Nilson Ivo Tonin Zanchin

• Abstract

  Eukaryotic ribosome biogenesis requires the function of a large number of trans-acting factors which interact transiently with the nascent pre-rRNA and dissociate as the ribosomal subunits proceed to maturation and export to the cytoplasm. Loss-of-function mutations in human trans-acting factors or ribosome components may lead to genetic syndromes. In a previous study, we have shown assoc…

  The NIP7 protein is required for accurate pre-rRNA processing in human cells, PUB.ART

• Abstract

  In eukaryotes, many posttranscriptional processing events are necessary for the synthesis of mature RNAs. mRNAs, tRNAs, rRNAs, snRNAs and snoRNAs are processed through several steps that involve specific reactions between RNA and proteins. Although most processing factors are specific for each pathway, some of those involved in the maturation of the different kinds of RNAs are common to a…

  Structural study of protein components of the exosome and some of its regulatory factors from Archaea and yeast, AP.TEM

• Abstract

  We envisage finding the structures of proteins which: I) have potential of playing a functional role in the induction and/or sustenance of malignant phenotypes in humans; II) are functionally important in plants and bacteria. For some of these proteins, attempts will be made to determine structures that may reveal new folds; III) exhibit high potential of having its structure determined b…

  A structural biology laboratory network for the study of the 3D structures of proteins, AP.GEN

• Abstract

  Living cells are constantly responding to a great variety of stimuli, which are interpreted and integrated by signaling pathways and result in a biological response - for example, differenciation, apoptosis or migration. These pathways are regulated by kinases and phosphatases. Recent large scale efforts have been made to identify and characterize kinase substrates, but phosphatase substr…

  Identification of novel TIPRL and alpha4-regulated targets of type 2A phosphatases in signaling pathways and gene expression control., BP.PD
• Analysis of the expression pattern and protein interactions of a new isoform of the catalytic subunit of the protein phosphatase 2 (PP2Ac), BP.IC

• Abstract

  Our research group is part of the Center for Structural Molecular Biotechnology (CBME), which is part of the CEPID-FAPESP program. CBME laboratory members are developing an integrated project to determine the structure and function of the 14 human septins. Initial functional assays are focusing on the identification of septin-interacting partners using the yeast two-hybrid system. By usin…

  Interaction between the human proteins SEPT3 and PM-Scl75/hRrp45: analysis of the connection between septin filaments and the exosome complex, BP.IC

(Only some records are available in English at this moment)