Undergraduate in Biology from Universidade Federal do Rio de Janeiro (1990), master's from Instituto de Biofísica Carlos Chagas Filho (1992), M.Sci , M. Phil and Ph.D from Neurobiology and Behaviour from Columbia University (1998) and Postdoctoral training at Rockefeller University (2001). She is now an associate professor and Principal Investigator in the Laboratory of Vertebrate Embryology, at the Department of Cell and Developmental Biology, USP (Brazil). The laboratory research focus on optic morphogenesis and neural differentiation in the chick embryo. (Source: Lattes Curriculum)
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The neural differentiation of the central and peripheral nervous system depends on the evolution of the transcriptome. Transcriptomic changes in neural differentiation depend on the pattern of expression of several factors. Considering the diversity of cell types generated in the nervous system, the number of neural transcription factors is limited. In other words, complexity in the trans…
In the embryo, gene expression and morphogenesis are intrinsically connected. Given the complexity of their interplay, our approach has been to explore these two aspects of embryogenesis separately. Our long term goal is to understand gene expression control in neural tube embryogenesis and cell signaling during lens placode morphogenesis. Specifically, in this project our aims are (1) t…
The complexity of the neural differentiation process has challenged our understanding of its intricacies. In light of this, the efforts to understand the neural embryogenesis contribute not only towards the field of Developmental Biology but also in the optimization of in vitro differentiation protocols for therapeutic ends. In this proposal, we will focus on the transcription factor Scr…
In ovo electroporation of the chick neural tube is a fast and inexpensive method for identification of gene function during neural development. This work describes a simple method for comparing transcriptomes from samples of transfected embryonic spinal cords comprising all steps between electroporation and identification of differentially expressed transcripts. The first stage consists o…
(Only some records are available in English at this moment)
The spinal cord, a component of the central nervous system, is composed of populations of interneurons organized in layers that receive distinct sensory information. The development and growth of the spinal cord occurs through the proliferation and differentiation of cells located in the caudal portion of the neural tube. The spinal cord subtypes of interneurons originate from progenitor …
The neural development during embryogenesis is a gradual and complex process, which requires specific sequential steps from the cease of progenitors proliferation to terminal differentiation into neuronal subtypes. The complexity of this process is exposed through a vast number of neuronal subtypes in the adult organism. By this time, very little is known about the genes involved in neuro…
The process of filopodia emission involves cytoskeleton rearrangement and it is well described in many cell types, in cell migration processes and in the embryonic epithelium movement. The decision between emission or not of filopodia is determined by various molecular pathways of actin polymerization. Among these, the CDC42-GTPase activity is an important factor on the formation of these…
The family SCRATCH of transcription factors belongs to the superfamily Snail, whose members present a carboxyl-terminal region conserved composed by from 4 to 6 zinc-fingers domains, responsible for the DNA binding on the consensus site E-box. The amino-terminal region, less conserved, contains the SNAG domain and seems to be responsible for the recruitment of transcriptional repression m…
(Only some records are available in English at this moment)
The development of the vertebrate eye requires precise positioning and reciprocal alignment of its components to achieve maximal visual performance. The anteriormost components - the lens and the cornea - derive from neighboring regions in the ectoderm that overlies the optic vesicle. As the lens placode invaginates inward to form the lens vesicle, the surrounding periplacodal cells migra…
Embryonic stem (ES) cells are characterized by the capacity to differentiate into any cell type and by their ability to self-renewal. Available methods to promote ES cell differentiation towards neural lineages attempt to replicate, in different ways, the multistep process of embryonic neural development. The steps involved in the in vitro acquisition of a neural fate are very similar to…
Our laboratory aims to dissect the molecular role of chicken Scratch2 (cScrt2) in neural development. Our past results indicate that cScrt2 acts as a transcription factor in post-mitotic neural precursors. However, in invertebrates Scrt is associated with proliferating neuroblasts as well. Thus, our aims in this proposal are twofold: (1) identify direct transcriptional targets of cScrt2 a…
| 1 / 1 | Ongoing research grants |
| 10 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 14 / 7 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 29 / 17 | All research grants and scholarships |
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