Professor of Virology, University of São Paulo School of Medicine in Ribeirão Preto (FMRP-USP). Physician (UFC/1982), with residency in internal medicine (UFC/1983), specialist in Infectious Diseases (UNIFESP/1987) and Clinical Pathology (University of Virginia/1996), Ph.D. (UNIFESP + University of Virginia School of Medicine/1991), post-doctoral fellow in Virology (University of Virginia School of Medicine (1992-1993). Research Assistant Professor of Virology, Departments of Pathology and Internal Medicine, University of Virginia School of Medicine (1993-1996). Head of the Viral Pathogenesis Laboratory, Virology Research Center, FMRP-USP. Fellow of the American Academy of Microbiology since 2014 . President of the Brazilian Society of Virology (2013-2014). Chair of the Institutional Research Committee, FMRP-USP (2016-2020). Member of the Membership Committee, American Society for Virology (2017-2019) and Membership in the American Thoracic Society since 2019. Chairman, Department of Cell and Molecular Biology, FMRP-USP since 2020. Advisor of M.Sc. and PPh.D. in the Graduate Studies Program in Cell and Molecular Biology, FMRP-USP. Research interests: Pathogenesis and persistence of respiratory viroses, inclusing SARS-CoV-2; pathogenesis of Oropouche virus; vertical transmission of human viruses; biology of leishmania viruses. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| El virus evoluciona |
| The evolution of a virus |
| Natural guests |
| Los huéspedes naturales |
| Novel coronavirus in Brazil |
| El nuevo coronavirus llegó a Brasil |
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
This thematic research project is proposed based on a central backbone of research on viruses of great importance for human health. The proposal comes from five collaborative research groups, led by established professors, and consists of subprojects distributed in four major areas of work: 1) Virus-cell interaction; 2) Pathogenesis of viral infections; 3) Diagnosis and prospection of hum…
This thematic research project is proposed based on a central backbone of research on viruses of great importance for human health. The proposal comes from five collaborative research groups, led by established professors, and consists of subprojects distributed in four major areas of work: 1) Virus-cell interaction; 2) Pathogenesis of viral infections; 3) Diagnosis and prospection of hum…
This thematic research project is proposed based on a central backbone of research on viruses of great importance for human health. The proposal comes from five collaborative research groups, led by established professors, and consists of subprojects distributed in four major areas of work: 1) Virus-cell interaction; 2) Pathogenesis of viral infections; 3) Diagnosis and prospection of hum…
Rhinovirus (VR) is the infectious agent that most frequently affects the human species, causing acute respiratory infections (ARI), and is often associated with exacerbations of asthma and chronic bronchitis / emphysema, as well as secondary complications such as sinusitis and otitis media. Studies done by our group have shown that RV often infects tonsils and is excreted in nasopharyngea…
This thematic Project includes 29 subprojects, focusing on emerging zoonotic viruses of the family Bunyaviridae, distributed in 3 genera: Orthobunyavirus, Phlebovirus and Hantavirus. The project involves 3 Principal Researchers, 55 Brazilian and international collaborators, and will take 4 years. For studies on the genus Orthobunyavirus, serological diagnosis of Oropouche virus (OROV) by …
Infections caused by human paramyxoviruses have great impact in public health, but little is known about their pathogenesis. Evidence recently produced by our group suggests that these agents frequently persist in lymphoid tissue of human tonsils. Such tonsillar persistence of paramyxoviruses is importante because of the possible pathogenic and immunologic consequences, as well as because…
(Only some records are available in English at this moment)
Respiratory viruses have a strong impact not only on public health, but also on social and economic aspects, affecting the entire world. This is clear as in the cases of pandemic respiratory viruses such as Influenza and SARS-CoV-2. The tonsils play an important role in the immune response against ingested or inhaled pathogens. Our research group showed that the tonsillar tissue can be an…
The present scientific initiation project focuses on the study of SARS-CoV-2 infection of the spleen, an important site of secondary lymphoid tissue with an important role in the assembly of the immune response. This research effort will be possible through the collaboration already existing between the Laboratory of Viral Pathogenesis of the Virology Research Center, with the Department …
Hypertrophy of adenoids and palatine tonsils is a highly prevalent chronic inflammatory condition of unknown etiology, with a strong impact on children's health, usually leading to surgery. As sentinels of the upper airways, the tonsils play important roles in the immune response to Respiratory Viruses (RVs), which are the most frequent causes of Acute Respiratory Infections (ARI). In pre…
(Only some records are available in English at this moment)
The Oropouche Arbovirus (OROV) is the causative agent of Oropouche fever, whose main urban vector is Culicoides from Pará, an endemic disease in the Amazon region and emerging in other regions of the country, with new cases being reported in the Northeast, Central-West, and Southeast. In the last 60 years, it has been responsible for more than half a million of cases in approximately 30 o…
Influenza A viruses (IAV) cause acute infections of the respiratory tract that can progress to serious conditions such as bronchiolitis and pneumonia. In humans, IAV transmission occurs via the respiratory route through droplets and aerosols expelled by carriers, followed by inhalation by recipients, or by fomite contamination followed by self-inoculation. IAV infects the respiratory epit…
(Only some records are available in English at this moment)
Influenza viruses cause more than two million annual episodes of seasonal acute respiratory infections (ARI) and approximately 500 thousand deaths worldwide. Evidence from literature indicates that, depending on virus strain and host immune status, infections by influenza A virus (IAV) may be asymptomatic and reach sites other than the respiratory tract. Our previous results indicated tha…
In summary, as part of their evolution, both viruses and host cells are capable to manipulate the miRNAome, kinases, and inflammasome activation to regulate the overall immune response in a virus and cell type specific fashion. Understanding changes in miRNA and kinase-expression profiles, identifying target genes and their contribution to the…
The Oropouche virus (OROV) is the second most frequent arboviral ilness in Brazil, with more than 0.5 million cases documented in the last 30 years. OROV occurs predominantly in the Amazon region, but has been isolated in the Southeast. The pathogenesis of OROV infection is not completely known. It was recently demonstrated that the virus induces apoptosis and that this effect requires th…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
| 16 / 11 | Completed research grants |
| 7 / 7 | Ongoing scholarships in Brazil |
| 48 / 17 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 78 / 42 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID