutants of the hepatitis B virus protein HBx in< i> E. coli and characterization of their RNA binding activities. VIRUS RESEARCH, v. 74, n. 1, p. 59-73, 2001. (98/05891-9)
BRESSAN, GUSTAVO COSTA; KOBARG, JOERG. From protein interaction profile to functional assignment The human protein Ki-1/57 is associated with pre-mRNA splicing events. RNA BIOLOGY, v. 7, n. 3, p. 268-271, MAY-JUN 2010. Web of Science Citations: 3. (08/04849-2)
DE MOURA‚ P.R.; RUI‚ E.; DE ALMEIDA GONÇALVES‚ K.; KOBARG‚ J.. The cysteine residues of the hepatitis B virus onco-protein HBx are not required for its interaction with RNA or with human p53. VIRUS RESEARCH, v. 108, n. 1, p. 121-131, 2005. (98/05891-9)
LANZA, DANIEL C. F.; SILVA, JULIO C.; ASSMANN, ELIANA M.; QUARESMA, ALEXANDRE J. C.; BRESSAN, GUSTAVO C.; TORRIANI, IRIS L.; KOBARG, JOERG. Human FEZ1 has characteristics of a natively unfolded protein and dimerizes in solution. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, v. 74, n. 1, p. 104-121, JAN 2009. Web of Science Citations: 23. (05/00235-1)
RUI, EDMILSON; MOURA, PATRICIA RIBEIRO DE; GONÇALVES, KALIANDRA DE ALMEIDA; KOBARG, JÖRG. Expression and spectroscopic analysis of a mutant hepatitis B virus onco-protein HBx without cysteine residues. Journal of Virological Methods, v. 126, n. 1/2, p. 65-74, June 2005. (98/05891-9)
MELO-HANCHUK, TALITA D.; SLEPICKA, PRISCILA FERREIRA; MEIRELLES, GABRIELA VAZ; BASEI, FERNANDA LUISA; LOVATO, DIOGO VENTURA; GRANATO, DANIELA CAMPOS; PAULETTI, BIANCA ALVES; DOMINGUES, ROMENIA RAMOS; PAES LEME, ADRIANA FRANCO; PELEGRINI, ALESSANDRA LUIZA; et al. NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin. SCIENTIFIC REPORTS, v. 7, JUL 14 2017. (10/51730-0)
BASEI, FERNANDA L.; MOURA, LIVIA A. R.; KOBARG, JORG. Using the E1A Minigene Tool to Study mRNA Splicing Changes. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, n. 170, APR 2021. (17/03489-1, 18/05350-3)
LANZA‚ D.C.F.; TRINDADE‚ D.M.; ASSMANN‚ E.M.; KOBARG‚ J.. Over-expression of GFP-FEZ1 causes generation of multi-lobulated nuclei mediated by microtubules in HEK293 cells. Experimental Cell Research, v. 314, n. 10, p. 2028-2039, 2008. (05/00235-1)
RUI, EDMILSON; MOURA, PATRICIA RIBEIRO DE; GONÇALVES, KALIANDRA DE ALMEIDA; KOBARG, JÖRG. Expression and spectroscopic analysis of a mutant hepatitis B virus onco-protein HBx without cysteine residues. Journal of Virological Methods, v. 126, n. 1/2, p. 65-74, June 2005. (98/05891-9)
TEIXEIRA, MARIANA BERTINI; FIGUEIRA, ANA CAROLINA M.; FURLAN, ARIANE S.; AQUINO, BRUNO; ALBORGHETTI, MARCOS R.; LEME, ADRIANA F. PAES; WEI, LI-NA; KOBARG, JORG. Fasciculation and elongation zeta-1 protein (FEZ1) interacts with the retinoic acid receptor and participates in transcriptional regulation of the Hoxb4 gene. FEBS OPEN BIO, v. 8, n. 1, p. 4-14, JAN 2018. (12/18796-3, 12/00792-1, 15/11059-1)
ALVES BARBOSA, EVERTON DE ALMEIDA; SERAPHIM, THIAGO VARGAS; GANDIN, CESAR AUGUSTO; TEIXEIRA, LEILANE FERREIRA; GONCALVES DA SILVA, RONNI ANDERSON; RIGHETTO, GERMANNA L.; GONCALVES, KALIANDRA DE ALMEIDA; VASCONCELLOS, RAPHAEL DE SOUZA; ALMEIDA, MARCIA ROGERIA; SILVA JUNIOR, ABELARDO; et al. Insights into the full-length SRPK2 structure and its hydrodynamic behavior. International Journal of Biological Macromolecules, v. 137, p. 205-214, SEP 15 2019. (14/07206-6, 13/50724-5, 11/23110-0, 12/00195-3, 17/03489-1, 12/50161-8, 17/07335-9)
DE SOUZA, EDMARCIA ELISA; HEHNLY, HEIDI; PEREZ, ARINA MARINA; MEIRELLES, GABRIELA VAZ; COSTA SMETANA, JULIANA HELENA; DOXSEY, STEPHEN; KOBARG, JOERG. Human Nek7-interactor RGS2 is required for mitotic spindle organization. CELL CYCLE, v. 14, n. 4, p. 656-667, FEB 15 2015. (10/51730-0)
PEREZ, ARINA MARINA; AQUINO, BRUNO; VIVIANI, VADIM; KOBARG, JORG. Use of a special Brazilian red-light emitting railroad worm Luciferase in bioassays of NEK7 protein Kinase and Creatine Kinase. BMC BIOCHEMISTRY, v. 18, JUL 19 2017. (11/20086-1, 13/09594-0, 14/21700-3, 12/22265-3)
SAITO, ANGELA; SOUZA, EDMARCIA E.; COSTA, FERNANDA C.; MEIRELLES, GABRIELA V.; GONCALVES, KALIANDRA A.; SANTOS, MARCOS T.; BRESSAN, GUSTAVO C.; MCCOMB, MARK E.; COSTELLO, CATHERINE E.; WHELAN, STEPHEN A.; et al. Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation. JOURNAL OF PROTEOME RESEARCH, v. 16, n. 9, p. 3147-3157, SEP 2017. (14/21700-3)
MARTINS, MARIANA BONJIORNO; PEREZ, ARINA MARINA; BOHR, VILHELM A.; WILSON, III, DAVID M.; KOBARG, JORG. NEK1 deficiency affects mitochondrial functions and the transcriptome of key DNA repair pathways. MUTAGENESIS, v. 36, n. 3, p. 223-236, MAY 2021. (16/02040-8, 14/15982-6, 17/21067-7, 17/03489-1)
CASTELUCCI, B. G.; PEREIRA, A. H. M.; FIORAMONTE, M.; CARAZZOLLE, M. F.; DE OLIVEIRA, P. S. L.; FRANCHINI, K. G.; KOBARG, J.; MARTINS-DE-SOUZA, D.; JOAZEIRO, P. P.; CONSONNI, S. R.. Evidence of macrophage modulation in the mouse pubic symphysis remodeling during the end of first pregnancy and postpartum. SCIENTIFIC REPORTS, v. 10, n. 1, JUL 24 2020. (15/23616-2, 17/03489-1)
MELO-HANCHUK, TALITA DINIZ; MARTINS, MARIANA BONJIORNO; CUNHA, LUCAS LEITE; SOARES, FERNANDO AUGUSTO; WARD, LAURA STERIAN; VASSALLO, JOSE; KOBARG, JORG. Expression of the NEK family in normal and cancer tissue: an immunohistochemical study. BMC CANCER, v. 20, n. 1, JAN 6 2020. (15/06458-4, 17/03489-1, 16/02040-8)
BETIM PAVAN, ISADORA CAROLINA; DE OLIVEIRA, ANDRESSA PERES; FIRMINO DIAS, PEDRO RAFAEL; BASEI, FERNANDA LUISA; ISSAYAMA, LUIDY KAZUO; FEREZIN, CAMILA DE CASTRO; SILVA, FERNANDO RIBACK; RODRIGUES DE OLIVEIRA, ANA LUISA; ALVES DOS REIS MOURA, LIVIA; MARTINS, MARIANA BONJIORNO; et al. On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage Response. CELLS, v. 10, n. 3, MAR 2021. (16/02040-8, 17/21067-7, 17/03489-1)
(References retrieved automatically from State of São Paulo Research Institutions)
PAPA, Priscila Ferreira. Caracterização das proteínas hNek5 e hNek10 no contexto da resposta do dano no DNA = uma abordagem funcional e interactômica = Characterization of the hNek5 and hNek10 proteins in the DNA damage response context : a functional and interatomic approach. Tese (Doutorado) - Universidade Estadual de Campinas, Instituto de Biologia. (10/15262-2)
HANCHUK, Talita Diniz Melo. Caracterização funcional : a cinase humana Nek5 interfere negativamente na morte celular e no processo de poliglutamilação = Functional characterization : the human kinase Nek5 interferes negatively in cell death and the polyglutamylation process. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas. (10/16831-0)
MORAES, Karen Cristiane Martinez de. Estudo funcional e estrutural da proteina humana AUF1. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas. (99/07423-5)
SOUZA, Edmarcia Elisa de. A Nek7 é uma quinase multifuncional que atua sobre diferentes processos biológicos e em concerto com a sinalização da divisão celular = : Nek7 is a multifunctional kinase that acts on different biological processes and in concert with the cell division signaling. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas. (09/11912-5)
MOURA, Patricia Ribeiro de. Analise funcional e estrutural da proteina HBx do virus da Hepatite B. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (01/00554-9)
BRESSAN, Gustavo Costa. Ki-1/57 e uma proteina intrinsecamente desordenada envolvida em mecanismos de regulação genica. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (04/13295-0)
MEIRELLES, Gabriela Vaz. Estudos estruturais e funcionais das proteínas cinases humanas Nek1 e Nek6. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (06/04683-1)
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LANZA, Daniel Carlos Ferreira. A proteina FEZ1 : pouca organização estrutural, atividades associadas a elementos do citoesqueleto e formação do fenotipo "flower like". Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (05/04104-9)
LEMOS, Taíla Andrade. Identificação de proteínas que interagem com a proteína CGI-55 para caracterização do seu contexto funcional. 94 f. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). Campinas. (00/02216-0)
MORAES, Eduardo Cruz. Seleção de compostos como candidatos para a inibição da atividade de proteínas cinases humanas da família das Neks. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (09/11680-7)
NERY, Flávia Cristina. Estudos funcionais e estruturais da proteina reguladora humana Ki-1/57. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas. (01/00555-5)
TEIXEIRA, Mariana Bertini. Fisiologia e patologia da proteína FEZ1 : caracterização da interação com receptor do ácido retinóico e avaliação da expressão em leucemia mielóide aguda = Physiology and pathology of protein FEZ1: characterization of the interaction with retinoic acid receptor and evaluation of its expression in acute myeloid leukemia. Tese (Doutorado) - Universidade Estadual de Campinas, Instituto de Biologia. (12/00792-1)
SOUZA, Edmarcia Elisa de. A Nek7 é uma quinase multifuncional que atua sobre diferentes processos biológicos e em concerto com a sinalização da divisão celular = : Nek7 is a multifunctional kinase that acts on different biological processes and in concert with the cell division signaling. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas. (09/11912-5)
MEIRELLES, Gabriela Vaz. Estudos estruturais e funcionais das proteínas cinases humanas Nek1 e Nek6. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (06/04683-1)
None
LANZA, Daniel Carlos Ferreira. A proteina FEZ1 : pouca organização estrutural, atividades associadas a elementos do citoesqueleto e formação do fenotipo "flower like". Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (05/04104-9)
LEMOS, Taíla Andrade. Identificação de proteínas que interagem com a proteína CGI-55 para caracterização do seu contexto funcional. 94 f. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). Campinas. (00/02216-0)
HANCHUK, Talita Diniz Melo. Caracterização funcional : a cinase humana Nek5 interfere negativamente na morte celular e no processo de poliglutamilação = Functional characterization : the human kinase Nek5 interferes negatively in cell death and the polyglutamylation process. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas. (10/16831-0)
MOURA, Patricia Ribeiro de. Analise funcional e estrutural da proteina HBx do virus da Hepatite B. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (01/00554-9)
SAITO, Angela. Estudos funcionais da proteína reguladora Ki-1/57 em células e camundongos = Functional studies of the regulatory protein Ki-1/57 in cells and mice. Tese (Doutorado) - Universidade Estadual de Campinas, Instituto de Biologia. (10/15760-2)
TRINDADE, Daniel Maragno. Estudos estruturais e funcionais da proteina stanniocalcina-1 humana, um novo marcador de microambiente de leucemia. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (04/13953-7)
RIGHETTO, Germanna Lima. SF2/ASF e SRPK2 : relação entre a maquinaria de splicing alternativo e o desenvolvimento da leucemia. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (10/12884-2)