Graduated in Biological Sciences (1977) and Ph.D. in Biochemistry (1981) by the Universidade de São Paulo. Postdoctoral fellow at the Institute Pasteur, Paris (1981-83) and at the EMBL Heidelberg, Germany (1983). He became Assistant Professor at the Universidade Federal de São Paulo (1984) and joined the New York University Medial Center (1988-91). In 1997 he became Full Professor of Microbiology at the Federal University of São Paulo, Brazil. He is currently member of the Editorial board of Microbes and Infection, Cellular Microbiology, and Protein and Peptide Letters. His research is in the area of Molecular and Cell Biology of Trypanosomes with focus on studies of sialidases, gene expression regulation and nucleus organization. (Source: Lattes Curriculum)
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Parasitic protozoa of Trypanosoma and Leishmania species, respectively agents of Chagas disease and leishmaniasis, control their gene expression mainly through post-translational mechanisms. This is due to the selection of mRNAs that will be translated in each environment in which the parasites are located. During the passage from one host to another, changes occur in the availability of …
Protozoan parasites, which are major human pathogens in both Brazil and Israel, were shown to release extracellular vesicles (EVs) into the host microenvironment, and these are known to modulate the intracellular communication between pathogens and hosts. Although these EVs have been characterized and shown to play important roles in the establishment of infection, specific processes invo…
Response mechanisms of protozoan parasites to the situations found in the hosts is not well known. This understanding can help to identify new chemotherapeutic targets and on the comprehension of the mechanisms that lead to pathogenesis. Our group has studied for last several years, how protein synthesis is regulated in Trypanosoma under stressing conditions. In this thematic project, we …
(Only some records are available in English at this moment)
The main objective of this project and which will be developed by the postdoctoral student in this period will be related to the control of translation and formation of RNA granules and the relationship of these processes with the secretion of extracellular vesicles by Trypanosomes. For this, we intend to: 1) generate parasites containing TcK1, K2 and K3 Tags generated by CRISPR/Cas9. The…
In this project we will evaluate in Trypanosoma cruzi, the protozoan causing Chagas Disease, the role of phosphorylation of eIF2± in the response to different stresses and the activation of AMPK, sensor of the energy state of eukaryotic cells. During nutritional stress eIF2± is phosphorylated, decreasing protein synthesis, and leading to differentiation to the infective form of the parasi…
In our laboratory we obtained parasites expressing subunit alpha1 and alpha 2 as well as the gamma subunit of the AMPK protein kinase of T. cruzi containing the myc peptide sequence using the CRISPR/Cas9 technique. We also found that these subunits are phosphorylated when parasites are incubated with glucose oxidase and glucose to produce hydrogen peroxide. Thus, we intend to immunoprecip…
The Trypanosoma cruzi is a flagellate protozoon that cause of Chagas disease in man. In its life cycle, T. cruzi presents a high capacity of environmental adaptation. However, the mechanisms that signal this adaptation are not yet well known. It possibly depends on the availability of nutrients. One of the main mechanisms involved in the control of the energy state of eukaryotes cells occ…
The present PhD project, entitled "Characterization of TcCyp19 and evaluation of its role during the cellular infection by Trypanosoma cruzi", was initiated by the joint work of Prof. Sergio Schenkman with Prof. Bradford Mcgwire of Ohio University who initiated studies showing the expression of cyclophilin 19 (TcCyp 19) in T. cruzi, the protozoan parasite that causes Chagas' disease. They…
(Only some records are available in English at this moment)
Lysine acetylation has emerged as a major post-translational modification involved in diverse cellular functions in higher eukaryotes. While histone proteins are the founding members of lysine acetylation substrates, it is now clear that hundreds of other proteins can be acetylated in multiple compartments of the cell. During its life cycle the Trypanosoma cruzi face different environment…
| 1 / 1 | Ongoing research grants |
| 19 / 18 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 49 / 13 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 72 / 35 | All research grants and scholarships |
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CV Lattes
ORCID