Bachelor degree in Biomedical Sciences by the Federal University of Sao Paulo (2002). Graduated in Molecular Biology by the Federal University of Sao Paulo (2007), participating also in a graduate exchange program at the Max-Delbrück Institute for Molecular Medicine (Berlin, Germany). Postdoctoral fellow at Joslin Diabetes Center/Harvard Medical School (Boston, USA). Assistant Professor at the Department of Biophysics of the Federal University of Sao Paulo from 2011 to 2016. Currently holds a position of Associate Professor in the Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, serving as the head of Department from 2017 through 2021. He was also Research Coordinator of the Institute of Biology in the period of 2018-2020. Expertise in Molecular Biology with emphasis in Metabolism, dedicated mainly in investigating the molecular mechanisms associated with the Metabolic Syndrome and the Aging process. Former affiliated member of the Brazilian Academy of Sciences. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| En un gusano, los frenos del envejecimiento |
| Worm may help put the brakes on aging |
| En un gusano, los frenos del envejecimiento |
| News published in Agência FAPESP Newsletter about the researcher |
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What shapes the rate of aging of a given species or individual? Despite the recent advances in the field of biogerontology, this fundamental question remains without a comprehensive answer. Nutrition, reproduction and exposure to environmental threats (such as pathogens) are among the most important driving forces shaping life history. At the cornerstone of how these elements impact lifes…
What shapes the rate of aging of a given species or individual? Despite the recent advances in the field of biogerontology, this fundamental question remains without a comprehensive answer. Nutrition, reproduction and exposure to environmental threats (such as pathogens) are among the most important driving forces shaping life history. At the cornerstone of how these elements impact lifes…
The overarching aim of this proposal is to delineate the common molecular networks in adipose tissue involved in the lifespan and health promoting effects of dietary restriction and its mimetics such as dietary methionine restriction (MR) and dietary supplementation with nicotinamide riboside (NR) - a dairy constituent that maintains NAD metabolism. To achieve that, we designed a pipeline…
(Only some records are available in English at this moment)
A number of pathways have been shown to regulate animal lifespan and organismal aging. The Antebi lab has recently discovered the nucleolus as a crucial focal point for these pathways. The nucleolus is a subnuclear organelle dedicated to rRNA production and ribogenesis, which also controls other key processes in the RNA metabolism of the cell, including small RNA processing and assembly o…
COVID-19 has recently emerged as an age-related disease whose mechanisms are still poorly understood. Using a combination of hypothesis-oriented and unsupervised, data-driven approaches, as well as patients and pre-clinical models, we expect to come up with candidate proteins and pathways which could not only predict the susceptibility to the disease, but also unveil the molecular mechani…
Dr. Jeremie Boucher is a Principal Scientist at AstraZeneca, R&D CVMD iMed and Group Leader at the Wallenberg Centre for Molecular and Translational Medicine in the University of Gothenburg, where he leads bench-to-bedside projects focused on finding new molecules targeting metabolic diseases. Dr. Boucher and AstraZeneca have established a collaboration with the laboratory of Dr. Marcelo …
(Only some records are available in English at this moment)
The use of drugs that decrease the senescence cell burden is currently among the most promising therapeutic venues to treat age-associated diseases and reverse aging. We will test the role of senotherapeutics using a translational approach with the focus on developing new strategies to improve immunity and counteract metabolic dysfunction and reproductive senescence that are accompanied b…
The processes of aging and decline in the functioning of the immune system are strongly related, and the nematode Caenorhabditis elegans has been shown to be an appropriate model for the study of both. Caloric restriction is an intervention capable of modulating the activity of signaling pathways related to both the control of lifespan and the functioning of the immune system. A compound …
The thymus plays a central role in generating the T cells repertoire - a phenomenon orchestrated by thymic epithelial cells (TECs). The proper functionality of the selection processes exerted by TECs is crucial to guarantee a functional pool of effector T cells. Interestingly, selection occurs prior to puberty, before the thymus begins involuting and lymphostromal thymic zones are progres…
(Only some records are available in English at this moment)
COVID-19 has emerged as an age-related disease whose mechanisms are still poorly understood. Using a combination of hypothesis-oriented and unsupervised, data-driven approaches, as well as patients and pre-clinical models, we expect to come up with candidate proteins and pathways which could not only predict the susceptibility to the disease, but also unveil the molecular mechanisms throu…
COVID-19 has emerged as an age-related disease whose mechanisms are still poorly understood. Using a combination of hypothesis-oriented and unsupervised, data-driven approaches, as well as patients and pre-clinical models, we expect to come up with candidate proteins and pathways which could not only predict the susceptibility to the disease, but also unveil the molecular mechanisms throu…
There is a worldwide trend towards aging of the world's population, what gives rise to social, economic and public health issues. Caloric Restriction (CR) is an intervention that slows down the aging process in different species resulting in a reduction in the risk of age-related diseases. Aging and CR affect the cells of the organism in an indiscriminate manner. However, some cells seem …
(Only some records are available in English at this moment)
Cardiovascular diseases (CVD) are the main cause of death worldwide, being responsible for around 31% of all deaths whereas obesity is an independent risk factor for the development of CVDs. Adipocytes extensively communicate with other organs via hormones called adipokines, and, as more recently demonstrated, via microRNAs (miRNAs). Our group has shown that the adipose tissue expression …
Population aging represents a relevant public health issue, justifying the pursue of interventions aiming to promote health in the elderly. In the aging process, cells tend to lose the ability to properly respond to endogenous and exogenous stressors, and one relevant stress related to aging is oxidative stress. High levels of pro-oxidant molecules associated with decreased antioxidant ca…
Increased calorie intake and reduced energy expenditure are the main etiological factors in obesity. On the other hand, increased brown adipose tissue activity and recruitment of beige adipocytes are proposed to antagonize obesity-related complications. miRNAs are important regulators of metabolic processes. These small molecules are generated by a pathway that includes the rate limiting …
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing research grants |
| 7 / 7 | Completed research grants |
| 12 / 12 | Ongoing scholarships in Brazil |
| 42 / 37 | Completed scholarships in Brazil |
| 8 / 8 | Completed scholarships abroad |
| 73 / 68 | All research grants and scholarships |
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CV Lattes
ORCID