Chemical Engineering degree from State University of Maringá (2000), master degree in Chemical Engineering from Federal University of São Carlos (2003) and PhD in Chemical Engineering from Federal University of São Carlos (2007). Pos-doctoral fellow at University of Sao Paulo (2008-2011) and Biotechnology Research Institute, National Research Council Canada (2009). Associate Professor at School of Pharmaceutical Sciences of Ribeirão Preto, University of Sao Paulo, since 2011. Her research area is focused on mammalian cell culture technologies for the production of recombinant proteins (biopharmaceuticals). She also works in the development of bioprocesses for the large-scale production of mesenchymal cells and CART-cell for cell therapy purposes. She is an associate researcher at the CTC (Center for Cell-based Therapy) FAPESP and National Institute of Science and Technology in Stem Cell and Cell Therapy in Cancer (INCTC) of the Blood Center of Ribeirão Preto, Medical School of Ribeirao Preto, Universidade of São Paulo. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
The Nucleus of Cellular Therapy - NuTeC will be founded on the union of the Regional Blood Center of Ribeirão Preto (Hemocentro RP) and Butantan. Hemocentro RP expertise in cellular therapy will be added to Butantan excellence in the development and production of health applied products to develop CAR T cell therapy. The activities to be conducted by NuTeC are aligned with the scope of th…
As células tronco/estromais mesenquimais humanas (MSC) exercem seu potente potencial regenerativo e imunomodulador por meio de pequenas vesículas extracelulares secretadas pelas mesmas, como os exossomos. Atualmente, a produção de exossomos é realizada em sistemas de cultura estáticos, que demandam tempo e trabalho excessivos, usando meios de cultura contendo soro fetal bovino, com purifi…
Today most complex biopharmaceuticals manufactured for human therapies are made commercially by use of the Chinese Hamster Ovary (CHO) cells as the "factory". Whilst the CHO cell line performs many of the required modifications (PTMs) during synthesis, specific PTMs (required for many proteins) are not performed. Human cells, with the capacity to perform human-specific PTMs, will present …
(Only some records are available in English at this moment)
Studies with the use of modified T lymphocytes with Chemical Antigen Receptors (CAR) present expressive results in the treatment of leukemias and lymphomas. Lentivirus are widely used with vectors of gene modification in this type of therapy, with the reason of their advantages, such as cell genome stability, transduction efficiency and safety. Monolayer cultivation is limited because it …
Currently, there is a large demand on drug production for oncology, mainly for bladder cancer treatment due to its high incidence. The development of a new drug evolves extensive analysis of effectiveness and safety during pre-clinical phase. Traditionally, cells cultured in monolayer, or 2D, have been applied for in vitro assays. However this model does not represent the best way to eval…
The use of chimeric antigen receptor (CAR) modified T lymphocyte immunotherapy has been shown to be effective in the treatment of chemotherapy and / or relapse resistant leukemias and lymphomas. Currently, lentiviral vectors are considered the most used gene modification vehicle of this therapy, offering significant advantages. Thus, with the growing interest in these vectors and the high…
(Only some records are available in English at this moment)
The current treatment of Pompe disease, a lysosomal storage disorder, is performed by enzyme replacement therapy using human recombinant alpha-glycosidase, produced in Chinese hamster ovary (CHO) cells. Despite the satisfactory results, cases of serious immunological reactions have been reported due to the differences between the recombinant protein and the native one. There is a growing …
Human coagulation factor VII (FVII) is a vitamin K-dependent glycoprotein that plays an important role in the blood coagulation process, being one of the key molecules involved in blood clot formation. Currently, the commercial product is produced in a murine cell line, BHK-21, which gives disadvantages considering the complexity of post-translational modifications of this protein. Murine…
The mesenchymal stromal cells ( MSCs ) have become of great interest for cell therapy because of their potential to differentiate and replenish specialized tissues . Can be isolated from diverse tissues, but the umbilical cord matrix (UCM) is a promising source of MSCs for clinical applications , because the cord is usually discarded and its collection is non- invasive . However, the numb…
| 1 / 1 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 10 / 9 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 18 / 17 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID