CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Bachelor's degree in Chemistry obtained from Universidade de São Paulo (1995), Master's degree in Biochemistry from Universidade Federal de São Paulo (1998) and Ph.d. in Biochemistry from Universidade Federal de São Paulo (2002). Has experience in protein chemistry, proteomics, bioinformatics and mass spectrometry. Major interests are focused on the development and clinical application of proteomics for biomarkers discovery and elucidation of molecular signatures of cancer. (Source: Lattes Curriculum)
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COVID-19 represents an unprecedented pandemic and tends to become endemic and recurrent due to the characteristics of the SARS-CoV-2 virus and its mutations. With the continuous increase in the number of cases worldwide, the lack of vaccines or effective treatments, the health system is significantly impacted by the high demand for resources to diagnose and treat patients. To understand t…
We propose a program of basic and clinical research to isolate, culture, and characterize embryonic ,somatic, and neoplastic stem cells in order to understand their biology and apply this knowledge to therapy, comprising four research lines: (1) pluripotent stem cells (SC) (embryonic SC and induced pluripotent SC); (2) somatic SC (hematopoietic SC, mesenchymal SC, endothelial SC, and canc…
Cancer is a leading cause of death worldwide and aging ls considered one of the most important risk factors for cancer. Aging is characterized by chronic low-grade inflammation and oxidant damage, which lead to endothelial senescence and disruption of vascular function. Inflammatory mediators released from senescent endothelial cells contribute to cancer by promoting mutations in neighbor…
The proteome is a multidimensional and highly dynamic system, in which proteins have interconnected properties that characterizes the phenotype of a cell or organism. The accurate measurement of such properties is vey challenging because of protein dynamics and diversity. Recent advances in proteomics mass spectrometry have driven integrated measurements of protein abundance, cellular loc…
The spread of metastasis to distant sites is the leading cause of death from cancer. Consequently, much effort in cancer research focuses on the detection, prevention, and treatment of distant metastases. The epithelial-mesenchymal transition (EMT) phenomenon, which occurs during normal embryonic development and tissue injuries, is also activated during the progression and metastasis from…
(Only some records are available in English at this moment)
Hematological malignances, accounts for around 25 thousand every year in Brazil. Among few therapeutic options, Chimeric Antigen Receptor (CAR) T lymphocytes cell therapy has emerged as a novel and effective therapeutic practice for the treatment of B-cell Leukemia and Lymphoma. For this autologous cellular immunotherapy, T-cells derived from patient blood are bioengineered in vitro to ex…
Cancer is a set of multifactorial diseases that generate disordered cell growth, forming malignant tumors that can invade adjacent tissues or distant organs, through the process of metastasis, which is responsible for the lethality of the disease. One of the molecular mechanisms that occurs during metastasis is the epithelial-mesenchymal transition (EMT). EMT is controlled by multiple fac…
Cancer is characterized as a set of multifactorial diseases that has in common the disordered growth of cells, which spread to other tissues and organs giving rise to metastases. During the metastasis, several changes comprise protein stability and translocation, including transport of proteins to the membrane, changes in the cytoskeleton, among others. Thus, during the cancer progression…
(Only some records are available in English at this moment)
Pancreatic cancer (PanCa) is among the most aggressive adenocarcinomas and difficult to diagnose. Since it develops silently and exhibits high genetic complexity, a reliable diagnosis is only possible when metastasis have already spread to secondary sites. Unfortunately, the two biomarkers for PanCa detection (carbohydrate antigen 19-9 and carcinoembryonic antigen) do not allow a reliable…
| 2 / 2 | Ongoing research grants |
| 5 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 14 / 9 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 23 / 17 | All research grants and scholarships |
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