Humberto D'Muniz Pereira

• Abstract

  Schistosoma mansoni do not have de novo purine pathways and rely on purine salvage for their purine supply. It has been demonstrated that, unlike humans, the S. mansoni is able to produce adenine directly from adenosine, although the enzyme responsible for this activity was unknown. In the present work we show that S. mansoni 5´-deoxy-5´-methylthioadenosine phosphorylase (MTAP, E.C. 2.4.2…

  Crystal Structure of Schistosoma mansoni Adenosine Phosphorylase/5'-Methylthioadenosine Phosphorylase and Its Importance on Adenosine Salvage Pathway, PUB.ART

• Abstract

  In the 70's Senft and coworkers published a series of articles demonstrating that S. mansoni was unable to incorporate both glycine and glucose in the purine ring indicating the lack of a "de novo" purine pathway in the parasite and highlighting its dependence on imported host's purine . Genes coding for all purine salvage enzymes were found in the S. mansoni genome. In S. mansoni, the p…

  Structural and kinetical studies of the enzymes involved in the purine metabolism in Schistosoma mansoni, AP.R
• XXII Congress and General Assembly of the International Union of Crystallography (IUCr), AR.EXT

• Abstract

  Neglected tropical diseases are considered a public health problem and were primarily related to poverty and low economic development. These neglected diseases account for a major cause of death in developing countries, receiving little or no attention from pharmaceutical companies for the development of therapies. Schistosoma mansoni is the parasite responsible for schistosomiasis. Schis…

  Expression, purification, activity assay and crystallization of UCK1 and UCK2 enzymes of the pathway salvation pyrimidines from the parasite Schistosoma mansoni, BP.IC

• Abstract

  Neglected tropical diseases are considered a major public health problem, being mainly related to poverty and low economic development. These neglected diseases account for a major cause of death in developing countries, receiving little or no attention from pharmaceutical companies for the development of therapies. Schistosoma mansoni is the parasite responsible for schistosomiasis. Schi…

  Expression, purification, activity assay and crystallization of the enzyme UCMP kinase from biosynthesis of pyrimidine nucleotides of the parasite Schistosoma mansoni, BP.IC

• Abstract

  Schistosomiasis is a neglected disease that doesn't attract large investments of the pharmaceutical companies in the search and development for new potential drugs. The enzyme Deoxycytidylate deaminase (DEOC) is one of the enzymes that belongs to the thymidylate cycle of the parasite Schistosoma mansoni. The thymidylate cycle is an essential metabolic pathway of the parasite and the enzym…

  Kinetic and structural studies of the Deoxycytidylate deaminase (DEOC) from Schistosoma mansoni, BP.IC

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