bachelor's at Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (1992), master's at General Biology from Universidade Estadual de Campinas (1994) and doctorate at Biochemistry from Universidade Estadual de Campinas (1998). Has experience in Pharmacy, focusing on Pharmacy, acting on the following subjects: cultura de células, matriz extracelular, melanoma, crescimento tumoral and invasion and metastasis. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Piel de laboratorio |
| Laboratory Skin |
| Recreated skin |
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
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| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
The progress in reconstruction of an in vitro three-dimensional skin model that accurately represents the complex human skin microenvironment depends on the advance of tissue engineering. In this way, the 3D bioprinting technique is an emerging technology that allows the precise, hierarchical and automated deposition of cells and biomaterials for the construction of mimetics with greater …
Melanoma is a highly invasive and metastatic cancer, with high rates of mortality and chemoresistance. The MAPK pathway is constitutively activated, and there are already available powerful target-specific chemotherapeutics, such as BRAF inhibitors (vemurafenib and dabrafenib). However, resistance to BRAF inhibitors is observed after about 7 months of treatment, primarily because of the h…
(Only some records are available in English at this moment)
The skin is the largest organ in the human body and its main function is to act as a barrier against external agents. Atopic dermatitis (AD) is one of the most prevalent inflammatory skin diseases and is considered an expensive and difficult-to-control disease. It is estimated that at least 230 million people worldwide are affected by this condition. AD is a chronic disease that involves …
Human exposure to nickel (Ni), including dermatological exposure, result from contact with objects containing this metal, occupational exposure and environmental pollution. Ni is considered a skin sensitizing metal and allergies induced by it are among the main causes of contact dermatitis in industrialized countries. It is well demonstrated that, under physiological conditions, Ni in met…
Melanoma is the type of skin cancer with the highest metastatic potential, resulting in its high mortality rate. The main mutations in melanoma occur in the MAPKs pathway: 50% of patients have alterations in BRAF; 15-20% in NRAS and mutations in NF1 or triple wild-type tumors account for the remaining cases. Although targeted therapy has revolutionized the treatment for melanoma through t…
(Only some records are available in English at this moment)
Melanoma is the less common type of skin cancer, but it is the most aggressive. The most of patients harbor mutations in BRAF (V600E) protein, and its specific inhibitor vemurafenib has revolutionized the treatment of the disease. However, resistance to long-term therapy is recurrent, leading to treatment failure. Besides the acquired resistance, the many different mutations responsible f…
Melanoma is a malignant neoplasm that originates from melanocytes and represents a major public health problem. Although it accounts for only 3% of skin cancers, it is responsible for 80% of malignant neoplasms related to this organ. This is due to the fact that metastatic melanoma is refractory to conventional and targeted therapies and rapidly acquiring resistance to the specific inhibi…
(Only some records are available in English at this moment)
In cancer, intra-tumour phenotypic heterogeneity imposed by a dynamic microenvironment is increasingly recognized as a source of drug-resistance and a driver of metastatic spread. The in vivo microenvironment is highly complex and cancer cells will be exposed to a wide range of stresses including oxygen and nutrient limitation. The ability of cells to respond to the stresses encountered i…
Melanoma represents the deadliest of all skin cancers. The comparison of melanoma incidence and mortality rates indicated a worse prognosis with increasing age. Patients with melanoma demonstrated an inverse correlation of melanoma mortality and incidence of sentinel node metastasis in young and old patients. The Wnt5A and HAPLN1 proteins are altered in the aged microenvironment, they see…
Nowadays billions of people use hair dyes, among them, the most representative class are the permanent hair dyes reaching up to 80% of worldwide consumption. Permanent hair dyes are formed after successive reactions between a primary intermediate (ex. p-phenylenediamine) and a coupler (ex. Resorcinol) that after oxidative reactions with hydrogen peroxide (H2O2) results in permanent color …
(Only some records are available in English at this moment)
| 16 / 14 | Completed research grants |
| 7 / 7 | Ongoing scholarships in Brazil |
| 32 / 23 | Completed scholarships in Brazil |
| 9 / 7 | Completed scholarships abroad |
| 64 / 51 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID