Abstract
Sickle cell disease (SCD) is a serious condition, chronic and undoubtedly represents a public health problem in Brazil. The AF is caused by a point mutation in codon 6 of the ² globin gene, leading to a glutamic acid for valine substitution and results in the production of a structurally abnormal hemoglobin, hemoglobin S. Although the cause of the disease has been known for more than fift…