Camila Squarzoni Dale in research grants and scholarships supported by FAPESP.
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Herpetic (HN) and postherpetic (PHN) neuralgia characterize herpes zoster pain, as burning, spontaneous pain, allodynia, and hyperalgesia. Although the literature indicates inflammatory and neuropathic processes as causes, the mechanisms described are still imprecise, and animal models for the study of HP and PHN are incomplete regarding central and peripheral sensitization in the nervous…
Opioides have an addictive effect generate tolerance upon prolonged use causing unwanted side effects. Thus, there is a great need to search for new analgesic substitutes. To this end, understanding the signaling pathways that lead to pain can help develop new non-opioid analgesics. Inflammatory pain begins with the secretion of nerve growth factor (NGF) and activation of its high affinit…
Diabetic neuropathy (DN) is one of the most common complications of diabetes, affecting about 50% of diabetic patients. Among the various symptoms of DN, the development of chronic pain, which mainly affects the extremities, is manifested as exacerbated responses to noxious stimuli (hyperalgesia) and pain in response to mild or non-painful stimuli (allodynia). Conventional treatments avai…
Peripheral neuropathy (PN) caused by diabetes mellitus is one of the most common complications of diabetes, affecting about 50% of patients with the disease. Among the many symptoms of NP, stands out the development of chronic pain, which affects mainly the extremities, presenting itself as exacerbated responses to noxious stimuli (hyperalgesia) and as pain in response to light or not pai…
(Only some records are available in English at this moment)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory with impaired cognitive functions. The two subtypes are familial AD, influenced by a genetic mutation with subsequent metabolism / abnormal extracellular deposition of the beta amyloid peptide (bA) and collapse of the cytoskeleton by hyperphosphorylation of the tau protein in the hippocamp…
Herpetic (HN) and Post-Herpetic (PHN) Neuralgia constitute herpes zoster pain, presenting as burning spontaneous pain, allodynia and hyperalgesia. Although the literature indicates inflammatory and neuropathic processes as possible causes for HN and PHN, the mechanisms described are still innacurate and animal models do not completely describe central and peripheral sensitization in nervo…
Diabetes Mellitus (DM) affects about 425 million people worldwide and Brazil currently occupies the fourth position. Among the various complications, diabetic patients are frequently affected by ulcers, responsible for about 60% of non-traumatic lower limb amputations, resulting in high morbidity and mortality, with significant losses in quality of life and with great socioeconomic impact…
The long-term potentiation (LTP) is one of the main mechanisms responsible for the plasticity of the nervous system, involving the strengthening and formation of lasting synapses, and an increase in the intensity of synapses. LTP also participates in brain remodeling at the level of the anterior cingulate cortex (ACC) to establish chronic pain. In this process, Protein Kinase C M zeta (PK…
Neuropathic pain is one of the most rebellious conditions to the analgesic treatment, making the search for new therapies for this type of pain extremely urgent. The protocol of the electrical stimulation of the insular cortex (ESI) standardized by our group was effective for the treatment of rats with neuropathic pain, which was also able to alter the neuronal activity of regions that ar…
The insular cortex has connections with the analgesic downward pathway of pain and is the place where a painful sensation is interpreted by its intensity, in addition to being in contact with the emotional aspect of chronic pain. Neuropathic pain resulting from peripheral nerve injury is characterized by the presence of allodynia and hyperalgesia. Treatments for this type of pain are cons…
(Only some records are available in English at this moment)
Diabetes Mellitus (DM) affects about 425 million people worldwide. These patients are often afflicted with lower extremity ulcers which account for about 60% of non-traumatic lower limb amputations. This results in high morbidity and mortality, with a significant loss in quality of life and socioeconomic impact. Conventional treatment for diabetic wounds is restricted to bandages and debr…
Neuropathic pain is one of the most rebellious conditions to the antalgic treatment, making the search for new effective therapies extremely urgent. Insular cortex is a new potential target for neuromodulation once it is closely involved in central pain integration and modulation and it is deeply affected in neuropathic pain states. We have recently demonstrated that electrical stimulatio…
| 2 / 2 | Ongoing research grants |
| 5 / 4 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 12 / 8 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 24 / 19 | All research grants and scholarships |
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