Clélia Akiko Hiruma Lima

• Abstract

  The World Health Organization has been warning us of the obesity epidemic that affects people of all age groups and socioeconomic groups in both developed and developing countries. Therefore, studies have demonstrated the higher prevalence of other diseases associated with obesity, such as increased susceptibility to infectious conditions, inflammatory processes and chronic diseases, incl…

  Obesity induced by hypercaloric diet: evaluation of the action of Citral in metabolic inflammation, systemic and healing of gastric ulcers, AP.R

• Abstract

  Increased life expectancy has increased the demand for drugs useful in the treatment of chronic diseases, especially those affecting the digestive tract (gastric and duodenal ulcers, ulcerative colitis and Crohn's disease), diabetes, cancer and other inflammatory diseases. The use of standardized herbal drugs with efficacy and safety has presented some surprising results. In Brazil, there…

  Standardized herbal medicines for the treatment of chronic diseases, AP.BTA.TEM
• Gastric healing effect of methanolic and alkaloidic fraction from strychnos pseudoquina., AR.EXT

• Abstract

  Obesity is a chronic disease that is growing worldwide, due to distinct etiological factors. The High-Fat Diet (HFD) ingestion leads to a progressive increase in fat tissue and triggers metabolic changes. Possibly, this is caused by a change in the microbiota of the gastrointestinal tract (gut), characterized as a condition of intestinal dysbiosis. This change promotes an increase in lipo…

  Evaluation of the citral action in the intestinal permeability and metabolic endotoxemia in obese mice fed with high-fat diet, BP.DR

• Abstract

  Obesity is worrying and very prevalent in the world and in Brazil. The presence of comorbidities is very characteristic in obese patients, such as type 2 diabetes mellitus. During obesity, pro-inflammatory mediators are released by adipocytes, such as tumor necrosis factor (TNF) -±, interleukin (IL) -1², IL-6 and leptin, which promote a chronic inflammatory condition. In addition, there i…

  Can gastric healing be altered in obese animals? Evaluation of the antiulcerogenic effect of citral in mice treated with a high-fat diet, BP.IC

• Abstract

  Obesity is considered a public health problem, which has grown in several countries around the world. Ingestion of rich-fat diet leads to a progressive increase in adipose tissue and triggers changes in the modulation of the immune system, raising the levels of inflammatory mediators (TNF-±, IL-6 and leptin), which are considered systemic biomarkers. Low-grade chronic inflammation associa…

  Evaluation of action citral on lipopolysaccharide-induced fever in obese mice with high-fat diet, BP.MS

(Only some records are available in English at this moment)

• Abstract

  Obesity is a serious public health problem that affects worldwide. Intake of an unbalanced and fat-rich diet is one of the main factors that favor obesity development. In addition, it is being directly related to changes in the intestinal microenvironment that trigger systemic changes. Gut microbiota plays the commensal role with the host, ensuring the homeostasis of the intestinal microe…

  Investigation of the citral effect on the fecal microbiota of C57BL/6J mice fed with a high-fat diet, BE.EP.DR