After graduating at the Piracicaba Dental School, University of Campinas (FOP-UNICAMP) in 1994, I received my master (1996) and PhD (1999) in Oral Biology and Pathology from the same institution. I became an associated professor in 2006 and currently I am professor in Pathology of the Department of Oral Diagnosis, FOP-UNICAMP. I spent one year as research fellow (sandwich fellowship) in the University of Maryland Dental School (1998-1999), where I have conducted a series of experiments to understand the cellular and molecular events related to the gingival overgrowth in hereditary gingival fibromatosis, and other two years (postdoctoral fellow) working with Professor Heide L. Ford in the School of Medicine, University of Colorado Denver (2002-2004), exploring the involvement of the SIX1 homeobox gene in the development and tumorigenesis of the mammary glands. In 2022, the Faculty of Medicine of the University of Helsinki awarded me with the title of Doctor Honoris Causa from for my international contribution on oral cancer. I am Specialty Chief Editor of section Oral Cancer in Frontiers in Oral Health, associate editor of Journal of Oral Pathology and Medicine, and reviewing editorial board member of the Medicina Oral, Patologia Oral y Cirugia Bucal, Dentistry Journal, and Journal of Clinical and Experimental Dentistry. At FOP-UNICAMP, I was head of the Department of Oral Diagnosis, coordinator of the Graduate Program in Estomatopatologia, and vice coordinator of the Graduate Programs. I am currently member of the Internal Commission of Biosafety in Genetically Modified Organisms (CIBio-FOP) and PI of the molecular biology laboratory of FOP-UNICAMP. Member of the Area Panel in Health Sciences (Dentistry) at FAPESP. (Source: Lattes Curriculum)
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During oral carcinogenesis, the neoplastic cells acquire an aggressive phenotype, resulting in an increase in motility, in the ability to invade surrounding tissues and to metastasize. Metastatic spread of solid tumors is often initiated by the reactivation of an important embryonic developmental program, the Epithelial-Mesenchymal Transition (EMT). EMT has been associated with the acquis…
The aim of this proposal is to receive the Professor Tuula, University of Oulu and University of Helsinki, both in Finland, as Visiting Researcher in the Faculdade de Odontologia de Piracicaba-UNICAMP, with the objective of consolidating our collaboration in the field of aggressiveness and prognostic markers for oral cancer. Oral cancer, represented in more than 90% of cases by oral squam…
Despite the improvement in the diagnosis and treatment of patients with oral squamous cell carcinoma (OSCC), the 5-year survival rate remains around 50-60%, without significant changes in the last decades. The treatment decision and patient's prognosis relies on clinical parameters (TNM system) and histopathological features, tools that have not been shown to be widely effective. In that …
Oral squamous cell carcinoma (OSCC) prognosis is related to clinical stage and histological grade. However, this stratification needs to be refined. We conducted a comparative proteome study in microdissected samples from normal oral mucosa and OSCC to identify biomarkers for malignancy. Fascin and plectin were identified as differently expressed and both are implicated in several maligna…
(Only some records are available in English at this moment)
The lack of consistent biomarkers for oral squamous cell carcinoma (OSCC) represents a major obstacle to individualizing treatment. Recently, interleukin 17F (IL-17F) has been implicated in the development of cancers in different organs. In OSCC, IL-17F levels were associated with a better prognosis and demonstrated predominantly antitumor effects, however, an association with disease pro…
The patients affected by non-syndromic cleft lip with or without cleft palate (NSCL±P)have a higher incidence of tooth agenesis, which increases the aesthetic and functional complications, requiring more complex rehabilitation plans. Evidence suggests a connectionbetween tooth agenesis and NSCL±P due to shared genes and signaling pathways related to tooth and lip/palate development. One o…
During Oral Carcinogenesis, neoplastic cells acquire an aggressive phenotype, resulting in an increase in motility, ability to invade surrounding tissues and to metastasize. The acquisition of this aggressive phenotype, which is associated with the Epithelial-Mesenchymal Transition (EMT) process, is dependent on genetic and epigenetic modifications and on the interactions of tumor cells w…
The orofacial cleft is the most common malformation in the face, with a prevalence between 0.36 and 1.54 per 1,000 live births in the Brazilian population. With a multifactorial etiology, nonsyndromic orofacial clefts are caused by interactions between environmental factors, such as smoking and medications, and genetic factors, with one of the most studied genes being the interferon regul…
The Oral Squamous Cell Carcinoma (OSCC), the main subtype of cancer in the oral cavity, is characterized by a poor prognosis, resulting from a very aggressive local growth and high rates of locoregional recurrence. The treatment of choice for OCCs is surgery, with radiotherapy and/or chemotherapy being applied as adjuvants. Cisplatin is the most used chemotherapeutic drug for the treatmen…
Even in early clinical stages, a considerable fraction of the oral squamous cell carcinomas (OSCC) may present an aggressive behavior, with an increased tendency for local invasion, regional metastasis and recurrence after treatment. However, there are no parameters to differentiate patients that may present these tumors with a more aggressive behavior, who would benefit from a specific t…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 16 / 13 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 20 / 11 | Completed scholarships in Brazil |
| 40 / 28 | All research grants and scholarships |
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CV Lattes
ORCID