Abstract
A major complication and limitation to the broad application of hematopoietic stem cell transplantation (HSCT) is graft-versushost disease (GvHD), which results from immune-mediated attack of recipient tissue by donor T cells contained in the transplant. GvHD accounts for 15-30% of deaths that occur following allogeneic HSCT (Ferrara et al., 2009). Despite recent advances to reduce the in…