Graduated in Biotechnology from São Paulo State University, Brazil (2008). Master's degree (2010) and PhD (2014) in Health Sciences, at the São José do Rio Preto Medical School, Brazil. Postdoctoral at Barretos Cancer Hospital, Molecular Oncology Research Center (2014-2018) and PostDoctoral associate at University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, EUA (2018-2020). Experience in Genetics and Molecular Biology, working mainly in biomarker research for head and neck tumors (DNA methylation, microRNAs, mutations, polymorphisms), cell culture (cytotoxicity and therapeutic response to drugs) and tumor immunology, mainly investigating immunological markers of response to immunotherapy (anti-PD-1/PD-L1 and anti-CTLA-4, BCG and imiquimod). Associate researcher and supervisor in the Graduate Program at Institute of Learning and Research, Barretos cancer hospital. Coordinator of the Immuno-Oncology group and discipline at the HCB graduate program. Coordinator of the Barretos Cancer Hospital team in the international consortium "Translational studies of HEAD and neck cancer in South America and Europe (HEADSpAcE)", led by the International Agency for Research on Cancer (IARC) and funded by the European Union. (Source: Lattes Curriculum)
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Cancer immunotherapy is based on the premise that tumors can be recognized and can be attacked by an activated immune system. However, tumor cells develop mechanisms to thwart immune recognition and response. The immune checkpoints modulate the homeostasis of co-stimulatory and co-inhibitory signals, which are critical to maintaining immune tolerance besides modulating the physiological i…
Introduction: Valproic acid is a drug with potential therapeutic action in preventing undesirable outcomes in patients who have finished treatment for head and neck cancer, considering that it acts on epigenetic mechanism by inhibiting histone deacetylase, which regulates the expression of different genes. Functional assesment of the response to valproic acid as well as its toxicity can b…
(Only some records are available in English at this moment)
Head and neck cancer (HNSCC) is a disease with high incidence and mortality mainly affecting the oral cavity, pharynx and larynx, it is considered to be the fth most common cancer site worldwide and is associated with low survival rates. The poor survival rate has been ascribed to a high frequency of locoregional recurrences, and the occurrence of second primary tumors and deaths due to c…
(Only some records are available in English at this moment)
Among the features characterizing the tumor microenvironment (TME), oxygen shortage, namely hypoxia, constitutes a hallmark of most cancer types. It is linked to immunosuppression and associated with the dysregulation of the cellular epigenetic machinery. Interestingly, the differentiation status and functionality of CD8+ T cells are defined by their epigenetic programs. Since the absence…
Programmed Death 1 (PD-1) and T cell Ig and mucin domain-3 protein (Tim-3) are immune checkpoint receptors that are expressed on tumor-infiltrating lymphocytes (TIL) in tumor-bearing mice and humans. As anti-PD-1 single agent response rates are only <20% in head and neck squamous cell carcinoma (HNSCC) patients, it is important to understand how multiple inhibitory checkpoint receptors ma…
| 1 / 1 | Ongoing research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 6 / 4 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 15 / 13 | All research grants and scholarships |
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