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METHOD FOR OBTAINING LIPID NANOSTRUCTURES, THUS OBTAINED LIPID NANOSTRUCTURES AND USE THEREOF
Patrícia Bento da Silva; Regina Célia Galvão Frem; Adelino Vieira de Godoy Netto; Antonio Eduardo Mauro; Ana Maria da Costa Ferreira; Fernando Rogério Pavan; Clarice Queico Fujimura Leite; Marlus Chorilli
The present invention relates to a method for obtaining lipid nanostructures comprising copper-isoniazid compounds. In addition, the present invention relates to the lipid nanostructures comprising copper-isoniazid compounds obtained by the present method, and to the use thereof to prepare medicinal drugs against mycobacteria in general. In a preferred embodiment, the invention relates to the use of the lipid nanostructures comprising copper-isoniazid compounds obtained by the present method, preferably MEB-I3 and MEB-I1, to prepare medicinal drugs for the treatment of active and latent tuberculosis, respectively.