Abstract
Acquisition of multi-user equipment for analysis and applications in medicine and life sciences since much of the research and experimental protocols were optimized for use in this equipment. (AU)
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Mauricio da Silva Baptista
CV Lattes
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ORCID
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Pharmacy and Biochemistry from the University of São Paulo (1990), Master in Biological Sciences (Biochemistry) from the University of São Paulo (1992) and Ph.D. in Analytical Chemistry - Marquette University, USA (1996). He did post-doctoral studies at UW-Madison, USA School of Pharmacy (1997) and was visiting professor at Université Joseph Fourier in 2006. He is currently full professor and head of the Department of Biochemistry at the University of São Paulo and member of the State Academy of Sciences from Sao Paulo. He serves as co-editor in chief of the journals "Journal of Photochemistry and Photobiology B: Biology" and "J. Photochem. Photobiol" (open) by Elsevier, editor of pharmaceutical sciences of the journal "Recent Patents on Anti-Infective Drug Discovery" (Bentham Science), is a member of the editorial board of Scientific Reports (Nature) and guest editor of Biophysica Reviews-IUPAB meeting. He actively participates in the Brazilian Societies of Biochemistry and Molecular Biology (SBBQ), Chemistry, and Biophysics and is currently treasurer of SBBQ. And member of the board of the American Society of Photobiology (ASP). He works on the following topics: quantitative measurements in cells, membranes and interfaces, SPR, interaction of proteins with membranes, photochemistry, photobiology, photodynamic therapy, redox processes, autophagy, regulated mechanisms of cell death. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Further danger from the sun |
| Otro peligro del Sol |
| More dangerous than the sun |
| Otro peligro del Sol |
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
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Research grants
- Multi-user equipment approved in grant EMU 19/25902-3 Odyssey DLX, AP.EMU
- Implementation Plan of the Technical Reserve for Institutional Infrastructure Financial Resources granted in 2018, AP.RT.INST
Abstract
Using the resources of the Technical Reserve for Institutional Infrastructure according to the rules specified by FAPESP. (AU)
- Redoxome - Redox Processes in Biomedicine, AP.CEPID
Abstract
The study of redox processes has high potential to elucidate integrative mechanisms, due to the ubiquity and strength of their effects. Many studies involve the role of redox mechanisms in diseases. However, the complexity of this field has increased concerning structures, structure-function relations, methods, molecular and sub-cellular pathology of redox-regulated proteins, genomics, pr…
- Uncovering the PDT mechanism of new organic/inorganic hybrid photosensitizers, AP.R SPRINT
Abstract
The use of light as a therapeutic modality has recently become an attractive mode of therapy due to the development of efficient and affordable light sources, together with its low invasiveness and low systemic toxicity. Consequently, photo-activated drugs (photosensitizers-PS), are playing key roles in the present clinical portfolio (in a modality called Photodynamic Therapy-PDT). Althou…
- Inactivation (PDI) of mosquito larvae, AV.EXT
Abstract
Globalization and climate change enhances the transmission of life-threatening diseases through mosquitoes from the genre Aedes and Anopheles. The problem is increasing steadily both in America and Europe. The usage of chemical means for the control of mosquitoes and larvae leads to increased resistance to common insecticides. Furthermore, insecticides are a source of side effects and hea…
- Pharmacochemistry and photochemistry of corannulenes and natural antioxidants, AP.R SPRINT
Abstract
The present project will contribute to the knowledge of singlet oxygen formation sensitized by non-planar aromatic hydrocarbons and to the knowledge of pathways for metabolic degradation of photodynamic therapy (PDT) sensitizers and to the metabolic degradation of natural plant pigments. Both themes are related to fundamental studies of chemical or photochemical reactivity, but at the sam…
(Only some records are available in English at this moment)
Scholarships in Brazil
- The good/bad sides of visible light, BP.PD
Abstract
Protecting human skin from exposure to the sun is a complex issue that involves ambivalent aspects of the interaction of light with tissues. Visible radiation causes redox imbalance and cell damage, although it is not yet considered a class I carcinogen, such as UVA. One of the problems that hinders the proper characterization of the effects of visible radiation is the lack of molecular k…
- Effects of solar radiation on mitochondrial activity and protoporphyrin IX synthesis, BP.DD
Abstract
The skin plays an important role in maintaining the body's homeostasis, offering an effective barrier against external agents, including solar radiation. Excessive exposure to the sun causes uncontrolled production of reactive chemical species, such as electronically excited states, free radicals and many other oxidizing species, disturbing redox signaling and homeostasis and culminating …
- Chemical product management with safety and technical support for cell cultivation, BP.TT
(Only some records are available in English at this moment)
- Investigation of the photophysical properties of porphyrins coordinated with metals and effects in photoinduced damage in cell membranes, BP.IC
Abstract
This project aims to study the photophysical properties of three types of platinated tetrapyridylporphyrins, coordinated in its porphyrin ring to three different metals: Cu(II), Zn(II) and Ni(II). Along with that, we shall provide experiments to determine the phototoxicity of these three compounds, analysing the membrane damage generated by these molecules after irradiation and comparing …
- Technical support for cell culture., BP.TT
- Technical support for cell culture., BP.TT
(Only some records are available in English at this moment)
Scholarships abroad
- Ruthenium(ii) complexes containing quinone based ligands to improve membrane damage and cause PDT response, BE.EP.PD
Abstract
The project submitted here entitled "Ruthenium(II) complexes containing quinone based ligands to improve membrane damage and cause PDT response" is part of the postdoctoral project (2019/03195-3) and is related to a collaboration Project between Professor Mauricio da Silva Baptista (Universidade de São Paulo - Brazil) and Professor Claudia Turro (The Ohio State University). The strategy i…
- Study of photosensitized radical-mediated lipid oxidation by the use of a BODIPY-a-tocopherol off/on fluorescent probe in model membranes, BE.EP.DD
Abstract
Radical-mediated oxidations are expected to play an important role on photosensitized oxidations occuring in photodynamic therapy and cutaneous photoaging. Given the role of lipid photo-oxidation in these photobiological processes, in this project we aim to study the formation of lipid peroxyl radicals in model membranes, by using of BODIPY-a-tocopherol off/on fluorescent probes. These pr…
Total / Available in English
| 3 / 3 | Ongoing research grants |
| 20 / 12 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 64 / 27 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 93 / 48 | All research grants and scholarships |
| Associated processes | |