graduation at Ciências biológicas from Universidade de São Paulo (1994), master's at Biochemistry from Universidade de São Paulo (1996) and doctorate at Microbiology from Universidade Federal de São Paulo (2001). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: trypanosoma cruzi, replicação, organização nuclear, ciclo celular and dna satélite. (Source: Lattes Curriculum)
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Vaccination is the touchstone of public health policies. The history of vaccination shows that vaccines have been empirically developed; therefore, many studies are still needed for the continuous development of this biological product. The effectiveness of vaccines is evaluated through the reduction of the infection or illness among vaccinated individuals, and it is influenced by many fa…
Chagas disease (CD) and Leishmaniasis are major health problems in the Americas, being Brazil and Colombia, countries where these diseases are epidemiologically significant. Despite the important health burden of these diseases, there is little investment by pharmaceutical companies, and the governments from endemic countries assign limited resources to health care. In addition, there are…
DNA replication must be closely controlled to ensure reliable maintenance of the genome in daughter cells. On the other hand, it is a process that can result in mutations. The balance between a careful process and an error-prone one results in higher or lower genetic variability. The aim of this project is to investigate the replication process in Trypanosoma cruzi, from the assembly of t…
(Only some records are available in English at this moment)
Pathogenic trypanosomatids such as Leishmania spp. and Trypanosoma cruzi are the causative agents of leishmaniosis and Chagas disease, a group of neglected diseases endemic in the tropical and subtropical belt of the planet and the Americas, respectively. The therapeutic approaches against these diseases are largely unsatisfactory due to toxicity and emergence of resistance. Thus, new dru…
(Only some records are available in English at this moment)
The DNA replication process during the cell cycle requires strict control to ensure genomic stability. In most eukaryotes, this process begins with the pre-replication complex (pre-RC) composed by the ORC hexamer and the Cdc6 and Cdt1 proteins, which associate with the DNA to allow the recruitment of the MCM complex, which has helicase activity, initiating the process of DNA denaturation.…
Trypanosoma cruzi is the etiologic agent of Chagas disease, also known as American trypanosomiasis. This disease is transmitted mainly by vector disease and estimated that 6 to 7 million people worldwide, a majority in Latin America, are infected with the parasite. Despite all research efforts with the Chagas Disease and much knowledge acquired, there is still no vaccine or treatment that…
Replication Protein A (RPA), the main single-stranded DNA ligand of eukaryotes, is a heterotrimeric complex formed by three subunits (RPA-1, RPA2 and RPA-3) and participates in several fundamental processes such as replication, repair and signaling checkpoint. Our group found that, depending on the life form of the parasite, RPA is found in the nucleus (in replicative forms) or in the cyt…
This project aims, in general, to synthesize new derivatives of benznidazole, an anti-chagasic agent already used by ANVISA and FDA. The research is based on obtaining the desired derivatives, by the N-alkylation reaction of 2-nitro-imidazole, through sodium chloroacetate and subsequent acidification of the carboxylate, in order to obtain the carboxylic acid derivative. Another part of th…
Trypanosoma cruzi is the etiologic agent of Chagas' disease. Despite being the largest cause of heart disease-induced infection, there is no vaccine, and the only available drugs have serious side effects. Efforts to generate new therapies are hampered by limitations in our understanding of parasite biology. During the life cycle, T. cruzi alternates between proliferative (amastigote and …
DNA Double Strand Breaks (DSBs) are one of the most toxic forms of DNA damage. These can arise accidentally during normal cell metabolism or after exposure of cells to DNA-damaging agents. Failure to repair them can result in genomic instability, a characteristic of cancer cells. In eukaryotes, DSBs are repaired by Homologous Recombination (HR) and Non-Homologous End-Joining (NHEJ). In HR…
(Only some records are available in English at this moment)
DNA double strand breaks (DSBs) are one of the most toxic forms of DNA damage. These can arise accidentally during normal cell metabolism or after exposure of cells to DNA-damaging agents. Failure to repair them can result in genomic instability, a characteristic of cancer cells. In eukaryotes, DSBs are repaired by homologous recombination (HR) and non-homologous end-joining (NHEJ). In HR…
Trypanosoma cruzi is a protozoan which belongs to the Trypanosomatidae family and it is the etiological agent of Chagas disease, a neglected disease that affects millions of people worldwide. This parasite alternates between replicative (epi and amastigotes) and non-replicative (trypomastigotes) forms in its hosts. Therefore, it needs intense control of DNA replication, which involves coo…
DNA replication is a biological process of paramount importance, mainly because it drives the propagation of all living organisms, being the basis of genetic inheritance. The earliest step of DNA replication is the establishment of origins, which are defined as genomic loci where DNA synthesis initiates, being preceded by the binding of a replication initiation factor. The binding of the …
Replication protein A (RPA) is a heterotrimeric complex involved in many aspects of DNA metabolism, such as replication and DNA damage responses (DDR). Post-translational modifications (PTM) are important for RPA regulation and to support the multiple functions that RPA mediates. In mammalian cells following DNA damage RPA is phosphorylated at multiple sites, and which serve to initiate …
| 4 / 4 | Ongoing research grants |
| 8 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 24 / 13 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 43 / 30 | All research grants and scholarships |
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CV Lattes
ORCID