Associate Professor at Structural and Functional Biology- UNICAMP. She studied Biological Sciences at the University of Campinas (1999-2003). PhD in the Laboratory of Endocrine Pancreas and Metabolism, Department of Structural and Functional Biology, Institute of Biology of the same university, being part of this project developed at King's College London (2007-2008), in the Beta Cell Function Study Group. She was a Research Fellow at the Diabetes Study Group, Kings College London, 2009-2012, Fellowship in Diabetes-UK. Served as a Collaborative Researcher (Young Researcher-Fapesp Scholarship and Fellowship) in the Laboratory of Endocrine Pancreas and Metabolism (2013-2014). Currently, she is Adjunct Professor in the IB at University of Campinas, teaches students in the postgraduate course in Functional and Molecular Biology, and co-counselor in the postgraduate Multicentric course. She acts in undergraduate and postgraduate education and in the investigation of the molecular mechanisms involved in insulin secretion, beta cell maintenance and glycemic homeostasis. She has experience in the field of cell signaling, development and pancreatic beta cell function. She is an associate researcher at the Leopoldo de Meis National Network of Education and Science (RNEC). She is an associate researcher at the Obesity and Comorbidities Research Center (OCRC), UNICAMP, Chair of Undergraduate Studies at Institute of Biology-UNICAMP, and Vicente's mother. (Source: Lattes Curriculum)
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Decreased beta cell mass and secretory dysfunction are the main determinants of the pathogenesis of type 2 diabetes (T2D). Thus, improved understanding of the mechanisms regulating beta cell mass and secretory function will underpin strategies for maintaining appropriate blood glucose regulation and the development of novel therapies for T2D. In this context, the Wnt family proteins are o…
Dysfunctions in pancreatic beta cells can lead to impaired insulin production and secretion, cell death, and type 2 Diabetes mellitus (DM2). Understanding the mechanisms that regulate the synthesis of proteins involved in beta cell function and survival is of fundamental importance to understand how such dysfunctions could be avoided. The KH-type splicing regulatory protein (KSRP) modulat…
Type 2 diabetes mellitus (DM2) is an endocrine disorder characterized by the abnormally high concentration of glucose in the blood. The progressive decline of beta cell function by endoplasmic reticulum (ER) stress may occur in response to exposure to excess free fatty acids or inflammatory cytokines during the progression of DM2, activating the UPR (unfolded protein response). In this pr…
Type 2 diabetes mellitus (T2D) is a heterogenic disorder characterised by chronic hyperglycemia, due to the combination of insulin resistance in peripheral tissues and a deficient insulin secretion in pancreatic islets. The cholinergic stimulation is one of the most important mechanisms that regulate the beta-cell function, in which M3 muscaric receptor activation results in an increase i…
DM1 occurs due to genetic factors that lead to the destruction of beta cells in the pancreas by the immune system, causing a severe deficiency in insulin production. DM2 is characterized by a deficit in insulin production associated with insulin resistance. The production and the secretion of insulin are the main functions of the pancreatic beta cells. After an increase in the plasmatic g…
According to the World Health Organization, it is expected that by 2050 the world population over 60 years of age will double, reaching almost 2 billion. Aging is related to a greater propensity for the emergence of cardiovascular diseases, cancer, neurodegenerative diseases, type II diabetes mellitus, and changes in body composition and morphology, such as an increase in adipose tissue a…
Obesity results from an imbalance between energy intake and expenditure. It is often accompanied by insulin resistance, fasting hyperglycemia and several impairments in pancreatic beta cell function and survival, constituting one of the main risk factors for the development of Type 2 Diabetes Mellitus (T2D). Obesity is also associated with the development of hypothalamic inflammation, and…
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A diet rich in long-chain saturated fatty acids is capable of causing an inflammatory state in the central nervous system (CNS) by several means, among them elements the activation of the Toll-like receptor 4 (TLR4), resulting in the release of pro-inflammatory cytokines. Hypothalamic nuclei, related to the control of hunger and satiety, are usually compromised and become less responsive …
Obesity is defined as an excessive and abnormal accumulation of fat and is often associated with hypothalamic dysregulation. The consumption of high-fat diets has been considered the main factor responsible for inducing hypothalamic inflammation, commonly found in obese individuals. This inflammation has been associated with chronic hypothalamic resistance to the signs of anorexigenic and…
Nonalcoholic fatty liver disease (NAFLD) is an emerging concern because of its increased prevalence. This disease, caused by high food intake, corresponds to the accumulation of fat in the liver ranging from a simple steatosis to a steatohepatitis. NAFLD has been correlated with disorders such as obesity, insulin resistance and type 2 diabetes mellitus (DM2), which may be associated with …
(Only some records are available in English at this moment)
Activation of brown adipose tissue (BAT) increases energy expenditure (EE), and its activity is inversely correlated with body mass index and fat mass. BAT generates heat in response to cold exposure due to its unique expression of uncoupling protein 1 (UCP1) that dissipates energy by uncoupling the proton motive force from ATP production. Although UCP1 expression is restricted to BAT und…
| 2 / 2 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 19 / 16 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 29 / 26 | All research grants and scholarships |
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CV Lattes
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