CV Lattes
Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Farmacia e Bioquimica from Universidade de São Paulo (1974), master's at Biochemistry from Universidade Federal de São Paulo (1977) and doctorate at Biochemistry from Universidade Federal de São Paulo (1988). Has experience in Biochemistry, focusing on Enzymology, acting on the following subjects: angiotensin i-converting enzyme, estudo de especificidade, fluorescent-quenched peptides, enzima conversora da angiotensina i and cathepsin x. (Source: Lattes Curriculum)
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Our proposal is to study peptidases involved in different biological systems and performing very diversified functions. Thus, in this project, we will continue the study of the participation of Plasmodium proteases in the pathophysiology of malaria, expanding the results obtained in the previous project (FAPESP 2015-11861-2). Also in this line, we will seek inhibitors of the different cla…
The purpose of this project is to use the experience of our group, gained in over 20 years of work with proteolytic enzymes, to characterize proteases of Plasmodium and theirs involvement in the pathophysiology of malaria. Analysis of the P. falciparum genome has allowed the identification of approximately 90 proteases that are involved in numerous processes, including degradation of hemo…
Studies on the structure and mechanisms of action of bioactive peptides and peptidases in experimental models of infectious diseases and cancer. All subprojects depend on an active sector of synthesis and analysis of peptides as installed at the Biophysics Department of UNIFESP. Peptides and peptidases are so broadly involved in the functioning of cells and multicellular organisms that vi…
(Only some records are available in English at this moment)
Huanglongbing (HLB) is one of the major diseases of citrus, which is caused by the Gram-negative bacteria of the genus Candidatus Liberibacter The main symptoms of HLB in plants are the yellowing of the branches, chlorosis of the leaves and damages to the fruits, which become asymmetric, small, with aborted seeds and bitter taste. In Asia and the Americas, the spread of the disease occur…
In 2015, the World Health Organization reported 214 million cases of malaria distributed worldwide, with approximately 438,000 deaths. During its life cycle, the malaria parasite invades vertebrate host erythrocytes , where a single parasite reproduces asexually producing 16 to 32 for parasites. The high rate of intra-erythrocytic proliferation is dependent on the uptake of a series of…
Brazil is one of the largest producers and exporters of oranges in the world, with the State of São Paulo the largest citrus producer in the country. However, in recent years the citrus genus plants have been strongly affected by various diseases and among these, the HLB disease (HLB) have been highlighted by severely compromising the development of plants, causing losses in fruit product…
Malaria is a serious public health problem that has severe socio-economical consequences, since the disease and poverty are strictly correlated. According to the World Health Organization, 30% of the world population lives in endemic areas of the disease. The etiologic agent of malaria is a protozoan of the genus Plasmodium and its life cycle involves a vertebrate and an invertebrate host…
(Only some records are available in English at this moment)
| 9 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 9 / 8 | Completed scholarships in Brazil |
| 20 / 15 | All research grants and scholarships |
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