Postdoctoral studies in Molecular and Cellular Physiology at Stanford University, CA, USA (1999-2001) and in Exercise Physiology at the Norwegian University of Science and Technology, Trondheim, Norway (2009). Sabbatical leave and guest professor at the Norwegian University of Science and Technology, Trondheim, Norway (2012-2013). Currently is Full Professor at the Dept of Physiology and Biophysics- Biomedical Sciences Institute and at the School of Physical Education and Sport - University of Sao Paulo. Member of the Area Panel in Health Sciences at São Paulo Research Foundation (FAPESP). Member of the Brazilian Academy of Sciences. She has experience in Exercise Physiology with emphasis on cardiovascular adaptations to exercise training. Her research is focused on the following topics: a) effect of exercise training in heart failure and cancer with a focus on molecular mechanisms involved in controlling the function and remodeling of the heart muscle b) molecular mechanisms involved in skeletal myopathy of heart failure and cancer with emphasis on the control of skeletal and trophism effect of aerobic exercise training. (Source: Lattes Curriculum)
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Most cancer patients, under active treatment or not, are sedentary, despite increasing scientific and clinical understanding of the benefits that exercise and physical activity can have, such as improving quality of life, limiting disease symptoms, decreasing cancer recurrence, and increasing overall survival. Studies have shown that both supervised exercise and unsupervised physical acti…
With the increase in the life expectancy of the population it is estimated that millions of new cases of chronic diseases, such as cancer and heart failure, will be diagnosed in the coming years. Advances in the treatments have significantly improved the survival of patients; however, associated factors such as skeletal muscle mass loss and dysfunction (named cachexia) affect not only pat…
(Only some records are available in English at this moment)
Due to advances in research and antineoplastic treatment, the survival of women with breast cancer has increased significantly. However, side effects associated with chemotherapy have affected their quality of life and health. Among these side effects, autonomic dysfunction, characterized by sympathetic hyperactivity and vagal hypoactivity, has emerged for its association with a higher su…
Cancer encompasses a group of diseases originating from genetic mutations within cells, leading to uncontrolled cell division and the ability to invade surrounding tissues. According to the Global Cancer Observatory, colon cancer ranks as the third most incident type of cancer worldwide. In Brazil, it stands as the third most fatal cancer. While conventional pharmacological treatments rem…
Studies over the last two decades have shown that chronic stress, through the activation of beta-adrenergic receptors by effector molecules of the Sympathetic Nervous System, plays an important role in the development and progression of cancer; however, the molecular bases underlying these effects require further investigation. On the other hand, it is known that sirtuins, a family of his…
(Only some records are available in English at this moment)
Cancer cachexia is a multifactorial syndrome characterized by loss of muscle mass, a condition that negatively affects the prognosis and quality of life of patients. Skeletal muscle depletion during cancer is related to shorter survival and reduced physical fitness. In addition, muscle atrophy, in general, is associated with contractile dysfunction, both being directly affected by oxidati…
Pathological changes in the autonomic nervous system have been proposed as sensitizing/potentiating factors in the Cancer continuum, contributing to its development, progression and aggressiveness. In fact, increases in Sympathetic Activity (SA) accelerate tumor progression in animal models of various types of Cancer, mainly through the activation of ²2-adrenergic receptors. It is also kn…
We have as perspectives to describe the impact of QT on the composition physical fitness and to understand if the impairment in these variables regardless of response to treatment can be considered a predictor prognosis.
(Only some records are available in English at this moment)
It is already known that aerobic exercise training (AET) attenuates the process of skeletal muscle loss in experimental models of cancer cachexia, becoming an adjuvant therapy for the prevention of muscle mass loss and dysfunction. In addition, AET reduces the incidence of many cancer types, while slowing tumor growth in different cancer models. However, the molecular mechanisms involved …
Sympathetic hyperactivity (SH) is a hallmark of heart failure (HF) and several lines of evidence suggest that SH contributes to HF induced skeletal myopathy. The latter is characterized by skeletal muscle abnormalities in HF, such as impaired muscle oxidative metabolism atrophy and shift toward fast twitch fibers (type II fibers) that are also more susceptible to atrophic stimuli. Taking …
Aerobic fitness levels are one of the strongest predictors of morbidity and mortality in healthy and chronic diseases population. These benefits are mediated in part by extensive metabolic and molecular remodeling of skeletal muscle. However, the mechanisms underlying this significant association are still unresolved. In the present project, we propose to further explore this association …
Cachexia syndrome remains as a key problem for cancer patients. Importantly, the molecular basis of cancer cachexia is complex and still poorly understood. Recently, we found that high-intensity interval training (HIIT) improves exercise capacity and increases survival in a severe cancer cachexia rat model. Importantly, HIIT fully restored skeletal muscle function and redox balance to the…
(Only some records are available in English at this moment)
| 15 / 12 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 39 / 21 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 5 / 4 | Completed scholarships abroad |
| 65 / 43 | All research grants and scholarships |
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CV Lattes
ORCID