CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Dr. Helder Nakaya is an expert in computational systems biology, an emerging field that combines machine learning algorithms and omics data to understand and predict the behavior of human diseases. Dr. Nakaya was a professor at the University of São Paulo and deputy director of School of Pharmaceutical Sciences until 2021, when he became a senior researcher at the Hospital Israelita Albert Einstein in São Paulo. He is also an adjunct professor of the Department of Pathology at Emory University School of Medicine in US. Dr. Nakaya is an affiliate member of the Brazilian Academy of Sciences, principal investigator at the Center for Research in Inflammatory Diseases and at the Scientific Platform Pasteur-USP, consultant for CEPI (Coalition for Epidemic Preparedness Innovations) and IUIS (International Union of Immunological Societies), as well as member of the scientific advisory board of the European Ebola Vaccine Consortium and the International Institute of Applied Systems Analysis (IIASA). Laboratory website: https://www.csbiology.org/ (Source: Lattes Curriculum)
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Classical Swine Fever (CSF) is a contagious, hemorrhagic and often fatal disease of Suidae, such as pigs and wild boar, caused by the classical swine fever virus (CSFV). CSFV is an enveloped, single-stranded RNA virus that belongs to the Flaviviridae family (Moennig, 2000), distantly related for example to Zika and Yellow Fever virus. CSFV can be controlled by vaccination particularly usi…
Data related to human health, from clinical and epidemiological information to medical images and omics data, are being generated and accumulated in an unprecedented amount in history. The analysis and integration of such information is critical to improve our understanding of the pathophysiology of diseases, their transmission, as well as their diagnosis and treatment. This project propo…
The importance of statistics in natural sciences is unquestionable. Statistics is essential to analyze data appropriately and to reach reliable conclusions. However, little is known about formal statistical methods on graphs and their theoretical properties even with an increasing number of reports on the analysis of real world networks (e.g. functional brain networks, protein-protein int…
(Only some records are available in English at this moment)
This project will foster an independently funded collaboration between laboratories of Dr. Thushan de Silva and Dr. Beate Kampmann at Imperial College London and Dr. Helder Nakaya's group (FCF-USP) at USP. By applying a cutting edge systems biology approach to integrate nasopharyngeal microbiome, mucosal and blood transcriptome, immunological and clinical data, we will identify and invest…
Infectious diseases caused by enteric pathogens are endemic specifically in developing countries, and are responsible for several thousands of deaths every year. This proposal will focus on enteric fever caused by Salmonella Typhi and Paratyphi as a model for intestinal infections. Typhoid fever significantly affects South America, sub-Saharan Africa and South-East Asia with approximately…
It is estimated that thousands of long non-coding RNAs (IncRNAs) are transcribed in the genome of several organisms. Dr. Kouzarides' group at Cambridge University re-analyzed a vast amount of RNA-sequencing data, and identified -600 IncRNAs that were "positionally conserved" (pcRNAs) in human and mo use genomes. Among the genes associated with these pcRNAs, a striking enrichment was obser…
(Only some records are available in English at this moment)
In recent years the importance of studying the communities of microorganisms present in the human intestine has been widely elucidated. These microbial communities not only contribute to the hosts local defense against infections, but theyalso modulate immune system responses in different sites and tissues. The human microbiome is dynamic, and under conditions that compromise the host def…
The present work plan aims to extract phenotypic features of the parasite species Trypanosoma, Plasmodium and Leishmania in images derived from microscopy. Such features consist of curvature attributes (minimum, maximum, average, standard deviation, variance, entropy and potential energy), geometric (area, circularity, proportion, perimeter, maximum and minimum distances); and texture sta…
The Human Cell Atlas is an international effort aiming at characterizing every cell type of the human body. Employing techniques such as single-cell RNA sequencing, mass cytometry, and multiplexed in situ hybridization, it will produce data from virtually all human tissues. This wealth of data can have a significant impact on biomedical research, but only if its content is genuinely avail…
(Only some records are available in English at this moment)
Inflammatory diseases (e.g. infectious, autoimmune and related to the cardiovascular system) constitute a complex and heterogeneous group of diseases that include a wide range of disorders and conditions characterized by inflammation. Currently, the treatments available for these diseases are limited and sometimes ineffective, requiring a deep understanding of the mechanisms involved in t…
Neurodegenerative disorders and peripheral infections generate a heavy burden onhuman health both in Brazil and worldwide. With the rise of microbial drug-resistance and life expectancy this situation is expected to be further complicated. Furthermore, the incidence of cases of infection and neurodegeneration in the same patients may also increase. It is known that alterations in peripher…
Zika virus (ZIKV) is an arbovirus that has gained high relevance in recent years. Outbreaks of infection began to become prevalent globally from the year 2007, with an epidemic in Micronesia. Since then, five of the seven continents have been affected. Infected individuals commonly present symptoms similar to those of other arboviruses, such as dengue. However, Zika infection can affect f…
(Only some records are available in English at this moment)
Metabolic Syndrome (MS) comprises a broad range of diseases in which immunometabolism and inflammation have a great influence. The increasing prevalence of obesity and MS has lead researchers investigate their influence in chronic inflammatory diseases. Despite this, little is known about the molecular pathways and gene networks that are in common between MS and inflammatory diseases. To …
| 4 / 4 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 7 / 7 | Ongoing scholarships in Brazil |
| 10 / 10 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 26 / 26 | All research grants and scholarships |
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