graduation at Ciências biológicas from Universidade de São Paulo (1994), master's at Biochemistry from Universidade de São Paulo (1996) and doctorate at Microbiology from Universidade Federal de São Paulo (2001). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: trypanosoma cruzi, replicação, organização nuclear, ciclo celular and dna satélite. (Source: Lattes Curriculum)
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Vaccination is the touchstone of public health policies. The history of vaccination shows that vaccines have been empirically developed; therefore, many studies are still needed for the continuous development of this biological product. The effectiveness of vaccines is evaluated through the reduction of the infection or illness among vaccinated individuals, and it is influenced by many fa…
DNA replication must be closely controlled to ensure reliable maintenance of the genome in daughter cells. On the other hand, it is a process that can result in mutations. The balance between a careful process and an error-prone one results in higher or lower genetic variability. The aim of this project is to investigate the replication process in Trypanosoma cruzi, from the assembly of t…
Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan Institute historically built its strong international reputation. Indeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic…
Trypanosomatid parasites, namely Trypanosoma cruzi, Leishmania spp., and Trypanosoma brucei, are the etiological agents of Chagas disease, leishmaniasis, and sleeping sickness, respectively. Collectively, these illnesses have a profound impact on public health worldwide. A hallmark of these parasites is their genomic plasticity, primarily through gene and chromosomal copy number variation…
Chagas disease (CD) and Leishmaniasis are major health problems in the Americas, being Brazil and Colombia, countries where these diseases are epidemiologically significant. Despite the important health burden of these diseases, there is little investment by pharmaceutical companies, and the governments from endemic countries assign limited resources to health care. In addition, there are…
(Only some records are available in English at this moment)
DNA replication is essential for cell replication, and therefore it is a complex and tightly controlled process. Problems in the DNA replication process can lead to gene mutation, recombination and amplification or deletion events. DNA replication starts in genomic regions named replication origins that are recognized in eukaryotes by the heterohexamer Origin Recognition Complex (ORC). Ac…
(Only some records are available in English at this moment)
In this proposal, we intend to improve the biological knowledge of Trypanosoma cruzi, which causes Chagas disease, focusing on the correlation between cell cycle, differentiation and epigenetics. Throughout the T.cruzi life cycle, different life forms are found in the invertebrate vector and the mammalian host. These forms adapted to distinct environmental conditions and thus differ in te…
(Only some records are available in English at this moment)
DNA double strand breaks (DSBs) are one of the most toxic forms of DNA damage. These can arise accidentally during normal cell metabolism or after exposure of cells to DNA-damaging agents. Failure to repair them can result in genomic instability, a characteristic of cancer cells. In eukaryotes, DSBs are repaired by homologous recombination (HR) and non-homologous end-joining (NHEJ). In HR…
Trypanosoma cruzi is a protozoan which belongs to the Trypanosomatidae family and it is the etiological agent of Chagas disease, a neglected disease that affects millions of people worldwide. This parasite alternates between replicative (epi and amastigotes) and non-replicative (trypomastigotes) forms in its hosts. Therefore, it needs intense control of DNA replication, which involves coo…
DNA replication is a biological process of paramount importance, mainly because it drives the propagation of all living organisms, being the basis of genetic inheritance. The earliest step of DNA replication is the establishment of origins, which are defined as genomic loci where DNA synthesis initiates, being preceded by the binding of a replication initiation factor. The binding of the …
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
| 10 / 8 | Completed research grants |
| 8 / 8 | Ongoing scholarships in Brazil |
| 28 / 17 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 53 / 40 | All research grants and scholarships |
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CV Lattes
ORCID