CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Química (IQ) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Prof. Marcelo G. de Oliveira received his Ph.D. in Science from the University of Campinas (UNICAMP) in São Paulo state, Brazil in 1992 where he was appointed Assistant Professor in 1987. After his doctoral studies, he served as Visiting Research Fellow at the Chemistry Department of the University of Southampton, UK, from 1993 to 1995. He was appointed Associate Professor in the Physical Chemistry Department of the Institute of Chemistry of UNICAMP in 2000 and Full Professor in 2014. His current research work is aimed at the preparation of polymeric biomaterials for the controlled release of nitric oxide (NO) in biomedical applications. He has authored 84 articles in peer-reviewed journals, and 14 patents filed in Brazil and other countries; several of them have been licensed to pharmaceutical companies. He is a reviewer of 33 scientific journals on chemical, medical and pharmaceutical research, has supervised 10 doctorate and 15 master theses, 25 undergraduate research trainee students and 8 Post-docs. (Source: Lattes Curriculum)
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The development of novel biomedical technologies for tissue engineering and controlled drug delivery has demanded new platforms of degradable biomaterials capable of avoiding late complications in implantable devices. In turn, non-absorbable biomaterials for topical use have demanded new developments for improving their efficacies, especially for the topical treatment of chronic wounds. I…
Nitric oxide (NO)-mediated vasodilation plays a key role in gastric mucosal defense, and NO-donor drugs may protect against diseases associated with gastric mucosal blood flow (GMBF) deficiencies. In this study, we used the ex vivo gastric chamber method and Laser Doppler Flowmetry to characterize the effects of luminal aqueous NO-donor drug S-nitroso-N-acetylcysteine (SNAC) solution admi…
Diabetes mellitus (DM) affects about 20 million of individuals in Brazil. Roughly, a third of these individuals will develop renal and retinal diseases. Although in the last decade the understanding of the pathogenesis and treatment of these conditions has advanced considerably, the number of individuals who develop end-stage renal disease and blindness secondary to diabetes is still risi…
(Only some records are available in English at this moment)
3D printing of hydrogels for biomedical applications has been the focus of growing scientific interest, due to the similarities of hydrogels with living tissues and the possibility of printing customized prostheses. The main objective of this project is to develop nitric oxide (NO) donor hydrogels coated with polydopamine (PDA) for the construction of tubular vascular prostheses by 3D pri…
The main objective of this project is the development of new F127 hydrogels functionalized with terminal S-nitrosothiol (SNO) groups. The modified F127 (F127-SNO) hydrogels are expected to retain their thermo-sensitive property, undergoing gelation with the increase in temperature and to be capable of releasing NO thermally and photochemically. The first step in this development will be t…
The aim of this project is to produce and characterize self-organized and multicomponent hybrid hydrogels that are able to locally deliver nitric oxide (NO) in a prolonged fashion. NO is one of the smallest known biologically active molecules which participates in a series of physiological and pathophysiological processes, such as epithelial tissue regeneration, vasodilation and, in incre…
The multiple physiological actions of nitric oxide (NO), including the vasodilation and the acceleration of wound healing, have motivated the development of biomaterials for local NO re-lease. Poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels are widely used for the manufacturing of contact lenses. More recently the presence of vinyl groups in the monomer has allowed the 3D printing of …
Nitric oxide (NO) acts in several physiological processes such as wound healing and vasodilation, which has stimulated the development of hydrogels capable of releasing NO locally in biomedical applications. The main objective of this project is the development of photocrosslinkable NO donor hybrid hydrogels for the 3D printing of biomaterials. The hydrogels will be synthesized from the p…
Polynitrosated polyesters may be used for the surface coating of blood-contacting medical devices, including ventricular assist devices (VAD) and intracoronary stents, in order to reduce their thrombogenicity. The objectives of the present project are: (1) the preparation of blends of polysulfhydrylated polyester (PSPE) with poly(L- lactic acid) (PLLA) and poly(caprolactone) (PCL) by spin…
(Only some records are available in English at this moment)
In this study, gelatin/polycaprolactone nanoparticles (Gelatin/PCL-NPs) nanocomposites, charged with the hydrophilic (S-nitrosoglutathione, GSNO) and hydrophobic (S-nitroso-N-acetylpenicilamime, SNAP) NO donors will be prepared with the aim of obtaining a formulation with dual NO release profile: a faster NO release provided by GSNO, which will be present in the gelatin phase, followed b…
The main aim of this project is to characterize the influence of poly(vinyl alcohol) (PVA) on the phase behavior of Pluronic F127 hydrogels by Small Angle Neutron Scattering (SANS) and Differential Scanning Calorimetry (DSC). SANS experiments will be performed at the ISIS facility, Rutherford Appleton Laboratory, UK. DSC thermograms will be obtained in a Q10 calorimeter (TA Instruments) a…
Polymers capable of releasing nitric oxide (NO) in a controlled manner are currently an important class of materials for biomedical applications. Among the hydrophilic polymers used in the biomedical field, polyvinyl alcohol ([CH2CHOH]n, PVA) offers several advantages including easy processability and excellent biocompatibility (FDA approved for clinical use in humans). Preparation of PV…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 13 / 10 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 32 / 14 | Completed scholarships in Brazil |
| 6 / 5 | Completed scholarships abroad |
| 55 / 33 | All research grants and scholarships |
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