Maria Luiza de Morais Barreto de Chaves in research grants and scholarships supported by FAPESP.
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Cardiovascular diseases remain the leading cause of global morbidity and mortality today. Even considering the scientific and technological advances of the last two decades, it is estimated that in 2030 more than 23 million people will die due to cardiovascular diseases. Although different stimuli may induce heart failure (HF), it is preceded by cardiac hypertrophy, characterized by incre…
Thyroid Hormones (TH) exert numerous effects in the cardiovascular system.In this way, the hyperthyroidism is associated to elevated cardiac function and morphologic alterations in the heart as cardiac hypertrophy. We have described that the increase of cardiac mass induced by TH is mediated, at least in part by activation of Renin-Angiotensin System, mainly by AT1 Receptor (AT1R). This r…
Elevated levels of Thyroid Hormones promote a series of cardiovascular changes including cardiac hypertrophy, which may be assessed directly by in vitro or in vivo approaches. We and other authors have evidenced in diverse studies a close relationship between the cardiac effects of Thyroid Hormones and Renin-Angiotensin System (RAS) activation. However, some molecular mechanisms involving…
Several endocrine systems, such as the renin-angiotensin system (RAS) and thyroid hormones (TH) alter the cardiac function, directly or indirectly modulating the heart trophism and protecting against cardiac stress. Besides their regulatory role under situations of cardiac damage, the endocrine systems are able to interact in many of their actions. The TH promote a phenotype of cardioprot…
(Only some records are available in English at this moment)
According to Worlds Health Organization, cardiovascular diseases are the main cause of death worldwide, as it reinforces the importance of studies that lead to a greater understanding of the mechanisms by which these diseases are installed and developed. Among them, there Heart Failure (HF), an epidemic disease with high rates of morbidity and mortality. HF is commonly preceded by cardiac…
We have previously demonstrated that T3 induces to increased S100A8 levels, a DAMP involved with TLR4/MyD88/NF-kB signaling and important to cardiac hypertrophy observed in hyperthyroidism. This signaling pathway is critical to activation of intracellular sensors as NLRP3, AIM2, NLRC4 and inlammasome activation. On the other hand, beta-adrenergic stimulation also acts in the NF-kB signali…
Given that cardiovascular diseases represent the first cause of morbidity and mortality in humans, the importance and relevance of new studies is highlighted. In this context, understanding the molecular mechanisms involved in cardiac hypertrophy has been of great interest, since cardiac hypertrophy precedes almost all forms of heart failure. In addition, cardiac hypertrophy is an indepen…
Thyroid hormones (TH) are of great importance for the regulation of several mechanisms of the human organism, the heart being the main target of action of these hormones. In this sense, thyroid dysfunction has a profound impact on thecardiovascular system. Hypothyroidism, a condition where HT production is reduced, causes several cardiac morpho-functional alterations, which may be associa…
The heart is subject to numerous pathophysiological stimuli, which can lead to the development of cardiovascular diseases. Aging is one of the risk factors for these diseases, with the activation of inflammatory cascades and protein complexes called inflammasomes, in addition to the synthesis and release of cytokines. Furthermore, there is the production of reactive oxygen species and act…
(Only some records are available in English at this moment)
Clinicals and experimental studies have shown that macrophages are critical in preserve cardiac homeostasis, as well as in the response to pathological processes as occur in myocardial infarction. However, insufficient information is available about the role of macrophages in other cardiac insults, especially in non-ischemic heart disease. Recently, our research group observed a significa…
Although most of effects of nuclear factor kappaB (NF-kB) is related to inflammatoryresponse, this nuclear factor has been shown to be involved in the development ofcardiac hypertrophy resulted by diverse stimuli. In the present study, we willinvestigate whether the thyroid hormone (TH) action leading to cardiac hypertrophy ismediated by NF-kB. Transgenic mice that contain specific mut…
The heart corresponds to main target of TH and many of the classic signs and symptoms of hyperthyroidism are the cardiac and hemodynamic manifestations which include heart rhythm disorders. The present study has as aim to define the role of Caveolin-1 (Cav-1) depletion and oxidative stress in the pro-arrhythmic effects of hyperthyroidism. We will define whether Cav-1 deletion in mice lead…
| 1 / 1 | Ongoing research grants |
| 12 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 39 / 21 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 58 / 34 | All research grants and scholarships |
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