CV Lattes
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Ministério da Ciência, Tecnologia e Inovações (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
got BSc (2000) and Master degrees from the Federal University of Pelotas (2003), Ph.D. in Chemistry from the Federal University of Rio Grande do Sul (2007) and the Université Joseph Fourier (France) and postdoctoral fellow at Oak Ridge National Laboratory/USA (2008-2009). He was a researcher of the Brazilian Nanotechnology Laboratory where he lead the Nanomedicine and Nanotoxicology Division. Nowadays, he is a researcher of the Brazilian Synchrotron Laboratory (Sirius) where he is the head of the Soft&Bio Materials Division. It is registered as advisor in the Graduate Program of Chemistry at UNICAMP. He has experience in the field of chemistry working mainly on the following themes: (a) synthesis of nanoparticles with biological activity against tumor cells, antibiotic-resistant bacteria and viruses; (b) sensors production based on nanoparticles and (c) data modeling the scattering of X-rays. More information can be found at www.mateuscardoso.org. (Source: Lattes Curriculum)
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Only a few nanoparticles (NPs) have passed FDA clinical trials for human use despite meaningful decades of in advances in NP drug-delivery systems and numerous published works. The proposal described here aims to understand the impact of protein presence on the ultimate location of nanoparticles inside mammalian cells. Silica particles containing fluorescent molecules such as Cy5, Alexa 6…
The proposal here described aims to synthesize fluorescent silica particles and coat them simultaneously with two distinct peptides using materials directing sequences to dock the functional biomolecules to the NP surface. The first is a RERERE-ending zwitterionic peptide, which will confer colloidal stability while avoiding protein corona formation around the particles. The second one is…
This project aims at the investigation of complex colloidal systems formed through the association of surfactants, polymers and nanoparticles. Its objectives are the understanding of the association processes involved in the formation of such systems, their structural characterization and elucidation of their properties, focusing on potential applications. The systems that will be investi…
The objective of this project is to design new functionalized silica nanoparticles (NPs) by using ionic liquids (ILs) based on imidazolium salts to avoid unspecific protein adsorption (protein corona). To overcome this challenge, various silylated ILs combined with different reactive functions (amine, acid) and counter anions will be synthetized, characterized and, then, grafted on silica…
The proposal described here aims to surface functionalization of mesoporous silica nanoparticles (NSMs) in order to increase the biological effectiveness and reduce the cytotoxicity. The aim is to improve performance and compatibility of biomedical structures. Within this context, three different systems but with similar characteristics will be investigated: (1) NSMs with bactericidal pro…
The project described here aims to functionalize the surface of two distinct types of composites: silica-antitumor drug and silver-silica composites. The aim is to improve performance and biomedical compatibility of these structures. The silica-antitumor drug composites will be functionalized with folate seeking to obtain a target specific structure, thus it is expected that this will be …
Recent advances in nanomedicine aim to develop safe nanomaterials with high biological performance and drug load, distribution, and delivery capabilities. In this context, nanoparticles (NPs) with biodegradable properties can avoid unwanted scenarios, such as bioaccumulation, and be safely cleared by the immune system after degradation. Still, little is understood about the evolution of N…
Nanoparticles are promising structures for the development of diagnostic and therapeutic agents. On the other hand, despite the great potential, the current stage of nanoparticles application in the Biomedical field is followed by a therapeutic efficacy lower than 1% when inserted in vivo. This low efficiency has been pointed out as the result of an underestimated comprehension of the int…
Protein corona is a phenomenon characterized by the spontaneous and nonspecific adsorption of proteins on nanoparticles' surface. This protein shell influences on the biological function of nanoparticles applied in Nanomedicine. Within this context, zwitterionic groups are among the compounds used to supress the protein corona formation. Nevertheless, in order to apply these nanoparticles…
(Only some records are available in English at this moment)
This project proposes the development of a platform composed of silica nanoparticles coated with oligomers of methacrylate gluconamide and functionalised with monoclonal antibodies that recognise a cell wall protein, with the possibility of being encapsulated with antibiotics. In this way, a multifunctional nanoparticle that aims to specifically bind bacteria without losing the biological…
Nanoparticles are promising structures for the development of diagnostic and therapeutic agents. On the other hand, despite the great potential, the current stage of nanoparticles application in the biomedical field is followed by a low therapeutic efficacy, less than 1 %, when inserted in vivo. This low efficiency has been pointed out as the result of an underestimated comprehension of t…
The Helicobacter pylori (H. pylori) a highly propagated bacterium, considering that it infects more than half of world population. The H. pylori is the main cause of gastric adenocarcinoma, which leads it to be classified by International Agency for Research on Cancer (IARC) as class 1 human carcinogen. Regarding this, the bacterium eradication is the most indicated treatment, since the H…
(Only some records are available in English at this moment)
Despite the numerous reports of effective nanoparticles in nanomedicine, very few nanoformulations have reached clinical trials. This wide gap is associated with issues of colloidal stability and protein corona formation once nanoparticles are introduced in biological media. Zwitterionic peptide have been proposed as surface coatings to provide high colloidal stability and avoid corona fo…
Cancer is known for its high mortality rates and for treatments which are often related to undesirable secondary effects. Therefore, the development of alternative methods for treating this disease is of paramount significance. Thus, a powerful strategy is the use of multifunctional nanoparticles (NPs), which have been extensively investigated in the recent years. NPs functionalized with …
Besides significant advances in the last centuries, humanity still suffer from a plenty of viral diseases for which we have no vaccines or specific treatments. Development of prevention or treatment measures for emerging viral diseases has been proven difficult and expensive. The solution to this problem may reside in molecules that are broadly active, protective against different viruses…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
| 3 / 3 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 16 / 16 | Completed scholarships in Brazil |
| 7 / 7 | Completed scholarships abroad |
| 33 / 33 | All research grants and scholarships |
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