Biomedical Science graduate from the Escola Paulista de Medicina (EPM) (1984), with a master's degree (1989) and a doctorate in Molecular Biology (1996) from the Federal University of São Paulo (UNIFESP), a master's degree in History of Science (2001) from the Pontifical Catholic University of São Paulo (PUC-SP). She did postdoctoral work at EPM-UNIFESP (1997) and at the Dana-Farber Cancer Institute (DFCI) / Harvard Medical School (2001-2003). She is a Full Professor of the Discipline of Molecular Biology at the Department of Biochemistry, advisor (since 2001), coordinator (2015-2022) and vice-coordinator (2022-current) of the Graduate Program in Molecular Biology at EPM-UNIFESP and member of the management committee of PROFBIO (Professional Master in Biology Teaching, UFMG). She is the coordinator of the INCT MODEL3D (National Institute of Science and Technology in Modelling Human Complex Diseases with 3D Platforms), she is a researcher at the INCT REGENERA (Regenerative Medicine) and at the RNTC (National Cell Therapy Network). She is the president of SBBC (Brazilian Society of Cellular Biology; 2020-2022; 2022-2024) and 1st treasurer of SBPC (Brazilian Society for the Progress of Science; 2021-2023). She is dedicated to neurobiology, studying neurogenesis in response to CNS injuries and neurodegenerative diseases; tissue bioengineering applied to the CNS, and fabrication of CNS biomimetic systems. (Source: Lattes Curriculum)
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Day 1 - Welcome and Course Overview, FAPESP Presentation, Day 2 - Topic 1 - Introduction to Stem Cell Biology, Topic 2 - Introduction to Development, Professional Development, Day 3 - Topic 2 - Introduction to Development, Topic 3 - Pluripotency and Reprogramming Professional Development, Day 4 - Topic 4 - Adult Stem Cells and Regeneration, Topic 5 - Cancer Stem Cell, Presentations by stu…
The concept of organ-on-a-chip refers to different types of in vitro modeling or reproduction of tissues and organs by combining cells and biocompatible material. This approach has become an attractive alternative for various studies, such as drug testing. The initial push was the worldwide effort to reduce the number of lab animals used in research, by the application of the 3R's - repla…
The biological process of neurogenesis that consists of differentiation of neural stem cells (NSC) into neurons, occurs both in embryonic and adult phases. Therefore, NSC are being proposed as interesting tools for nervous system tissue regeneration and restoration of physiological conditions, as well as models for elucidation of pathophysiological development of neurological diseases. Pr…
The new coronavirus SARS-CoV-2 emerged in December 2019, in China, and disseminated to several countries, causing an acute respiratory disease called COVID-19 (Coronavirus disease 2019). COVID-19 can evolve to severe respiratory infections resulting in high mortality index for people over 60 years of age or people that chronic diseases, such as diabetes, cardiac, and vascular diseases. CO…
(Only some records are available in English at this moment)
Neural progenitor cells derived from induced pluripotent stem cells (hNPCs) have great potential in terms of tissue repair due to their ability to differentiate and mature into other neural cell types, especially neuronal ones. In parallel, 3D bioprinting has also highlighted tissue engineering for its potential role in the study of tissue repair, and both, when combined, hNPC and 3D biop…
The use of artificial biological systems is vast and applicable in tissue engineering, in vitro, and in vivo assays. In these systems, the aim is to represent the complexity of native tissues, combining biomaterials, cells, and a great diversity of biomolecules. In order to obtain the best representation of the native tissue by the biomimetic tissue, it is essential to know the correlatio…
Animal models are considered the gold standard for Blood-Brain-Barrier (BBB) function studies. Although the use of in vivo models has contributed significantly to the advancement of the physiopathology of diseases that affect the BBB, they are limited regarding physiological differences between humans and rodents. To solve this problem, in vitro models have been proposed and developed, bu…
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The central nervous system (CNS) exhibits a limited regeneration process due to the formation of a glial scar after the occurrence of an injury. The glial scar acts as a barrier against the entrance of neuroblasts inside the injury, making it impossible to repair the neural synapses of that zone. The glial scar is formed by reactive astrocytes and oligodendrocytes that produce inhibitory …
Prokineticin 2 (PROK2) and its PKR2 receptor are expressed in different tissues and, in nervous tissue, they are found in neurons, astrocytes, and microglia. In the central nervous system (CNS), one of the PROK2 physiological functions is the chemotaxis of neuroblasts from the neurogenic niche of the subventricular zone to the olfactory bulb. In a model of traumatic brain injury (TBI) in …
In vitro models for the study of physiological processes and disease development of the Central Nervous System (CNS) have several limitations, such as poor representation of the three-dimensional (3D) cellular environment. As an alternative to two-dimensional (2D) cell cultures, 3D bioprinting represents an alternative to produce artificial, tissue-like structures with the possibility of …
(Only some records are available in English at this moment)
Current in vitro models of the Central Nervous System (CNS) present several limitations regarding poor representation of three-dimensional (3D) environments and as so, fail to reproduce the tissue's dynamics in health and disease. As an alternative to two-dimensional (2D) cell cultures, 3D bioprinting represents a new technology to produce artificial, tissue-like structures with the possi…
Astrocytes are activated by injuries to the central nervous system (CNS) and acquire an undifferentiated state, which is characteristic of neural stem cells (NSCs). In vitro these astrocyte-derived NSC-like cells regain multipotency and long-term self-renew, however, the molecular factors involved in astrocyte dedifferentiation are poorly understood. The purpose of this research project i…
Astrocytes are the first line of cellular response after a brain injury. To fulfil this role, astrocytes undergo a wide variety of alterations in gene expression and phenotype. Increasing evidence indicates that neurogenesis may have a regenerative role in response to brain injury and disease. Moreover, it has been suggested that, activation of signaling mechanisms regulating adult neural…
Brain injuries are potentially disabling, generate a high social cost and no neuroprotective/neuroregenerative strategies are clinically available at the moment. Stem cell therapy seems to be a promising strategy for brain repair. Two main strategies have been proposed: 1) exogenous stem cell transplantation, and 2) subventricular zone (SVZ) derived neural stem cell mobilization. The di…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
| 20 / 17 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 36 / 28 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 70 / 59 | All research grants and scholarships |
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