CV Lattes
Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor's Degree in Biological Sciences from the Universidade de São Paulo (1979); Ph.D. degree in Genetics from the University of Chicago (1984); Post-Doctoral Research in Molecular Biology at Northwestern University Medical School (1984-1986). Has experience in Molecular Biology, focusing on Protein Synthesis and Translational Regulation in eukaryotes. Professor in the Department of Microbiology/Immunology/Parasitology, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp). (Source: Lattes Curriculum)
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Dr. Sattlegger's visit to my group aims at strengthening our research regarding the function of a highly conserved protein named Yih1 in the yeast S. cerevisiae and IMPACT in mammals. Previous works from both Dr. Sattlegger's and my group have shown that Yih1/IMPACT is an inhibitor of the protein kinase, GCN2. GCN2 is activated by amino acid starvation and a variety of other stress condit…
Regulation of translation provides the cell with the plasticity needed to respond to rapid changes in the environment. Given that translation consumes more than 50% of cell's energy, it is not surprising that translation is tightly regulated. In many aberrant cellular processes, the translation machinery and translation output (ie proteome) are modified. This is often the case in various …
Translational control mediated by the phosphorylation of eukaryotic initiation factor -2 (eIF2) is important for cellular adaptation to a variety of environmental stress situtations, and its impairment results in pathological conditions in humans. One elF2 kinase, GCN2, extensively studied in the yeast model, has recently been the focus of major findings in mammalian physiology. GCN2 cont…
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The protein kinase GCN2 down-regulates protein synthesis by phosphorylating eIF2alfa in response to different cellular stresses and starvation, while simultaneously triggering the preferential translation of some mRNAs that allows cells to promote a response to maintain their homeostasis and cope with stress. The actin cytoskeleton is an essential and dynamic structure. Its disorganizatio…
Translational control mediated by the phosphorylation of initiation factor 2 (eIF2) is crucial for the adaptation of cells to different stress conditions, and malfunction of this signal pathway can lead to important pathologies. One of the four eIF2 kinases in mammals, GCN2, regulates de expression of large number of genes in response to e.g., amino acid deprivation. GCN2 also determines …
| 17 / 10 | Completed research grants |
| 24 / 2 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 42 / 12 | All research grants and scholarships |
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