CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at Biomedicina from Universidade Bandeirante de São Paulo (2008), master's at Nuclear Engineering from Universidade de São Paulo (2011) and doctorate at Nuclear Engineering from Universidade de São Paulo (2014). , acting on the following subjects: melanoma, antioxidantes, eugenia uniflora, diagnóstico and irritação da pele. (Source: Lattes Curriculum)
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Melanoma is a highly invasive and metastatic cancer, with high rates of mortality and chemoresistance. The MAPK pathway is constitutively activated, and there are already available powerful target-specific chemotherapeutics, such as BRAF inhibitors (Vemurafenib and Dabrafenib). However, resistance to BRAF inhibitors is observed after about 7 months of treatment, primarily because of the h…
In cancer, intra-tumour phenotypic heterogeneity imposed by a dynamic microenvironment is increasingly recognized as a source of drug-resistance and a driver of metastatic spread. The in vivo microenvironment is highly complex and cancer cells will be exposed to a wide range of stresses including oxygen and nutrient limitation. The ability of cells to respond to the stresses encountered i…
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