bachelor's at Odontologia from Universidade Camilo Castelo Branco (1991), master's at Experimental Oral Pathology from University of London (1996) and doctorate at Odontology from Universidade de São Paulo (2000). Has experience in Odontology, acting on the following subjects: desenvolvimento, integrinas, glândulas salivares humanas, oral and integrins. The main research subject is on pathological processes of salivary gland degeneration. (Source: Lattes Curriculum)
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Sjögren's syndrome (SS) is a chronic autoimmune disorder characterized by dysfunction of the exocrine glands, including salivary and lacrymal glands. SS immunopathology results from the interplay between immune and epithelial cells; the latter play an important pathogenic role in SS as suggested by the presence of infiltrating lesions (epithelitis) as well as the increased epithelial expr…
Lupus erythematosus (LE) is an autoimmune disease that affects multiple organs. It may affect the oral cavity and around 75% of the patients report subjective sensation of dry mouth (xerostomia). Our research group has demonstrated in multiple studies that xerostomia in LE is related to a type of manifestation specific of the disease - the lupus sialadenitis - which includes morphological…
Xerostomia is characterised as a subjective dry mouth feeling which can be a consequence of reducing or interrupting salivary gland function. This condition composes a complex exocrinopathy responsible for damaging salivary glands in Sjogren's syndrome (SS) and also in Lupus Erythematosus (LE). The pathogeny of xerostomia in both diseases remains unclear. For two years, our group performe…
The graft-versus-host disease (GVHD) is a complication that occurs after allogeneic bone marrow transplantation, T-cell mediated graft attacking the cells and tissues of the recipient, including the oral mucosa and salivary glands in a inflammatory process, and may trigger a restriction of mouth opening. Cytokines, such as interleukin 18 (IL-18) are involved in the activation of cytotoxic…
(Only some records are available in English at this moment)
The salivary glands are responsible for the synthesis and secretion of saliva, an important lubricant fluid in the oral cavity. However, pathophysiological alterations may influence the salivary glands' function, affecting the oral health, with clinical manifestations such as xerostomia, the subjective sensation of dry mouth. The salivary fluid synthesis is dependent upon multiple process…
Lupus erythematosus (LE) is an autoimmune disease that affects multiple organs. It can affect the oral mucosa and around 75% of the patients report subjective sensation of dry mouth (xerostomia). Our research group has demonstrated in multiple studies that xerostomia in LE is related to a type of manifestation specific of the disease - the lupus sialadenitis - which includes morphological…
Primary Sjögren's syndrome (SSp) is an autoimmune inflammatory disease of slow progression affecting the exocrine salivary and lacrimal glands. Its main manifestation is the sicca syndrome, which is characterized by the decrease of the salivary and lacrimal secretions leading to the symptoms of xerophthalmia and xerostomia. The disease affects 0.5% of the world population, being more prev…
Squamous cell carcinoma (SCC) is the most common neoplasm of the oral cavity, and the tongue is the most affected structure. The lesions present various degrees of differentiation and metastatic dissemination, with worst prognostic as less differentiated and more disseminated, with several esthetic and functional damages to the patient. Many mechanisms of SCC development are unclear. Cyto…
(Only some records are available in English at this moment)
To date it is well known that the presence of autonomic nerves is required for proper development of salivary glands. In particular, it has been extensively reported that the parasympathetic nerves have an essential role during mouse gland development, maintaining the epithelial progenitor cells in an undifferentiated state. The role of the sympathetic nerves in turn has been correlated t…
Salivary glands secrete saliva, which is essential to the maintenance of oral health. Permanent salivary gland dysfunction mostly caused by radiotherapy, inflammatory diseases and congenital syndromes, frequently affects physiological oral functions, such as speech, taste and mastication, while also increases the risk of caries and oral mucosa injuries. The current treatments available ar…
Salivary glands (SG) comprise the main tissue responsible of secreting saliva in the oral cavity. The reduction or even the lack of saliva is the most common reason that leads to the subjective feeling of dry mouth known as xerostomia. In general, the consequences of xerostomia affect oral physiological functions as speech, taste, mastication, and more importantly increases the risk of in…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 11 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 17 / 10 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 36 / 23 | All research grants and scholarships |
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CV Lattes
ORCID