CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at Bacharelado em Quimica from Departamento de Química (1994), master's at Biologia Molecular from Universidade Federal de São Paulo (1998) and doctorate at Biochemistry from Universidade Federal de São Paulo (2002). Has experience in Biochemistry, focusing on Enzymology, acting on the following subjects: specificity, thimet oligopeptidase, circular dicroism, fluorogenic substrates and fluorogenic quenched peptides. (Source: Lattes Curriculum)
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For both Zika and Dengue viruses the NS2/NS3 protease, which is formed during replication process into the host cell, is essential for the processing of the viral polyprotein. The inhibition of this enzyme blocks the replication of the virus in the host cell. Therefore, inhibitors for these proteases are potential antiviral drugs.The main objective of this project is the development of in…
Prolyl oligopeptidase (POP; EC 3.4.21.26) is a serine-peptidase present in various types of cells and tissues. Some studies have shown that POP is highly expressed in GABAergic and cholinergic interneurons from the thalamus and cortex. A distinguish feature of POP is its determined substrate specificity: POP hydrolyses peptide bonds after proline residues and only in oligopeptides with le…
In the last 4 years we have focused our research in site-specific incorporation techniques of non-natural amino acids in proteins. For this purpose two main methodologies have been developed: -the first one is the introduction of tryptophan analogs (5-fluor-Trp, 5-hidroxi-Trp, 7-aza-Trp, 5-bromo-Trp and 5-nitro-Trp) in the place of the Trp residues, by using E. coli strains compatible wit…
(Only some records are available in English at this moment)
Prolyl Oligopeptidase (POP; EC3.4.21.26) is a serine peptidase present in various tissues and cell types. Some studies show that it is highly expressed in GABAergic and cholinergic interneurons of the thalamus and cortex. A distinguishable POP feature is the cleavage after proline residues in oligopeptides smaller than 3kDa. Recent studies have indicated that the major POP action is on in…
The main goal of the present project is to study the hinge movement that the peptidase, timet oligopeptidase (TOP) may undergo upon substrate or inhibitor binding. Fluorescence techniques will be used to study this conformational change in great detail. TOP constructs will be prepared equipped with two donor-donor fluorescent probes (Trp residues) or donor-acceptor probes (5-F Trp - p-nit…
Nitrosylation is currently considered an important reversible post-translational modification of Proteins. The dynamic of enzyme nitrosylation/denitrosylation is important because occurs in a time order below milliseconds, contrasting with that of enzyme catalysis (seconds). Furthermore, some enzymes acts as pivotal regulators of NO-dependent signal transduction pathways. The overall obje…
The main goal of the present project is to study the hinge movement that the peptidase, timet oligopeptidase (TOP) may undergo upon substrate or inhibitor binding. Fluorescence techniques will be used to study this conformational change in great detail. TOP constructs will be prepared equipped with two donor-donor fluorescent probes (Trp residues) or donor-acceptor probes (5-F Trp - p-nit…
| 1 / 1 | Ongoing research grants |
| 6 / 4 | Completed research grants |
| 10 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 18 / 9 | All research grants and scholarships |
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