graduate at Ciências Biológicas from Universidade de São Paulo (1965) and ph.d. at Biochemistry from Universidade de São Paulo (1969). Has experience in Biochemistry, acting on the following subjects: ciclo celular, hormônios e oncogenes, fatores peptídicos de crescimento, acth and fgf. (Source: Lattes Curriculum)
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Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan lnstitute historically built its strong international reputation. lndeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic…
Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan lnstitute historically built its strong international reputation. lndeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic…
Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan lnstitute historically built its strong international reputation. lndeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic…
(Only some records are available in English at this moment)
Once our lab is especialized in cellular signaling and cell cycle control, this flow cytometer will allow us to do better analyzes in both subjects. This equipment is able to: do cell cycle analyzes; mark cell signaling pathways; determine cell species, population dynamics and so on. Moreover, the equipments software permits single cell analyzes, which can be useful to design mathematical…
Structural analysis of protein complexes. (AU)
Recently we reported for the first time a dual action of FGF2 (Fibroblast Growth Factor 2) in ras-dependent malignant cells, triggering ERK-MAPK and PI3K mitogenic pathways and initiating a novel pathway mediated by FGFR-TyrKinase→RhoA-GTP, that blocks cell cycle and causes senescence. This antagonistic phenomenon sharply stands against the notion that FGF2 is oncogenic, suggesting that F…
(Only some records are available in English at this moment)
TITLE: Cell cycle control in normal and malignant cells, new approach in cancer therapy.ABSTRACTThis project is focused on experimental proof of concept of the following hypothesis: malignant cells, but not normal cells, are killed by certain combinations of a mitogen plus an inhibitor targeting a specific stress pathway. This hypothesis was first proposed in a recent paper of our laborat…
We previously reported that Kras-driven Y1 tumor cells exhibit an unlikely association of high basal levels of K-Ras-GTP with cell cycle arrest by Fibroblast Growth Factor 2 (FGF2). Furthermore, in Y1 cells, experimental ectopic expression of an inducible dominant negative mutant, Ras-N17, reduced K-Ras-GTP basal levels and rescued FGF2 mitogenic activity (Costa et al. 2008; Salotti et al…
(Only some records are available in English at this moment)
We propose that in Ras-driven malignant cells there is a functional interaction between cyclin D1 and this oncogene; in which the main function of cyclin D1 is to guarantee cell survival overcoming the Ras oncogenic stress. We showed in the presented reports that CRISPR-Cas9-mediated cyclin D1 depletion induces p53-independent senescence in Ras-driven carcinoma cells. Moreover, in MEFs cy…
| 5 / 5 | Ongoing research grants |
| 15 / 10 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 41 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 63 / 23 | All research grants and scholarships |
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CV Lattes
ORCID