Adriana F. Paes Leme received undergraduate degree in Dentistry (DDS) at State University of Campinas in 1999, Master of Science at University of Campinas in 2002 and Ph.D. at University of Campinas in 2005. She worked as a postdoctoral fellow at Butantan Institute and Biomolecular Research Facility, University of Virginia. Currently, she is a Principal Investigator and the Director of Mass Spectrometry Facility at Brazilian Biosciences National Laboratory (LNBio), Center for Research in Energy and Materials (CNPEM), since 2009. Dr. Paes Leme has a background in oral biology, biochemistry, proteomics and mass spectrometry. Her research focuses on the development of mass spectrometry-based proteomics on complex biological systems, primarily to improve the understanding of oral cancer biology at molecular, cellular and organism levels using both discovery and targeted strategies. Link to Mass Spectrometry Laboratory: https://lnbio.cnpem.br/facilities/mass-spectrometry/. Link to http://scholar.google.com/citations?user=vey-6EgAAAAJ&hl=e (Source: Lattes Curriculum)
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Oral squamous cell carcinoma (OSCC) is the most common type of head and neck malignant tumor. Alcohol exposure is strongly associated with OSCC carcinogenesis, modifying the microenvironment. Our hypothesis is that alcohol exposure changes antigen processing and presentation through keratinocytes and fibroblast-derived extracellular vesicles (EV) that promote tolerance and suppress the im…
Although there have been several advances in research and improvements in oral squamous cell carcinoma (OSCC) treatments, the survival rate at 5 years from diagnosis is still about 50%. The excessive consumption of alcohol is prominent risk factor in oral cancer. The cancer progression does not depend solely on cancer cell-autonomous defects, but also on the dynamic crosstalk among the co…
Visite Plan: 1. Seminar at LNBio on the 'Role of ectodomain shedding of signaling proteins on extracellular vesicle for the tumor-supporting communication between cancer and supporter cells - options for targeted cancer therapy'. 2. Laboratory work: Introduction and help in establishing a test system to determine the metalloproteinase activity on the surface of extracellular vesicles. The…
(Only some records are available in English at this moment)
Treatment of patients with oral squamous cell carcinoma (OSCC) represents a clinical challenge. Despite advances in therapeutic modalities, OSCC recurrence rates vary between 18% to 76% in patients that received the standard treatment of surgery, radiotherapy and/or chemotherapy. Moreover, OSCC patients demonstrates a low response to other therapeutic modalities, such as EGFR monotherapy …
This project has the objective to combine omics strategies to answer our reductionist hypotheses that (1) alcohol alters resting fibroblast and/or keratinocyte-derived EVs, (2) alcohol-altered EVs can modify the cell microenvironment phenotype, (3) the selected EV proteins are candidates as therapeutic targets. The post-doctorate (PD) will be responsible in the first hypothesis to evaluat…
(Only some records are available in English at this moment)
Oral Cancer accounts for 2.0% of all new Cancer cases and approximately 90% are Squamous Cell Carcinomas (SCC). The main risk factors for oral SCC are excessive tobacco and alcohol consumption, leading to a complex carcinogenic process. Oral SCC often evolves from potentially malignant disorders such as Oral Leukoplakia (OL), which is one of the most prevalent, and Proliferative Verrucous…
This project has the objective to combine omics strategies to answer our reductionist hypotheses that (1) alcohol alters resting fibroblast and/or keratinocyte-derived EVs; (2) alcohol-altered EVs can modify the cell microenvironment phenotype; (3) the selected EV proteins are candidates as therapeutic targets. The Post-Doctorate (PD) will be responsible in the first hypothesis to evaluat…
Cystatin B (CSTB) has emerged as an important mediator of carcinogenesis, as well as angiogenesis and tumor growth. In our previous study (Carnielli et al., 2018), we have demonstrated that low level of CSTB, in front of tumor region, is correlated to poor prognostic in patients with oral cancer squamous cells carcinoma (OSCC). Additionally, we found out CSTB levels are correlated to loca…
(Only some records are available in English at this moment)
The diagnosis of oral squamous cell carcinoma (OSCC) is commonly realized in advanced stages, which leads to invasive therapies, decreased survival rates, and a worse prognosis. Even in São Paulo, the most developed state of Brazil, more than 70% of patients are diagnosed with stages III/IV disease. OSCC onset may be preceded by a group of oral disorders, such as oral leukoplakia (OL) and…
One of the major challenges of oral cancer is the late diagnosis, which affects the therapeutic treatment with a negative influence on prognosis and, consequently, survival rate. The standard treatments include surgery, radiotherapy, and/or chemotherapy. However, these treatments often result in numerous adverse side effects and multi-drug resistance, which leads to a poor therapeutic res…
Extracellular vesicles (EVs) are key players in cancer progression and metastasis by inducing changes in the tumour-microenvironment, extracellular matrix and pre-metastatic niches towards favourable sites for tumour growth and spread. Lymph node metastasis is the main prognostic factor in patients with oral squamous cell carcinoma (OSCC) and can decrease the 5-year survival rates to less…
Oral squamous cell carcinoma (OSCC) is the most common type of head and neck malignant tumor and the eighth leading cause of cancer worldwide, with high prevalence and morbidity. Thus, identification of molecular signatures that may assist in the prognostication of patients with OSCC is desperately needed. Interestingly, glycoprofiling of a gingival carcinoma cell line have already indica…
Oral squamous cell carcinoma (OSCC) is the most incident malignant tumor in head and neck cancer, with 300,000 new cases and 145,000 deaths around the world per year, with 50% survival rate of advanced cases after five years of diagnosis. The molecular mechanisms involved in this tumor establishment are poorly characterized, and no molecular markers are currently available in clinical pra…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 15 / 10 | Completed research grants |
| 8 / 8 | Ongoing scholarships in Brazil |
| 31 / 26 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 10 / 9 | Completed scholarships abroad |
| 68 / 57 | All research grants and scholarships |
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CV Lattes
ORCID