CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Alemanha
Is currently a Full professor at UNICAMP, School of Pharmaceutical Sciences, Graduated in Biologia from Universitat Kiel (Christian-Albrechts) (1992), master's in Biology from Universitat Kiel (Christian-Albrechts) (1992) and Ph.D. in Biology from Universitat Kiel (Christian-Albrechts) (1995), Was a researcher and group leader between 1998-2014 at the CNPEM/LNBio - Campinas (former Brazilian Synchrotron laboratory), Habilitated (Privatdozent, livre docente) in 2013 at Universidade São Paulo. Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: cancer, onco-proteins, signaling, protein-protein interactions and cancer signaling. Published 100 papers. Tutored 24 PhD and 6 master students. Co-supervised 4 PhD and supervised 14 post-docs and 23 undergraduate students in the past. In the moment tutors 6 PhD students, 1 masterstudent, 2 undergraduate student and supervises 2 post-docs. Currently is a full professor at the school of Pharmacy UNICAMP, Brasil. Studies: signaling, Nek cinases, onco-proteins, cancer, tranformation, DDR response, DNA repair, mitochondrial metabolism and morfology. (Source: Lattes Curriculum)
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Members of the family of NEK kinases (NIMA related kinases) were identified as important regulators of cell cycle checkpoints, especially at the G2 to M phase transition. Although they are among all kinases one of the least studied families, recent studies showed they can have crucial roles in mitosis, centrosome disjunction, and in the signaling of the DNA damage response. These characte…
Ki-1/57 was discovered through the cross-reactivity of the monoclonal antibody Ki-1, the first antibody which specifically detects the cells of the Hodgkin lymphome. Preliminary studies on this protein revealed several characteristics that are common to onco-proteins. Yeast-two hybrid experiments identified interacting proteins involved in the control of transcription and RNA metabolism.…
The proteín UNC-76 was identified as an essential component for axon fasciculation and elongation in the worm Caenorhabditis elegans. In the same way, the orthologue from mammalians FEZ1 presents expression in neuronal tissues and knockout mice for the FEZ1 gene present comportamental disorders which reflect light neurological defects. In previous work our group has shown that FEZq is a m…
Normal cells generate high amounts of ATP by metabolizing glucose completely to carbon dioxide. In contrast, rapidly growing cancer cells restrict this metabolic pathway and profit from intermediate products for the biosynthesis of cell components and to influence the microenvironment. The lower molar ATP yield is compensated by increased glucose consumption. This metabolic switch is crit…
(Only some records are available in English at this moment)
Nek4 is a serine-threonine kinase from the Nek family that, among other functions, has a role in mRNA alternative splicing regulation. The mechanism of this regulation is not clear so far, but it is known that both Nek4 isoforms interact with numerous splicing factors. The alternative splicing of specific genes are frequently dysregulated in cancer, affecting cancer development and progre…
HABP4 is an unstructured protein that shows high plasticity and interaction with several targets, genes and proteins. Recent studies suggest that this protein is related to tumorigenesis, since the increase or decrease of its expression influences cell proliferation, cell cycle control and apoptosis. The Habp4 gene is located on chromosome 9, linked to four other genes, forming a haplotyp…
(Only some records are available in English at this moment)
Centrioles assemble the centrosome, the microtubule organizing centre essential for cell division in proliferating cells. Centrioles also template cilia, cell organelles that act as antenna in quiescent cells and can also generate fluid flow. Because of their essential functions in human life, centrioles are highly regulated throughout the cell cycle. Among the least studied centriole cyc…
Neks (Nima-Related Kinases) are a family of kinase proteins with important functions in cell cycle regulation, DNA damage response, and primary ciliary function. Nek4 has already been related to these three functions, but its role in these biological processes is not yet elucidated. Previous data demonstrated that Nek4 interacts with non-homologous end joining (NHEJ) proteins and that cel…
The members of NIMA related kinases (NEK) family were identified as important cell cycle checkpoint regulators, especially at G2 to M transition. Despite been one of the less studied kinase families, recent data showed that they might have crucial role in mitosis, centriole separation and signaling pathway for DNA damage. Those features together with the fact that several members of the f…
(Only some records are available in English at this moment)
NEK1 has pleiotropic functions and mutations of its gene have been reported in cancer and ciliopathies, such as polycystic kidney disease (PKD), besides some genetic diseases such as Mohr syndrome and short-rib thoracic dysplasia (SRTD). Recent studies demonstrate that loss-of-function mutations of NEK1 are related to familial ALS, however, how those mutations contribute to development of…
The eleven members of the human NEK family of serine/threonine kinases have been associated with diverse cellular processes. The function of NEK10 is poorly understood, but we have recently found that NEK10 has a role in mitochondrial morphology and function. NEK10 has several isoforms and we were able to identify at least one which is enriched in mitochondria. Immunoprecipitation followe…
Nek4 is a serine/threonine kinase that has already been implicated in primary cilia stabilization, DNA damage response, autophagy, and epithelia-mesenchymal transition. The role of Nek4 in cancer cell survival and chemotherapy resistance has also been shown. However, the precise mechanisms by which Nek4 operates remain to be elucidated. Our previous results have shown that Nek4 interacts …
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 9 / 9 | Completed research grants |
| 7 / 7 | Ongoing scholarships in Brazil |
| 58 / 35 | Completed scholarships in Brazil |
| 13 / 13 | Completed scholarships abroad |
| 88 / 65 | All research grants and scholarships |
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