Sandra Helena Poliselli Farsky was under graduated in Pharmaceutical Sciences by the University of São Paulo (1986); Ph.D. in Pharmacology (1994) by the Institute of Biomedical Sciences, University of São Paulo; and Associated Professor (2006) and Full Professor (2011) in Toxicology by the Faculty of Pharmaceutical Sciences, University of São Paulo. Since 2011 she has been Head of the Department of Clinical and Toxicological Analysis of the Faculty of Pharmaceutical Sciences, University of São Paulo. She investigates the endogenous control of leukocyte migration from reservoir compartments to blood and to inflammatory focus and the actions of xenobiotics on the immune host defence. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Casi un millón de brasileños fuman cigarrillos electrónicos regularmente |
| Almost one million Brazilians regularly use e-cigarettes |
| News published in Agência FAPESP Newsletter about the researcher |
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The incidence of Rheumatoid Arthritis (RA) is increasing worldwide, which leads to public health concerns, as the disease causes chronic and severe morbidity, there are no effective treatments, and existing ones, such as biological drugs, are high cost. The genesis of RA has a genetic and environmental basis, and in this last context, exposure to tobacco stands out. Because of the recogni…
The flow cytometer is a device that separates the cells by size and granulosity, marking membrane, cytoplasmic and nuclear proteins, using specific fluorophores. In the present project, the flow cytometry will be used for quantification of cell death and oxidative stress, expression of adhesion molecules, Annexin A1, TSPO, besides the secretion of cytokines by the use of CBAs kits. For …
Inflammation is a primordial, complex and highly evolutionary-conserved active response mounted by the innate immune system in response to injury, xenobiotics exposure and infections in order to promote recovery. In addition, inflamamtion is relevant to some special conditions of the body, such as to the succesfull of gestation, and on obesity. Control of the inflammatory response is of …
(Only some records are available in English at this moment)
Smoking is related to the pathogenesis of multiple sclerosis (MS), a demyelinating neurodegenerative autoimmune disease, mediated by T lymphocytes; However, the participation of tobacco and nicotine combustion components in its genesis is controversial. Non-combustible cigarettes (heat-not-burn tobacco; HNBT) have emerged as less toxic alternatives to conventional cigarettes (CC) for rele…
Annexin A1 (AnxA1) is a 37 KDa protein secreted by several cells with inflammatory response modulating role. AnxA1, an important anti-inflammatory protein, modulates experimental colitis and our research group has shown that AnxA1 mediates the treatment of the disease with infliximab. Lipid core nanocapsules (LNCs) carry molecules of different natures, including biological products, and h…
Smoking is the most important cause of morbidity and mortality in the world. In this context, smoking is the more relevant environmental factor involved in the genesis of articular diseases, such as Rheumatoid Arthritis (RA) and Osteoarthritis (OA), but the mechanisms and cigarette compounds involved still unclear. Hydroquinone (HQ) is the most abundant pro-oxidative compound in cigarette…
Ulcerative colitis is a chronic disease that affects the lower gut and afflicts thousands of people worldwide, not only reducing overall living standards of patients but also burdening healthcare systems. Not all causes for the etiology of the disease are understood, but it is known that deregulation of the inflammatory process is essential for its progression. Inflammation is a biologica…
(Only some records are available in English at this moment)
The evolution of different types of organoids allowed a better understanding of organogenesis and also of the pathophysiology of different diseases. It is clear that the genesis and progression of Intestinal Bowel Disases (IBDs) share complex mechanisms and an intense multicellular interaction, that is often impossible to reproduce and observe them in 2D in vitro platforms. AnxA1, an endo…
Smoking is the most important cause of morbidity and mortality in the world. In this context, smoking is the more relevant environmental factor involved in the genesis of articular diseases, such as rheumatoid arthritis (RA) and osteoarthritis (OA), but the mechanisms and cigarette compounds involved still unclear. Hydroquinone (HQ) is the most abundant pro-oxidative compound in cigarette…
Inflammatory bowel diseases (IBDs) identify idiopathic and debilitating illnesses characterized by severe gastrointestinal inflammation. Tumor necrosis factor-alpha (TNF-a) is considered the main cytokine involved in the IBD pathogenesis, thus, inactivating tools addressing this pro-inflammatory cytokine have been developed, including the anti-TNF-a monoclonal antibody, infliximab (IFX). …
Crohn’s disease and ulcerative colitis are inflammatory diseases of the gastrointestinal tract which are associated to an increased risk of colon cancer. These conditions affect millions of people all over the world and are responsible for a considerable public spending in developed and developing countries, such as Brazil. The inflammatory bowel diseases, known as IBD, are chronic inflam…
| 1 / 0 | Ongoing research grants |
| 29 / 15 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 36 / 18 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 71 / 38 | All research grants and scholarships |
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