J.A.M. Barbuto graduated in Medicine by the Faculty of Medicine, University of Sao Paulo, has a Master's degree in Microbiology and Immunology, by the "Escola Paulista de Medicina" (Federal University of Sao Paulo) and a Ph.D in Immunology by the University of Sao Paulo. Currently he is an Associate Professor in the University of Sao Paulo. He has experience in cellular immunology, focusing in cancer immunotherapy, and studies mainly dendritic cells, their pathophysiology and clinical applications. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Surge una posible vacuna contra el cáncer causado por el VPH |
| Vaccine candidate designed to treat cancer caused by HPV |
| News published in Agência FAPESP Newsletter about the researcher |
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Due to the relative lack of success of the existent treatments against lung cancers, it is of utmost urgency to develop new, efficient and selective therapies against this disease that is responsible for millions of deaths worldwide. In this regard, the purpose of this proposal is the development of a novel class of drugs candidates, which might offer the possibility of a disease free lif…
Dendritic cells (DCs) constitute key elements that influence strongly the consequences of an encounter of the organism with any antigen. Immune response patterns, ranging from tolerance to antigen elimination or the establishment of immunopathological states depend on the way DCs interact with T lymphocytes. Our laboratory has been studying DCs and found many intriguing behaviors of these…
Dendritic Cells (DCs) are the major antigen presenting cells and the possibility of their generation in vitro has renewed the interest in immunotherapy protocols. However, their study shows that they are functionally heterogeneous and under poorly defined control mechanisms. The unravelling of such mechanisms may allow DCs exploitation in more efficient immunotherapy protocols. Therefore,…
(Only some records are available in English at this moment)
Among the immunotherapies, the CAR-T cell therapy has been standing out in the past few years, given the promising results obtained for hematologic malignancies. The insertion of a CAR (Chimeric Antigen Receptor) molecule in the T cells provides an antigen specific and MHC (Major Histocompatibility Complex) independent antigen recognition. The CAR-T cell products currently approved for cl…
Breast cancer, the main neoplasm that affects women in the world, despite having high cure rates when detected in its initial state still ranks in second among causes for cancer related death in women. Among the current standard-treatment possibilities, chemotherapy and hormone therapy are the ones who stand out the most, however, patients with metastatic, aggressive and/or relapsed disea…
Dendritic cells are the main professional antigen-presenting cells of the human body, having a major role in the innate and adaptive immune responses. It has been researched a lot about the effects of different cytokines on these cells, however, recent studies - highlighting the molecular biology field - suggest that knowledge about the metabolism of the dendritic cells may be essential f…
Gliomas are tumors of the central nervous system, among which glioblastoma (GBM) is the most aggressive, invasive, undifferentiated and common in adults. Despite the different classifications of GBM, taking into account various genetic and molecular aspects, the standard treatment for this neoplasm is "maximum" surgical resection, followed by concomitant treatment with Temozolomide (TMZ) …
Cervical cancer is the fourth most lethal type of cancer in women worldwide. Despite available treatments, cervical cancer remains a global public health problem. Therefore, the search for new therapeutic approaches for this type of cancer is a priority. This project aims to study the clinical-oncological and immunological parameters of patients with high-grade cervical intraepithelial ne…
(Only some records are available in English at this moment)
Dendritic cells (DCs) are a subtype of cells specialized in antigen capture, processing and presentation, thus triggering the response of T lymphocytes. DCs may generate immunity or tolerance, depending on the extracellular signals they receive. DCs that receive tolerogenic signals, such as 1,25(OH)2D3, are characterized by their ability to generate, , CD4+CD25+FoxP3+ T lymphocytes or to…
The study is based on previous findings on a series of substituted-[N'-(benzofuroxan-5-yl)methylene] benzohydrazides which have shown potent cytotoxic effects against a variety of malignant tumor cells that overexpress MDMX protein. MDMX is responsible for the functional deficiency of p53 in tumors, like melanoma, which show this deficiency even though they do not have mutations in p53. H…
It is well known that, sometimes, the adaptive immune response is able to specifically recognize and eliminate tumor cells, a characteristic that has been exploited in the development of immunotherapeutic protocols. This is only possible because, during the tumorigenesis, transformed cells accumulate changes in protein sequence (mutations) and expression pattern, generating tumor-associat…
(Only some records are available in English at this moment)
| 12 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 55 / 28 | Completed scholarships in Brazil |
| 9 / 9 | Completed scholarships abroad |
| 79 / 44 | All research grants and scholarships |
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CV Lattes
ORCID