Abstract
Abnormal activation of MAPK, via which normally regulates proliferation, differentiation and cell growth is present in more than 80% of the primary melanomas, mutations and proteins in some way along the RAS-RAF-MEK-ERK. These mutations have been documented in all subtypes of melanoma, including the skin, in which mutations in BRAF and NRAS are more common. It was observed that BRAF was m…