Graduation in Biological Sciences at the Universidade Federal de São Carlos (1992) and PhD in Biochemistry at Universidade Federal de São Paulo / University of Copenhagen, Denmark (1998). Has experience in Molecular Pharmacology, acting on the following subjects: GPCRs, Angiotensina II, 7TM receptors, mutagenesis, signal transduction, and drug discovery and development. (Source: Lattes Curriculum)
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The following activities are planned for JGB mission in Brazil in 2016:1) Discussions with CMC-N, students and post-doctoral trainees about the experimental guidelines and initial results of the Project; 2) Seminar presentation by JGB; 3) Organization of a Workshop about GPCR biased signalling. Based on the results obtained with this initial project, we plan for the end of 2016 to write a…
G protein-coupled receptors (GPCRs) constitute the largest family of signal transducer proteins in mammals and are considered a major target for drug discovery. After stimulation, GPCRs activate G proteins and then recruit β- arrestins, which more recently has been shown to lead to G protein-independent signaling that can persist even in the internalized endosomes. Recent advances in GPCR…
(Only some records are available in English at this moment)
G-protein coupled receptors (GPCRs) are integral membrane proteins characterized as having seven transmembrane alpha-helices. These receptors are important targets for biomedical studies, and approximately 40% of the currently marketed drugs act on them. The angiotensin II type 1 (AT1) receptor is a GPCR, and the main receptor of the renin-angiotensin system (SRA), mediating important pa…
G-protein coupled receptors (GPCRs) are important pharmacological targets in all clinical areas, for controlling many physiological processes. Currently, around 50% of drugs on the market act directly or indirectly through GPCRs. Large pharmaceutical companies are looking for new ligands targeting these receptors that show potential as new medicines. Recently the literature has highlighte…
G-protein-coupled receptors (GPCRs) belong to a superfamily of integral membrane proteins which have in their structure seven transmembrane alpha-helices, and for that reason, they are also known as 7 transmembrane receptors (7TMRs). 7TMRs constitute the largest class of cell surface receptors and they regulate a wide range of physiological and pathological processes, because of that, 7TM…
(Only some records are available in English at this moment)
G protein-coupled receptors (GPCRs) are integral membrane proteins characterized by a topology of seven transmembrane ±-helices that mediate a large number of physiological processes after binding of a wide range of ligands. It has been shown that during signal transduction, dynamic changes can occur in the localization of receptor and effectors in plasma membrane microdomains and intrace…
G protein-coupled receptors (GPCRs) are physiologically important cell-surface proteins that sense signaling messengers such as hormones, photons and even mechanical stress, and are the targets of several prescribed drugs. An important therapeutic target in hypertension and congestive heart failure is the renin-angiotensin system (RAS). Angiotensin II (AngII), the main component of the RA…
G protein-coupled receptors (GPCRs) constitute the largest family of signal transducer proteins in mammals and are considered a major target for drug discovery. After stimulation, GPCRs activate G proteins and then recruit ²-arrestins, which lead to disruption of G protein signaling and initiation of the internalization process. Although b-arrestin was first discovered for its role in int…
| 12 / 7 | Completed research grants |
| 18 / 8 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 33 / 18 | All research grants and scholarships |
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CV Lattes
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