CV Lattes
Universidade Estadual de Campinas (UNICAMP). Centro de Hematologia e Hemoterapia (HEMOCENTRO) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciencias biologicas- Modalidade Médica from Universidade Federal de São Paulo (2008), master's at Biochemistry from Universidade Federal de São Paulo (2011) and doctorate at Biochemistry from Universidade Federal de São Paulo (2016). Has experience in Byophysics, acting on the following subjects: terapia genica, mucopolissacaridose i, sleeping beauty, vetores não-virais and mesenchymal stem cell. (Source: Lattes Curriculum)
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Sickle cell disease (SCD) is a serious condition, chronic and undoubtedly represents a public health problem in Brazil. The AF is caused by a point mutation in codon 6 of the ² globin gene, leading to a glutamic acid for valine substitution and results in the production of a structurally abnormal hemoglobin, hemoglobin S. Although the cause of the disease has been known for more than fift…
Recessive dystrophic epidermolysis bullosa (REBD) is a disease caused by the absence of type VII collagen in the skin of patients which provides a series of bubbles brought about by trauma, and wounds and inflammatory processes throughout the body, both internally and externally. Other minor problems are common in patients with REBD: contraction joints, hands and feet deformities, malnutr…
The monogenic RDEB is a very aggressive disease with no effective treatment yet. As patients suffering exclusively RDEB deficiency of collagen VII, the logical solution would be to provide this protein in the skin/epithelium continously throughout their lives, but how this solution can become a reality? Our proposal is to use hematopoietic stem cells from bone marrow to express the COL7…
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